COPD Market Anticipated to Expand Rapidly During 2024-2034, Says DelveInsight

DelveInsight's "Chronic Obstructive Pulmonary Disease Market Insights, Epidemiology, and Market Forecast-2034′′ report offers an in-depth understanding of the Chronic Obstructive Pulmonary Disease, historical and forecasted epidemiology as well as the Chronic Obstructive Pulmonary Disease market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

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Some of the key facts of the Chronic Obstructive Pulmonary Disease Market Report:
• The Chronic Obstructive Pulmonary Disease market size was valued approximately USD 11.5 billion in 2024 and is anticipated to grow with a significant CAGR during the study period (2020-2034).
• In July 2025, Upstream Bio has initiated dosing in the Phase II randomized trial of verekitug, an antibody antagonist of the thymic stromal lymphopoietin (TSLP) receptor, for patients with chronic obstructive pulmonary disease (COPD). The VENTURE study, a double-blind, placebo-controlled trial, will assess the safety and efficacy of the therapy in about 670 adults with moderate-to-severe COPD. Participants will receive either 100 mg of verekitug every 12 weeks, 400 mg every 24 weeks, or placebo, over treatment durations of 60 to 108 weeks.
• In June 2025, Sanofi and Regeneron announced that the Phase III AERIFY-1 trial evaluating the fully human monoclonal antibody itepekimab in former smokers with inadequately controlled COPD met its primary objective. Former smokers were defined as individuals who had abstained from smoking for at least six months. The trial, involving 1,127 participants, achieved its primary endpoint by demonstrating a 27% reduction in moderate or severe acute exacerbations compared to placebo at week 52.
• In May 2025, The AERIFY-1 Phase 3 trial testing itepekimab in former smokers with inadequately controlled COPD achieved its primary goal, showing a 27% reduction in moderate or severe acute exacerbations versus placebo at week 52, marking a clinically meaningful outcome. In contrast, the AERIFY-2 Phase 3 study did not reach the same primary endpoint, though early benefits were observed during the course of the trial, according to a press release from Sanofi and Regeneron.
• In April 2025, Sanofi and Regeneron announced that their Phase III AERIFY-1 trial evaluating the fully human monoclonal antibody itepekimab in former smokers with inadequately controlled chronic obstructive pulmonary disease (COPD) has met its primary objective. Former smokers were defined as individuals who had not smoked for at least six months. The trial, which enrolled 1,127 participants, successfully met its primary endpoint by demonstrating a 27% reduction in moderate or severe acute exacerbations compared to placebo at week 52.
• In April 2025, Connect Biopharma Holdings Limited (Nasdaq: CNTB), a clinical-stage biopharmaceutical company dedicated to advancing treatments for asthma and chronic obstructive pulmonary disease (COPD), has received encouraging feedback from its Type C meeting with the U.S. Food and Drug Administration (FDA), specifically the Division of Pulmonology, Allergy, and Critical Care within the Office of Immunology and Inflammation.
• In March 2025, SMSbiotech has reached a key milestone in advancing its regenerative medicine platform, receiving approval to initiate a Phase I clinical trial in Australia (registration number: ANZCTR12624001140549p). The trial will assess the safety and tolerability of the company's novel Small Mobile stem (SMS) cell therapy for the treatment of Chronic Obstructive Pulmonary Disease (COPD). This marks a significant step in SMSbiotech's mission to tackle this debilitating lung condition. Notably, the Phase I study in Australia will be the first human trial of this specific cell-based therapy.
• In March 2025, Japan's Ministry of Health, Labour and Welfare has approved the marketing and manufacturing of Dupixent (dupilumab) for the treatment of chronic obstructive pulmonary disease (COPD) in adults who do not achieve sufficient control with current treatment options.
• In January 2025, Aer Therapeutics ("Aer"), a biopharmaceutical company focused on developing innovative inhaled therapies for mucus-related lung diseases, announced that the first patient has been dosed in its Phase 2a proof-of-concept (POC) clinical trial of fexlamose (previously known as AER-01) for Chronic Obstructive Pulmonary Disease (COPD).
• In September 2024, GSK's asthma drug Nucala (mepolizumab) achieved its primary endpoint in a Phase III trial for treating patients with chronic obstructive pulmonary disease (COPD). Results from the MATINEE study revealed that adding Nucala to inhaled maintenance therapy significantly lowered the annualized rate of moderate or severe exacerbations compared to placebo.
• In April 2024, Amgen (NASDAQ: AMGN) shared an update on the Phase 2a COURSE trial results for TEZSPIRE® (tezepelumab-ekko) in chronic obstructive pulmonary disease (COPD), which will be presented at the American Thoracic Society (ATS) 2024 International Conference. The trial, which investigated tezepelumab in patients with moderate to very severe COPD across various eosinophil levels and inflammatory drivers, showed promising results. The study did not exclude patients based on baseline eosinophil count (BEC) and enrolled a diverse group. Tezepelumab reduced the annualized rate of moderate or severe COPD exacerbations by 17% compared to placebo, though the result did not reach statistical significance.
• In January 2024, Theravance Biopharma, Inc. (NASDAQ: TBPH) has released findings from the Phase 4 PIFR-2 trial of YUPELRI® (revefenacin) inhalation solution, the sole once-daily, nebulized long-acting muscarinic antagonist (LAMA) authorized in the U.S. for COPD maintenance therapy. The PIFR-2 study aimed to illustrate superior lung function enhancement with YUPELRI administered via standard jet nebulizer versus Spiriva® (tiotropium) delivered through a dry powder inhaler (Spiriva® HandiHaler®) in severe to very severe COPD patients with suboptimal peak inspiratory flow rate (PIFR).
• In the 7MM, the United States held the largest COPD market, valued at approximately USD 9.3 billion in 2024.
• In 2024, the total diagnosed prevalent cases of COPD across the 7MM were approximately 31 million.
• In 2024, chronic bronchitis represented the largest portion of COPD cases in the EU4 and the UK, totaling approximately 6.42 million cases.
• In Japan, a notable disparity exists between the estimated COPD population and those receiving treatment, reflecting widespread underdiagnosis and a high unmet need for improved early detection and management. In 2024, the highest number of cases was observed in the 65-74-year age group, totaling approximately 283,000.
• Key Chronic Obstructive Pulmonary Disease Companies: Genentech, Inc., GlaxoSmithKline, Verona Pharma plc, Regeneron Pharmaceuticals, Sanofi, MedImmune LLC, EpiEndo Pharmaceuticals, Tetherx Pharmaceuticals, AstraZeneca, Chiesi Farmaceutici S.p.A., Synairgen Research Ltd., Mereo Biopharma, Organicell Regenerative Medicine, Pulmotect, Inc., Inmunotek S.L., PULMATRiX, GLENMARK PHARMACEUTICALS LTD, Dimerix Limited, ProterixBio, and others
• Key Chronic Obstructive Pulmonary Disease Therapies: Astegolimab (MSTT1041A, AMG 282, RG6149), SB240563 (Mepolizumab)/NUCALA, Ensifentrine (RPL554), Itepekimab/SAR440340/REGN3500, Dupilumab/SAR231893 (Dupixent), Tozorakimab (MEDI3506), FASENRA (Benralizumab), Tezspire (Tezepelumab), EP395, SelK2, Mitiperstat (AZD4831), CHF6001/Tanimilast, SNG001 (IFN-β), Acumapimod (BCT-197), Zofin, PUL-042, MV130, GSK3923868, PUR1800, GRC 39815, DMX-700, and others.
• The Chronic Obstructive Pulmonary Disease epidemiology based on gender analyzed that the majority of cases of COPD are of female as compared to male, in the US
• The Chronic Obstructive Pulmonary Disease market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Chronic Obstructive Pulmonary Disease pipeline products will significantly revolutionize the Chronic Obstructive Pulmonary Disease market dynamics.

Chronic Obstructive Pulmonary Disease Overview
Chronic obstructive pulmonary disease (COPD) is a widespread, treatable, and avoidable illness marked by ongoing respiratory symptoms and restricted airflow because of abnormalities in the airways or alveoli, which are typically brought on by prolonged exposure to harmful particles or gases.

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Chronic Obstructive Pulmonary Disease Epidemiology
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Chronic Obstructive Pulmonary Disease Epidemiology Segmentation:
The Chronic Obstructive Pulmonary Disease market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:
• Total Prevalence of Chronic Obstructive Pulmonary Disease
• Prevalent Cases of Chronic Obstructive Pulmonary Disease by severity
• Gender-specific Prevalence of Chronic Obstructive Pulmonary Disease
• Diagnosed Cases of Episodic and Chronic Chronic Obstructive Pulmonary Disease

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Chronic Obstructive Pulmonary Disease Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Chronic Obstructive Pulmonary Disease market or expected to get launched during the study period. The analysis covers Chronic Obstructive Pulmonary Disease market uptake by drugs, patient uptake by therapies, and sales of each drug.
Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the Chronic Obstructive Pulmonary Disease Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Chronic Obstructive Pulmonary Disease Therapies and Key Companies
• Itepekimab/SAR440340/REGN3500: Regeneron Pharmaceuticals/Sanofi
• Dupilumab/SAR231893 (Dupixent): Regeneron Pharmaceuticals/Sanofi
• Tozorakimab (MEDI3506): AstraZeneca/MedImmune LLC
• FASENRA (Benralizumab): AstraZeneca
• Tezspire (Tezepelumab): AstraZeneca
• Astegolimab (MSTT1041A, AMG 282, RG6149): Genentech, Inc.
• SB240563 (Mepolizumab)/NUCALA: GlaxoSmithKline
• Ensifentrine (RPL554): Verona Pharma plc
• EP395: EpiEndo Pharmaceuticals
• SelK2: Tetherx Pharmaceuticals
• Mitiperstat (AZD4831): AstraZeneca
• CHF6001/Tanimilast: Chiesi Farmaceutici S.p.A.
• SNG001 (IFN-β): Synairgen Research Ltd.
• Acumapimod (BCT-197): Mereo Biopharma
• Zofin: Organicell Regenerative Medicine
• PUL-042: Pulmotect, Inc.
• MV130: Inmunotek S.L.
• GSK3923868: GlaxoSmithKline
• PUR1800: PULMATRiX
• GRC 39815: GLENMARK PHARMACEUTICALS LTD
• DMX-700: Dimerix Limited

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Chronic Obstructive Pulmonary Disease Market Strengths
• The prevalence of COPD is increasing dramatically in recent years due to the higher smoking prevalence and aging populations in many countries.

Chronic Obstructive Pulmonary Disease Market Opportunities
• There is a growing demand for fixed-dose combinations as combination therapy can enhance and prolong the effects of monocomponent.

Scope of the Chronic Obstructive Pulmonary Disease Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
• Key Chronic Obstructive Pulmonary Disease Companies: Genentech, Inc., GlaxoSmithKline, Verona Pharma plc, Regeneron Pharmaceuticals, Sanofi, MedImmune LLC, EpiEndo Pharmaceuticals, Tetherx Pharmaceuticals, AstraZeneca, Chiesi Farmaceutici S.p.A., Synairgen Research Ltd., Mereo Biopharma, Organicell Regenerative Medicine, Pulmotect, Inc., Inmunotek S.L., PULMATRiX, GLENMARK PHARMACEUTICALS LTD, Dimerix Limited, ProterixBio, and others
• Key Chronic Obstructive Pulmonary Disease Therapies: Astegolimab (MSTT1041A, AMG 282, RG6149), SB240563 (Mepolizumab)/NUCALA, Ensifentrine (RPL554), Itepekimab/SAR440340/REGN3500, Dupilumab/SAR231893 (Dupixent), Tozorakimab (MEDI3506), FASENRA (Benralizumab), Tezspire (Tezepelumab), EP395, SelK2, Mitiperstat (AZD4831), CHF6001/Tanimilast, SNG001 (IFN-β), Acumapimod (BCT-197), Zofin, PUL-042, MV130, GSK3923868, PUR1800, GRC 39815, DMX-700, and others
• Chronic Obstructive Pulmonary Disease Therapeutic Assessment: Chronic Obstructive Pulmonary Disease current marketed and Chronic Obstructive Pulmonary Disease emerging therapies
• Chronic Obstructive Pulmonary Disease Market Dynamics: Chronic Obstructive Pulmonary Disease market drivers and Chronic Obstructive Pulmonary Disease market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Chronic Obstructive Pulmonary Disease Unmet Needs, KOL's views, Analyst's views, Chronic Obstructive Pulmonary Disease Market Access and Reimbursement

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