Press release
Emerging Trends to Drive Non-Viral Gene Delivery Technologies Market Growth at 15.2% CAGR Through 2029
Non Viral Gene Delivery Technologies
Non-Viral Gene Delivery Technologies Market Size Growth Forecast: What to Expect by 2025?
The market size of non-viral gene delivery technologies has seen a swift increase in the past few years, expanding from $3.96 billion in 2024 to $4.57 billion in 2025, reflecting a compound annual growth rate (CAGR) of 15.6%. Factors such as the broadening scope of genetic research, escalating occurrence of chronic genetic disorders, burgeoning R&D in the pharmaceutical and biotechnology sectors, rising interest in genetic and molecular biology research, and augmented funding from the government and institutions have all contributed to this historic growth.
How Will the Non-Viral Gene Delivery Technologies Market Size Evolve and Grow by 2029?
Expectations predict a significant expansion in the market size of non-viral gene delivery technologies over the upcoming years, reaching a worth of $8.06 billion in 2029 with a compound annual growth rate (CAGR) of 15.2%. Factors contributing to this forecasted growth include the heightened demand for personalized medicine, an increase in utilisation within cancer and rare disease research, the emergence and application of clustered regularly interspaced short palindromic repeats and gene editing technologies, the swift proliferation of mRNA-based therapeutics, and developments in cell therapy and tissue engineering. Trends to look out for within this period encompass advancements in lipid nanoparticles and polymer-based vectors, progression in the creation of deoxyribonucleic acid and ribonucleic acid therapeutics, incorporation of artificial intelligence and computational modeling, the next wave of lipid nanoparticles (LNPs), and progress in the field of nanotechnology.
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What Drivers Are Propelling the Growth of Non-Viral Gene Delivery Technologies Market Forward?
As we see a surge in the demand for personalized medicine, the non-viral gene delivery technologies market is poised for significant growth. Also known as precision medicine, personalized medicine is a medical model that tailors prevention, diagnosis, and treatment plans based on an individual's genetics, lifestyle, and environmental factors. The interest in personalized medicine is driven by advancements in genomic sequencing technologies, allowing for a more precise diagnosis, focused therapies, and enhanced individualized treatment outcomes. As a result, this stems the demand for non-viral gene delivery technologies, providing safer and more adjustable ways of transferring therapeutic genes, tailored to an individual's genetics, and without the associated risks of viral vectors. For instance, in February 2024, the Personalized Medicine Coalition, a non-profit based in the US, stated that the FDA had granted approval to 16 new personalized therapies designed for patients with rare diseases in 2023, compared to 6 in 2022. Hence, the surging interest in personalized medicine is stimulating the growth of the non-viral gene delivery technologies market.
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Which Fast-Growing Trends Are Poised to Disrupt the Non-Viral Gene Delivery Technologies Market?
Prominent enterprises in the non-viral gene delivery market are concentrating on the creation of advanced solutions like non-viral genetic medicine platforms. These advance the safety and effectiveness of gene therapies. A non-viral genetic medicine platform introduces therapeutic genes or nucleic acids into cells without the use of viruses, lessening immune reactions and concerns about safety. It also allows for accurate and regulated gene therapy delivery for a myriad of diseases. For instance, Generation Bio Co., a biotechnology firm based in the US that focuses on genetic medicines, unveiled its immune-quiet DNA (iqDNA) in October 2023. This innovative DNA is a refined version of their closed-ended DNA (ceDNA) that manages to evade innate immune detection, exhibiting levels of cytokine and tolerance on par with chemically modified mRNA in mice and non-human primates when delivered through their lipid nanoparticle (LNP) system. As a result of the outstanding tolerability of iqDNA, Generation Bio is progressing this as the main DNA cargo in all its projects, which includes their primary hemophilia A initiative.
What Are the Key Segments in the Non-Viral Gene Delivery Technologies Market?
The non-viral gene delivery technologies market covered in this report is segmented
1) By Product: Reagents And Kits, Delivery Devices, Pre-Formulated Nanoparticles
2) By Delivery: In-Vitro, In-Vivo, Ex-Vivo
3) By Technology: Electroporation, Lipid-Based Transfection, Polymer-Based Transfection, Physical Methods (Microinjection, Gene Gun), Nanoparticles
4) By Application: Gene Therapy, Deoxyribonucleic Acid (DNA) Vaccines, Ribonucleic Acid Interference (RNAi), Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Or Cas9 Gene Editing, Protein Expression
5) By End-Use: Biotechnology And Biopharmaceutical Companies, Research And Academic Institutes, Other End-Uses
Subsegments:
1) By Reagents And Kits: Transfection Reagents, Plasmid Deoxyribonucleic Acid (DNA) Kits, Messenger Ribonucleic Acid (RNA) Delivery Kits, Small Interfering Ribonucleic Acid (RNA) Delivery Kits, Clustered Regularly Interspaced Short Palindromic Repeats Associated Protein Reagents, Cell-Specific Delivery Reagents
2) By Delivery Devices: Electroporation Systems, Microinjection Systems, Gene Guns Or Biolistic Delivery Devices, Ultrasound-Mediated Delivery Devices, Hydrodynamic Gene Delivery Systems
3) By Pre-Formulated Nanoparticles: Lipid-Based Nanoparticles, Polymer-Based Nanoparticles, Gold-Based Nanoparticles, Dendrimer-Based Nanoparticles, Carbon Nanotube-Based Nanoparticles, Inorganic Compound-Based Nanoparticles
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Who Are the Key Players Shaping the Non-Viral Gene Delivery Technologies Market's Competitive Landscape?
Major companies operating in the non-viral gene delivery technologies market are Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, Evonik Industries AG, Moderna Inc., Boehringer Ingelheim GmbH, Agilent Technologies Inc., Lonza Group AG, Sartorius AG, Bio-Rad Laboratories Inc., Bio-Techne Corp., Takara Bio Inc., GenScript Biotech Corporation, Poseida Therapeutics Inc., ElevateBio LLC, ProBio Inc., ReCode Therapeutics Inc., Altogen Biosystems Inc., Generation Bio, Indee Labs Inc.
What Geographic Markets Are Powering Growth in the Non-Viral Gene Delivery Technologies Market?
North America was the largest region in the non-viral gene delivery technologies market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the non-viral gene delivery technologies market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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