TIL Therapy Pipeline Insight 2025: Harnessing Tumor-Infiltrating Lymphocytes to Redefine Cancer Immunotherapy | DelveInsight

DelveInsight's "TIL Therapy - Pipeline Insight, 2025" provides an in-depth look at the rapidly expanding field of tumor-infiltrating lymphocyte (TIL) therapy, an adoptive cell therapy approach that utilizes a patient's own immune cells to recognize and attack tumors. Initially pioneered in melanoma, TIL therapy is now being explored across a wide range of solid tumors, offering a promising avenue for patients with limited treatment options.

The pipeline highlights next-generation TIL therapies optimized with improved expansion protocols, genetic modifications, and combination strategies with immune checkpoint inhibitors to enhance durability and response rates. Advances in manufacturing technologies are also helping to scale production, reduce turnaround times, and improve accessibility.

Ongoing clinical trials are evaluating efficacy in melanoma, cervical cancer, non-small cell lung cancer, and other solid tumors, with endpoints including objective response rates, progression-free survival, and overall survival. Early results have shown durable responses in heavily pretreated patients, underscoring the transformative potential of TIL therapy.

Backed by breakthrough and fast-track designations, regulatory momentum is strong, and late-stage candidates are moving closer to commercialization. With its ability to deliver personalized, durable, and potent immune responses, TIL therapy is emerging as a key pillar in the future of cancer immunotherapy.

Interested in learning more about the current treatment landscape and the key drivers shaping the TIL Therapy pipeline? Click here: https://www.delveinsight.com/report-store/til-therapy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Key Takeaways from the TIL Therapy Pipeline Report
• DelveInsight's TIL Therapy pipeline analysis depicts a strong space with 15+ active players working to develop 20+ pipeline drugs for TIL Therapy treatment.
• The leading TIL Therapy companies include TILT Therapeutics, Grit Biotechnology, Instil Bio, Iovance Biotherapeutics, Lyell Immunopharma, Phio Pharmaceuticals, Turnstone Biologics, Shanghai Gencells Therapeutics, Shanghai OriginCell Therapeutics, AgonOx, Obsidian Therapeutics, Nurix Therapeutics, KSQ Therapeutics, Genocea, Achilles Therapeutics, and others are evaluating their lead assets to improve the TIL Therapy treatment landscape.
• Key TIL Therapy pipeline therapies in various stages of development include TILT-123, TIL therapy, ITIL-306, ITIL-168, LN-145, LYL845, PH-762, TIDAL+RIVAL, Lifileucel, Tumor Infiltrating Lymphocytes, AGX-148, cytoTIL, DeTIL-0255, KSQ-001, KSQ-004, GEN-011, and others.
• In July 2025, a five-year study of lifileucel (TIL therapy) in advanced melanoma showed durable responses: a 31.4% objective response rate with a median response duration of roughly three years, reinforcing the long-term efficacy of this one-time treatment.
• In March 2025, NIH researchers reported that a personalized TIL therapy combined with pembrolizumab led to tumor reduction in 25% of patients with gastrointestinal (GI) cancers - marking a promising advance in solid tumor immunotherapy.
• In March 2025, scientists at the University of Texas at Austin and collaborators identified antibodies capable of neutralizing a wide range of norovirus strains, a key step toward broadly protective vaccine development.

Request a sample and discover the recent breakthroughs happening in the TIL Therapy pipeline landscape at https://www.delveinsight.com/report-store/til-therapy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

TIL Therapy Overview
Tumor-Infiltrating Lymphocyte (TIL) therapy is an immunotherapy approach that uses a patient's own immune cells to fight cancer. TILs are immune cells that have naturally migrated into a tumor but may be suppressed by the tumor environment. In TIL therapy, these lymphocytes are extracted from a patient's tumor, expanded to large numbers in the lab, and then infused back into the patient to boost the immune system's ability to attack cancer cells. This therapy has shown promise especially in treating melanoma and certain other solid tumors.

The process typically involves surgical removal of tumor tissue, isolation and growth of TILs, sometimes combined with immune-stimulating treatments like interleukin-2, and often lymphodepleting chemotherapy before reinfusion to improve TIL survival. While still largely experimental, TIL therapy represents a personalized and targeted way to enhance the body's natural defenses against cancer.

Find out more about TIL Therapy medication at https://www.delveinsight.com/report-store/til-therapy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

TIL Therapy Treatment Analysis: Drug Profile
LN-145: Iovance Therapeutics
LN-145 is an autologous tumor-infiltrating lymphocyte (TIL) therapy developed by isolating a patient's own naturally occurring TILs from a cancerous tumor sample. These TILs are then expanded and engineered in the lab before being infused back into the patient intravenously as LN-145. The goal is for the infused TILs to target and attack the patient's cancer more effectively by increasing their number and activity. LN-145 is currently in Phase II clinical trials for several cancers, including cervical cancer, colorectal cancer, head and neck cancer, malignant melanoma, and non-small cell lung cancer.

ITIL-168: Instil Bio
ITIL-168 is an investigational autologous TIL therapy produced using Instil Bio's proprietary, optimized, and scalable manufacturing process. This method is designed to preserve the maximum diversity of each patient's TILs and provides flexible scheduling options for both tumor removal and TIL treatment. ITIL-168 is currently being evaluated in Phase II clinical trials for the treatment of malignant melanoma.

Learn more about the novel and emerging TIL Therapy pipeline therapies at https://www.delveinsight.com/report-store/til-therapy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

TIL Therapy Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Oral
• Parenteral
• Intravenous
• Subcutaneous
• Topical

By Molecule Type
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy

Scope of the TIL Therapy Pipeline Report
• Coverage: Global
• Key TIL Therapy Companies: TILT Therapeutics, Grit Biotechnology, Instil Bio, Iovance Biotherapeutics, Lyell Immunopharma, Phio Pharmaceuticals, Turnstone Biologics, Shanghai Gencells Therapeutics, Shanghai OriginCell Therapeutics, AgonOx, Obsidian Therapeutics, Nurix Therapeutics, KSQ Therapeutics, Genocea, Achilles Therapeutics, and others.
• Key TIL Therapy Pipeline Therapies: TILT-123, TIL therapy, ITIL-306, ITIL-168, LN-145, LYL845, PH-762, TIDAL+RIVAL, Lifileucel, Tumor Infiltrating Lymphocytes, AGX-148, cytoTIL, DeTIL-0255, KSQ-001, KSQ-004, GEN-011, and others.

To dive deep into rich insights for drugs used for TIL Therapy treatment, visit: https://www.delveinsight.com/report-store/til-therapy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Table of Contents
1. Introduction
2. Executive Summary
3. TIL Therapy Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. TIL Therapy Pipeline Therapeutics
6. TIL Therapy Pipeline: Late-Stage Products (Phase III)
7. TIL Therapy Pipeline: Mid-Stage Products (Phase II)
8. TIL Therapy Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

Contact Us:
Jatin Vimal
jvimal@delveinsight.com
+14699457679
Healthcare Consulting
https://www.delveinsight.com/consulting-services

About DelveInsight
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This release was published on openPR.