PARP Inhibitor Biomarkers Market to Reach US$ 1.83 Bn by 2032, Reports Persistence Market Research

The global PARP inhibitor biomarkers market is witnessing significant growth, with a projected compound annual growth rate (CAGR) of 8.5% from 2025 to 2032. By the end of the forecast period, the market is expected to reach a value of US$ 1,833.4 million, up from US$ 1,035.3 million in 2025. This growth is fueled by the rising prevalence of cancers, advancements in personalized medicine, and the increasing demand for precision oncology treatments. As the market continues to evolve, PARP inhibitors are becoming integral to targeted cancer therapies, providing hope for patients with genetic mutations like BRCA1 and BRCA2.

PARP inhibitors, a class of targeted therapies, are primarily used to treat cancers with DNA repair deficiencies, such as breast and ovarian cancers, by inhibiting poly (ADP-ribose) polymerase (PARP), a protein involved in DNA repair. These inhibitors are effective in patients with mutations in the BRCA1 and BRCA2 genes, which are crucial for the development of personalized treatment regimens. Alongside these inhibitors, the role of biomarkers is critical in identifying which patients are most likely to benefit from these therapies, further driving the market for biomarker testing.

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Overview of the Market

The PARP inhibitor biomarkers market is thriving due to the increasing demand for personalized cancer therapies. These therapies are designed to target the molecular makeup of individual patients, allowing for more effective treatments. In particular, cancers that show deficiencies in DNA repair mechanisms, such as those caused by BRCA mutations, are showing strong responses to PARP inhibitors. According to Persistence Market Research, the market is expected to continue to grow at a steady pace, with North America, Europe, and Asia Pacific being key contributors to the global market share.

The key growth drivers behind this market include rising cancer incidences, a better understanding of genetic mutations, and increased efforts in clinical trials to expand the indications of PARP inhibitors. As more genetic markers are discovered, additional cancers are being targeted with PARP inhibitors, further driving market growth. North America remains the leading geographical region due to the high incidence rates of cancers linked to BRCA mutations, such as breast and ovarian cancers. The region's advanced healthcare infrastructure and the adoption of precision oncology solutions play a pivotal role in its dominant market position.

Key Highlights from the Report

• The global PARP inhibitor biomarkers market is expected to grow at a CAGR of 8.5% from 2025 to 2032.
• The BRCA1 and 2 testing kits segment will hold a significant market share of 43.4% in 2025.
• Breast cancer is expected to generate 46.2% of the market share in 2025, driven by clinical evidence supporting PARP inhibitors for BRCA-mutated breast cancer.
• North America is set to dominate the market with a 42.7% share in 2025 due to high rates of BRCA-related cancers.
• Over 300 clinical trials are currently underway to explore the potential of PARP inhibitors in cancers beyond breast and ovarian cancers.
• Increased investment in research and the growing need for personalized cancer treatments are major market drivers.

Market Segmentation
Product Type-Based Segmentation

The PARP inhibitor biomarkers market is segmented based on product types, with BRCA1 and BRCA2 testing kits expected to capture the largest market share. These kits play a crucial role in identifying individuals at hereditary risk of cancer, particularly breast and ovarian cancers. The efficiency and specificity of these kits make them a preferred option for clinicians, contributing significantly to market growth. In addition to BRCA testing, other biomarker assays such as Homologous Recombination Deficiency (HRD) and Homologous Recombination Repair (HRR) testing are gaining traction. These tests are critical for identifying patients eligible for PARP inhibitors, especially those with other genetic mutations beyond BRCA.

However, the cost of HRD and HRR tests remains a barrier to their widespread adoption. In comparison, BRCA testing kits offer a more affordable alternative, despite their limited scope. As the technology behind these assays improves, it is expected that prices will decrease, leading to broader use of these advanced biomarker tests.

Application-Based Segmentation

In terms of applications, breast cancer is expected to hold the largest market share of 46.2% by 2025. This is primarily driven by the growing clinical evidence supporting the use of PARP inhibitors in patients with BRCA-mutated breast cancer. PARP inhibitors like Olaparib have been approved for use in treating BRCA-mutated breast cancer, further cementing their importance in oncology. Given the high prevalence of breast cancer globally, the market for PARP inhibitors in this segment is set to expand significantly.

While ovarian cancer remains a prominent segment, with PARP inhibitors showing efficacy in patients with HRD-positive tumors, the potential for market growth in ovarian cancer is somewhat restricted. Only a portion of ovarian cancer patients are eligible for PARP inhibitor therapies, which limits the growth of this segment compared to breast cancer.

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Regional Insights
North America

North America is projected to dominate the PARP inhibitor biomarkers market, holding a share of 42.7% in 2025. The U.S., in particular, has one of the highest rates of BRCA-related cancers, including breast and ovarian cancers, which directly drives the demand for PARP inhibitor biomarker testing. With more than 4 million women in the U.S. having a history of breast cancer, the country is a major consumer of BRCA testing kits. Furthermore, the growing focus on precision oncology and companion diagnostics in the U.S. healthcare system further accelerates the market's growth.

Europe

Europe is also a significant contributor to the market, accounting for a share of 28.4% in 2025. This can be attributed to the widespread adoption of genetic testing and personalized cancer therapies in the region. Countries like Germany, the U.K., and France have seen a substantial rise in the number of oncology centers offering biomarker-driven therapies. The region's strong regulatory frameworks, coupled with collaborations between pharmaceutical companies and research institutions, continue to foster market growth.

Asia Pacific

Asia Pacific is expected to experience the fastest growth, with a projected CAGR of 9.6% from 2025 to 2032. Japan, China, and India are leading the charge due to increasing government support for precision medicine and a rising focus on oncology research. Japan, in particular, has shown promising results in BRCA testing, with a significant percentage of ovarian cancer patients exhibiting gBRCA mutations. The government's backing of initiatives like the Japan Agency for Medical Research and Development (AMED) is likely to boost demand for PARP inhibitors in the region.

Market Drivers

The market's growth is being propelled by several factors. Increasing cancer prevalence, particularly cancers associated with genetic mutations, is a major driver. With over 18 million new cancer cases diagnosed annually, the need for innovative treatments like PARP inhibitors is growing. Additionally, the rise of personalized medicine and targeted therapies offers more precise treatment options based on individual genetic profiles. As more biomarker tests are developed, clinicians can offer more effective and customized treatments, which enhances patient outcomes.

Market Restraints

Despite the promising outlook, the market faces several challenges. PARP inhibitor resistance is one of the most significant hurdles. Over time, cancer cells may develop resistance to PARP inhibitors, reducing their efficacy. Additionally, identifying patients beyond BRCA mutations who may benefit from PARP inhibitor therapy is still a challenge. While biomarkers for other mutations are being discovered, identifying a broad patient base requires the development of more comprehensive and affordable testing methods.

Market Opportunities

The market also presents significant growth opportunities. The expansion of clinical applications for PARP inhibitors in cancers beyond breast and ovarian cancer is a major opportunity. Additionally, the rise in clinical trials exploring PARP inhibitors' potential in combination with immunotherapies could further boost the market. With more than 300 clinical trials underway, the potential for new approvals and indications is substantial, creating new avenues for both pharmaceutical companies and diagnostic firms to innovate.

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Reasons to Buy the Report

• Gain insights into the market size and forecast for the PARP inhibitor biomarkers market from 2025 to 2032.
• Understand market segmentation by product type and application, helping to identify growth opportunities.
• Explore the competitive landscape, including key market players and their strategies.
• Identify key growth drivers and challenges shaping the market's future.
• Get a deep understanding of regional trends, especially in North America, Europe, and Asia Pacific.

Frequently Asked Questions (FAQs)

• How Big is the PARP Inhibitor Biomarkers Market?
• Who are the Key Players in the Global Market for PARP Inhibitor Biomarkers?
• What is the Projected Growth Rate of the PARP Inhibitor Biomarkers Market?
• What is the Market Forecast for PARP Inhibitor Biomarkers for 2032?
• Which Region is Estimated to Dominate the Industry through the Forecast Period?

Company Insights

Key players in the PARP inhibitor biomarkers market include:
• Myriad Genetics, Inc.
• Illumina, Inc.
• Amoy Diagnostics Co., Ltd.
• QIAGEN
• Agilent Technologies, Inc.

Recent Developments

Myriad Genetics, Inc. acquired assets from Intermountain Health, including the PreciseTM Tumor Test, expanding its offering in PARP inhibitor biomarker testing.

Amoy Diagnostics Co., Ltd. collaborated with AstraZeneca to commercialize the AmoyDx® HRD Complete Panel as the companion diagnostic for the PARP inhibitor Lynparza® (olaparib).

The PARP inhibitor biomarkers market is witnessing remarkable growth, underpinned by advancements in personalized cancer therapies and biomarker-driven diagnostics. The combination of innovative technologies, strategic collaborations, and the increasing demand for precision oncology treatments is set to drive the market forward in the coming years.

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