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Tardive dyskinesia Market is expected to reach USD 8.2 billion by 2034

09-19-2025 11:26 AM CET | Health & Medicine

Press release from: Exactitude Consultancy

Tardive dyskinesia

Tardive dyskinesia

Tardive dyskinesia (TD) is a neurological movement disorder caused primarily by long-term use of dopamine receptor-blocking agents, such as antipsychotics and certain antiemetics. It is characterized by involuntary, repetitive movements of the face, tongue, and limbs, often irreversible and severely affecting quality of life. With the rising prevalence of psychiatric conditions such as schizophrenia, bipolar disorder, and major depressive disorder-and the increased use of antipsychotic medications-TD has emerged as a growing public health concern.

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For decades, there were no effective treatments for TD, leaving patients reliant on discontinuation or modification of antipsychotics, often at the expense of psychiatric stability. However, recent approvals of vesicular monoamine transporter 2 (VMAT2) inhibitors, such as valbenazine (Ingrezza) and deutetrabenazine (Austedo), have significantly advanced the therapeutic landscape. Increasing awareness, regulatory support, and investment in neurological research are expected to fuel steady market growth over the next decade.

Market Overview
• Market Size 2024: USD 3.6 billion (estimated)
• Forecasted Market Size 2034: USD 8.2 billion
• CAGR (2024-2034): 8.5%

Key Highlights
• Rising global prevalence of schizophrenia, bipolar disorder, and TD-linked antipsychotic usage.
• Strong uptake of VMAT2 inhibitors (Ingrezza, Austedo).
• Expanding R&D in novel formulations, combination therapies, and long-acting injectables.
• Growing advocacy and awareness initiatives for TD diagnosis and treatment access.

Segmentation Analysis
By Product
• VMAT2 inhibitors
o Valbenazine (Ingrezza - Neurocrine Biosciences)
o Deutetrabenazine (Austedo - Teva Pharmaceutical)
• Adjunctive therapies
o Anticholinergics
o Benzodiazepines
o Botulinum toxin (off-label use)
• Pipeline drugs
o Novel VMAT2 inhibitors
o Neuroprotective and gene-modulating therapies

By Platform
• Hospital pharmacies
• Retail pharmacies
• Online pharmacies
• Specialty clinics

By Technology
• Oral pharmacological therapies
• Long-acting injectables (pipeline stage)
• Digital health and monitoring tools for side effect management

By End Use
• Hospitals and psychiatric centers
• Neurology and movement disorder clinics
• Homecare and long-term care facilities

By Application
• Schizophrenia-associated TD
• Bipolar disorder-associated TD
• Depression-related TD (from adjunctive antipsychotic therapy)
• Other psychiatric/neurological conditions

Summary:
VMAT2 inhibitors dominate today's market, but the pipeline is expanding with new oral and injectable formulations that promise better compliance and outcomes.

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Regional Analysis
North America
• Largest market share in 2024, driven by high prevalence of schizophrenia, strong adoption of Ingrezza and Austedo, and robust reimbursement frameworks.
• Active awareness campaigns by psychiatric associations.
Europe
• Significant adoption in Germany, France, and the UK, supported by EU rare disease and neurological drug policies.
• Growing inclusion of TD in clinical psychiatric guidelines.
Asia-Pacific
• Fastest-growing region (CAGR ~9.7%), driven by rising psychiatric medication use in China, Japan, and India.
• Increasing healthcare investment and improving access to novel therapies.
Middle East & Africa
• Limited market penetration due to diagnostic challenges and affordability issues.
• Slowly growing awareness programs for movement disorders.
Latin America
• Brazil and Mexico lead adoption, supported by improving access to VMAT2 inhibitors.
• Expanding role of generics and regional partnerships.
Summary:
North America leads in adoption and access, while Asia-Pacific is set to be the fastest-growing region, supported by a large psychiatric patient base and expanding healthcare infrastructure.

Market Dynamics
Key Growth Drivers
• Rising prevalence of psychiatric disorders requiring long-term antipsychotic use.
• Expanding adoption of VMAT2 inhibitors as the standard of care.
• Increasing awareness and advocacy efforts to improve TD diagnosis rates.
• Supportive regulatory frameworks and orphan drug incentives.

Key Challenges
• High cost of VMAT2 inhibitors, limiting accessibility in low-income regions.
• Underdiagnosis and misdiagnosis of TD in psychiatric populations.
• Safety concerns regarding long-term VMAT2 inhibitor use.
• Small but growing competition from off-label therapies.

Latest Trends
• Development of next-generation VMAT2 inhibitors with improved tolerability.
• Research into long-acting injectables to enhance compliance.
• Use of AI-based tools for early detection and monitoring of movement disorders.
• Growing inclusion of TD in real-world evidence registries to track outcomes.

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Competitor Analysis
Major Players
• Neurocrine Biosciences, Inc. (Ingrezza - market leader)
• Teva Pharmaceutical Industries Ltd. (Austedo)
• Sunovion Pharmaceuticals Inc. (CNS and movement disorder portfolio)
• Lundbeck A/S (neurology pipeline, VMAT2 collaborations)
• Biogen Inc. (neurological R&D programs)
• Otsuka Holdings Co., Ltd. (antipsychotics portfolio, TD awareness initiatives)
• Pfizer Inc. (psychiatric pipeline)
• Johnson & Johnson (psychiatric drugs and partnerships in TD research)
• AbbVie Inc. (neurological disorder pipeline)
• Smaller biotech innovators exploring neuroprotective and genetic approaches.

Summary:
The TD market is consolidated around Neurocrine Biosciences and Teva, but competition is expanding as Lundbeck, Biogen, and Otsuka push new CNS portfolios.

Conclusion
The tardive dyskinesia market is projected to grow from USD 3.6 billion in 2024 to USD 8.2 billion by 2034, at a CAGR of 8.5%. Innovation in VMAT2 inhibitors, rising awareness, and global expansion of psychiatric care will fuel growth.

Key Takeaways:
• North America dominates today's market, but Asia-Pacific will grow fastest.
• VMAT2 inhibitors (Ingrezza, Austedo) are the cornerstones of treatment, with new formulations in development.
• Challenges include underdiagnosis, high therapy cost, and safety monitoring.
• Competitive strategies focus on pipeline expansion, digital tools for movement disorder monitoring, and regional partnerships.

Looking ahead, the TD market will shift from limited options to a multi-faceted ecosystem, combining pharmacological advances, digital monitoring, and patient advocacy, significantly improving outcomes and quality of life for affected individuals.

This report is also available in the following languages : Japanese (遅発性ジスキネジア市場), Korean (타디브 디스키네시아 시장), Chinese (迟发性运动障碍市场), French (Marché de la dyskinésie tardive), German (Markt für Spätdyskinesien), and Italian (Mercato della discinesia tardiva), etc.

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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
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