Soaring Demand Set to Propel Cementless Total Knee Arthroplasty Market to $4.64 Billion by 2029

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What Is the Expected CAGR for the Cementless Total Knee Arthroplasty Market Through 2025?
The size of the cementless total knee arthroplasty market has seen rapid expansion in the recent years. An escalation from $2.63 billion in 2024 to $2.95 billion in 2025 is expected, with a compound annual growth rate (CAGR) of 12.3%. The growth during the historic period could be because of the increasing preference for durable orthopedic implants, the rising popularity of biologically integrated joint replacements, an increase in knee replacement surgeries among younger patients, expanding elderly population, and heightened awareness about implant longevity.

What's the Projected Size of the Global Cementless Total Knee Arthroplasty Market by 2029?
The market size of cementless total knee arthroplasty is poised to experience swift growth in the coming years, forecasted to reach a value of $4.64 billion in 2029 with a compound annual growth rate (CAGR) of 12.0%. Various factors driving this emerging market include the increasing preference for individualized knee implant designs, growing needs for revision-compatible knee replacement options, a focus on minimizing complications from implant looseness, proliferation of outpatient orthopedic surgical facilities, and increased healthcare spending. Key trends to anticipate in this growth period comprise the inclusion of robotic-assisted alignment in cementless knee operations, acceptance of 3D printed custom-fit cementless implants, the application of cutting-edge biomimetic coatings boosting osseointegration, the emergence of modular component designs enabling flexible adjustments during surgery, and the creation of bioactive surface coatings.

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Top Growth Drivers in the Cementless Total Knee Arthroplasty Industry: What's Accelerating the Market?
The surge in knee osteoarthritis cases is set to boost the cementless total knee arthroplasty market's expansion. Knee osteoarthritis, a disease that deteriorates joints and renders pain, swelling, and inflexibility in the knee joint, impairs mobility. The escalating occurrence of this ailment largely stems from the upsurge in obesity, which exacerbates the strain on knee joints due to excess weight, hastening the deterioration of cartilage and joints. Cementless total knee arthroplasty addresses knee osteoarthritis by substituting the impaired joint surfaces with prosthetic parts, promoting natural bone regeneration resulting in sustained stability and enhanced joint performance. The Office for Health Improvement and Disparities, a UK governmental agency, stated in March 2023 that 17.6% of individuals aged 16 and above in 2022 reported experiencing a long-term musculoskeletal (MSK) disorder, including arthritis or enduring back or joint issues - a rise from 17.0% in 2021. Consequently, the escalating frequency of knee osteoarthritis is energizing the cementless total knee arthroplasty market's growth.

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What Long-Term Trends Will Define the Future of the Cementless Total Knee Arthroplasty Market?
Leading businesses in the cementless total knee arthroplasty domain are centering their efforts on creating innovative items like next-gen 3D-printed implants. These products are aimed at stimulating bone growth, improving the durability of implant fixation, and meeting the needs of younger, more active individuals. Next-gen 3D-printed implants are cutting-edge orthopedic tools produced using additive manufacturing techniques. They feature porous structures that imitate actual bone, thereby augmenting biological fixation by fostering bone growth into the implant surface for better long-term stability without the need for bone cement. An example of this is from March 2022, when DePuy Synthes Sales Inc., a US-based medical device firm, rolled out the Attune cementless fixed bearing knee equipped with affixium 3DP technology. This is a next-gen 3D-printed cementless knee implant engineered for superior biological fixation and improved initial implant stability, catering particularly to active individuals. It utilizes a lattice structure whose porosity bears a close resemblance to natural bone. This breakthrough is a part of the company's extensive Attune knee product range and is in sync with the growing shift towards cementless fixation. This seeks to improve patient results, lower revision rates, and cater to the functionality requirements of a younger, more agile patient demographic.

What Are the Main Segments in the Cementless Total Knee Arthroplasty Market?
The cementless total knee arthroplasty market covered in this report is segmented

1) By Product: Fixed-Bearing, Mobile-Bearing
2) By Material: Titanium, Cobalt-Chromium, Polyethylene, Ceramic
3) By Distribution Channels: Direct Sales, Distributors And Resellers
4) By Application: Primary Total Knee Arthroplasty, Revision Total Knee Arthroplasty
5) By End User: Hospitals, Specialty Clinics, Ambulatory Surgery Centers, Other End Users

Subsegments:
1) By Fixed-Bearing: Posterior Stabilized Fixed-Bearing, Cruciate Retaining Fixed-Bearing, Medial Pivot Fixed-Bearing
2) By Mobile-Bearing: Rotating Platform Mobile-Bearing, Meniscal Bearing Mobile-Bearing, Dual Mobility Mobile-Bearing

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Which Top Companies are Driving Growth in the Cementless Total Knee Arthroplasty Market?
Major companies operating in the cementless total knee arthroplasty market are Johnson & Johnson, Stryker Corporation, Zimmer Biomet Holdings Inc., Smith & Nephew Plc, Enovis Corporation, CONMED Corporation, Globus Medical Inc., MicroPort Scientific Corporation, Medacta Group SA, B. Braun Melsungen SE, TTK Healthcare Limited, Waldemar Link GmbH & Co. KG, United Orthopedic Corporation, Symbios Orthopédie SA, Gruppo Bioimpianti S.p.A., Permedica Orthopaedics S.p.A., Uteshiya Medicare Private Limited, LINK Orthopaedics GmbH, Plus Orthopaedics India Pvt. Ltd., and XLO India Pvt. Ltd.

Which Regions Will Dominate the Cementless Total Knee Arthroplasty Market Through 2029?
North America was the largest region in the cementless total knee arthroplasty market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the cementless total knee arthroplasty market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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