Gene Silencing Market Landscape 2025: Forecast Data and Growth Strategy Insights

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What Is the Expected CAGR for the Gene Silencing Market Through 2025?
The market size for gene silencing has seen a swift expansion in the past few years. It is projected to rise from $5.97 billion in 2024 to $6.69 billion in 2025, boasting a compound annual growth rate (CAGR) of 12.0%. The notable growth during the historic period can be credited to the surge in genetic therapy research, preliminary breakthroughs in RNA interference, the escalating occurrence of genetic disorders, increased funding in biotechnology, and expanding biopharmaceutical manufacturing abilities.

What's the Projected Size of the Global Gene Silencing Market by 2029?
The market size of gene silencing is anticipated to experience fast expansion in the foroming years, with projections to reach $10.74 billion by 2029, progressing at a compound annual growth rate (CAGR) of 12.6%. The advancement in the prediction period is driven by factors such as its increasing utilisation in the treatment of uncommon diseases, advancement in delivery systems technology, growing need for tailor-made medicine, supportive policies from the government, and increased collaborations amongst pharmaceutical and biotech firms. The forecast period is also expected to see significant trends like the creation of targeted gene therapies, the ascendency of CRISPR-based silencing strategies, heightened focus on rare and orphan diseases, the advent of nanoparticle delivery systems, and the integration into agricultural gene silencing applications.

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Top Growth Drivers in the Gene Silencing Industry: What's Accelerating the Market?
The surge in genetic disorders is anticipated to fuel the expansion of the gene silencing market. Genetic disorders, which are health issues resulting from anomalies in a person's DNA, are being detected with increasing regularity due to technological advancements in medical diagnostics, improved awareness, and wider availability of genetic testing. The geriatric parent population contributes to the growth of genetic disorders, escalating the risk of gene mutations transmitted to the next generation. Gene silencing, which involves the targeted deactivation of diseased or malfunctioning genes, presents a promising method for treating genetic disorders. As per Down Syndrome UK, a UK-based non-profit organization, as of August 2023, about 40,000 individuals in the UK were affected by Down syndrome, equivalent to approximately 1 in 800 newborns suffering from this condition. Hence, the escalating incidence of genetic disorders propels the advancement of the gene silencing market.

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Which Emerging Trends Are Transforming the Gene Silencing Market in 2025?
Leading firms within the gene silencing arena are prioritizing the creation of groundbreaking technologies like small interfering RNA (siRNA) to bolster accuracy and effectiveness in gene therapy. The siRNA is an RNA molecule variety vital to the RNA interference (RNAi) process. It works by attaching to a specific messenger RNA (mRNA) and encouraging its breakdown, effectively halting the creation of proteins that cause diseases. An example of this innovative approach was shown by Judo Bio Inc., a biotech firm based in the US, when they unveiled a next-generation drug that uses small interfering RNA (siRNA) to mute genes in October 2024. This product possesses unique attributes such as proprietary delivery mechanisms, including lipid nanoparticles or bond ligands, guaranteeing efficient absorption by particular cells or tissues. Also, AI-backed platforms that expedite the discovery of feasible gene targets.

What Are the Main Segments in the Gene Silencing Market?
The gene silencing market covered in this report is segmented -

1) By Type: Transcriptional, Post-Transcriptional, Meiotic
2) By Gene Silencing: RNA Interference (RNAi), Antisense Oligonucleotides (ASOs), Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR) Or Cas9 -Based Gene Silencing, Other Gene Silencings
3) By Application: Neurology, Oncology, Infectious Diseases, Metabolic Diseases, Therapeutics Manufacturing, Other Applications
4) By End-Users: Pharmaceutical And Biotechnology Companies, Research Institutes and Academic Centers, Hospitals, Clinics, Other End-Users

Subsegments:
1) By Transcriptional: DNA Methylation, Histone Modification
2) By Post-Transcriptional: RNA Interference (RNAi), Antisense Oligonucleotides, MicroRNA (miRNA) Mediated Silencing
3) By Meiotic: Meiotic Gene Conversion, Transposable Element Silencing

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Which Top Companies are Driving Growth in the Gene Silencing Market?
Major companies operating in the gene silencing market are Roche Holding AG, Merck & Co. Inc., AstraZeneca plc, Novartis International AG, Thermo Fisher Scientific Inc., Danaher Corporation, Agilent Technologies Inc., Illumina Inc., Bio-Rad Laboratories Inc., Bio-Techne Corporation, Alnylam Pharmaceuticals Inc., GenScript Biotech Corporation, Oxford BioMedica plc, Ionis Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., Dicerna Pharmaceuticals Inc., New England Biolabs Inc., Quark Pharmaceuticals Inc., Sirion Biotech GmbH, Benitec Biopharma Limited, GeneCopoeia Inc., Revvity Inc.

Which Regions Will Dominate the Gene Silencing Market Through 2029?
North America was the largest region in the gene silencing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the gene silencing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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