United States Organ-On-Chip Market Research | Latest Developments & Forecast Trends

Organ-on-a-chip Market size reached US$ 165.98 million in 2024 and is expected to reach US$ 1,956.28 million by 2032, growing with a CAGR of 36.12% during the forecast period 2025-2032.

According to DataM Intelligence has released its latest research report on "Organ-On-Chip Market Size 2025," offering in-depth insights into key growth factors such as regional performance, market segmentation, CAGR trends, revenue analysis of leading players, and major drivers shaping the industry. This report provides a clear and forward-looking perspective on market size (both value and volume), emerging opportunities, and current development status helping businesses identify growth potential and make informed strategic decisions

In March 2024, the UK awarded a £7 million grant to Queen Mary University to establish an EPSRC Centre for Doctoral Training, highlighting strong institutional support. Such initiatives make Organ-on-a-chips more precise and sustainable, reducing biohazard waste while aligning drug development with environmentally responsible practices.

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Organ-on-a-Chip Market Trend

A major trend is the shift from conventional preclinical models, as over 80% of drug candidates fail in trials-30% from toxicity and 60% from inefficacy. Organ-on-a-chips provide more accurate human outcome predictions, reducing late-stage failures. This shift is reinforced by the FDA Modernization Act 2.0 (December 2022), which allows non-animal data for drug applications.

For example, in June 2023, Emulate Inc. introduced the Chip-A1 Accessible Chip, a membrane-free blood-brain barrier model with advanced imaging for testing neuroinflammatory therapies. However, broader adoption in clinical workflows remains limited until these technical challenges are addressed at scale.

Organ-on-a-chip systems are gaining traction in early drug discovery as realistic alternatives to animal testing, especially for human-specific metabolism and toxicity studies. The FDA Modernization Act 2.0 (December 2022) has further accelerated their adoption.

Top Key Players:

Emulate Inc., Mimetas B.V., Insphero, Organovo Holdings, CN Bio Innovations Ltd, BiomimX S.r.l., AxoSim, Inc., Hesperos Inc., TissUse GmbH and Nortis Inc.

Key Industry Developments

In April 2024, CN Bio raised US$21 million in Series B funding to expand organ-on-a-chip development, fueled by rising demand and FDA Modernization Act 2.0.

In March 2024, MIMETAS joined the Centre for Animal-Free Biomedical Translation (CPBT), backed by US$134.78 million from the Dutch National Growth Fund.

Earlier, in October 2023, AxoSim acquired Stemonix's microBrain technology, enhancing its neurological drug discovery platforms alongside NerveSim and BrainSim.

Growth Projection:

The Global Organ-On-Chip Market is set to witness significant growth between 2025 and 2032. While 2024 reflects steady progress, the increasing adoption of innovative strategies by leading players is expected to accelerate growth across the projected horizon. This creates a strong landscape of opportunities for businesses looking to expand, invest, and stay competitive in a rapidly evolving market.

Research Process:

The Organ-On-Chip Market research report by DataM Intelligence leverages both primary and secondary data sources to deliver deep insights. It explores a wide range of factors shaping the industry from government regulations, market conditions, and competitive dynamics to historical trends, technological advancements, upcoming innovations, and potential challenges. This comprehensive analysis highlights growth prospects while addressing barriers, helping businesses navigate volatility and seize new opportunities

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Market Segmentation:

By Model: (Liver-On-Chip Model, Lung-On-Chip Model, Heart-On-Chip Model, Kidney-On-Chip Model, Tumor Models, Custom & Multi-Organ-On-Chip Models, Other)

By Application: (Drug Discovery, Physiological Model Development, Toxicology Research)

By End User: (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Others)

Top Growth Regions:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

Benefits of the Report:

Chapter 1: Introduces the report with an overview of coverage summarizing key market segments by region, product type, and application. It offers a clear snapshot of market size, segment-wise growth potential, and both short- and long-term industry outlook.

Chapter 2: Brings forward the most valuable market insights and reveals the game-changing emerging trends shaping the industry's future.

Chapter 3: Provides a detailed analysis of the competitive landscape among Organ-On-Chip covering revenue shares, strategic initiatives, and the latest mergers & acquisitions.

Chapter 4: Delivers comprehensive profiles of top players, including revenue, profit margins, product lines, and company milestones.

Chapters 5 & 6: Break down revenue performance across regions and countries, offering a precise view of market sizes, opportunities, and development prospects worldwide.

Chapter 7: Examines segmentation by type, revealing the size and potential of each category guiding businesses toward untapped, high-impact areas.

Chapter 8: Focuses on applications, evaluating how different downstream markets are growing and identifying promising sectors for expansion.

Chapter 9: Maps the entire industry supply chain, detailing both upstream and downstream activities for a holistic understanding.

Chapter 10: Concludes with key findings and the most critical takeaways giving stakeholders a clear direction for future strategies.

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FAQ's

Q1: How fast is the Organ-On-Chip Market growing?

A: The Market is on a robust growth path, expected to expand at a CAGR of 36.12% between 2025 and 2032.

Q2: Which Regions dominate the Organ-On-Chip Market?

A: Currently, R&D investments and regulatory support are driving growth in North America's organ-on-a-chip market.

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