Driving Deoxyribonucleic Acid (DNA) Manufacturing Market Growth in 2025: The Role of Increasing Demand For Gene Therapies Fueling The Growth Of The Market Due To Rising Prevalence Of Genetic Disorders

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Deoxyribonucleic Acid (DNA) Manufacturing Market Size Growth Forecast: What to Expect by 2025?
In recent times, the market size for deoxyribonucleic acid (DNA) manufacturing has surged significantly. The value is expected to increase from $4.77 billion in 2024 to $5.58 billion in 2025, reflecting a compound annual growth rate (CAGR) of 16.9%. Factors stimulating growth during the historic period include the emergence of genomics-based research, the expansion of biotechnology and biopharma sectors, a rise in contract manufacturing organizations (CMOs), advancements in CRISPR and gene editing applications, and numerous government initiatives and funding.

How Will the Deoxyribonucleic Acid (DNA) Manufacturing Market Size Evolve and Grow by 2029?
The market for manufacturing deoxyribonucleic acid (DNA) is projected to witness substantial expansion in the upcoming years, with expectations to reach $10.28 billion by 2029, recording a compound annual growth rate (CAGR) of 16.5%. The driving factors for this escalated growth during the forecast period include the progression in cell and gene therapy pipelines, heightened drug discovery efforts, rising biodefense, increased expenditure on pandemic readiness, and the worldwide expansion of biomanufacturing supply chains. Key tendencies during the forecast period consist of convergence with next-generation sequencing (NGS), breakthroughs in mRNA and DNA vaccines, enhancements in high-fidelity and long-read synthesis, integration of automation and robotics in DNA manufacturing, and the evolution of next-generation enzymatic DNA synthesis (EDS).

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What Drivers Are Propelling the Growth of Deoxyribonucleic Acid (DNA) Manufacturing Market Forward?
The surging need for gene therapies is anticipated to boost the expansion of the deoxyribonucleic acid (DNA) manufacturing market. Gene therapies are procedures which amend or substitute faulty genes to prevent or cure diseases, and personalized medicine caters medical treatments based on an individual's genetic, biological, and lifestyle characteristics. The growing need for gene therapies is a consequence of the increased prevalence of genetic abnormalities like cystic fibrosis, sickle cell anemia, and certain inherited blindness forms. Deoxyribonucleic acid (DNA) manufacturing bolsters gene therapies by providing the custom, high-quality DNA sequences required to engineer and apply therapeutic genes that have the potential to amend or substitute faulty genes in patients. For example, records from the Association of the British Pharmaceutical Industry from August 2024 indicate that the individuals in the UK eligible for gene therapy treatment are forecasted to surge from 2,500 in 2021 up to 10,000 per year by 2028. This implies that the escalating need for gene therapies is fuelling the expansion of the deoxyribonucleic acid (DNA) manufacturing market.

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What Long-Term Trends Will Define the Future of the Deoxyribonucleic Acid (DNA) Manufacturing Market?
A primary focus for major players in the DNA manufacturing market is the development of innovative methods like GMP-grade plasmid DNA production. This approach aims to increase the safety, quality, and scalability of gene and cell therapy applications. GMP-grade plasmid DNA production involves the production of plasmid DNA in accordance with Good Manufacturing Practice (GMP) standards that guarantee the consistency, safety, and quality of biopharmaceutical products. For example, ProBio Genomics Inc., a US-based contract development and manufacturing firm, introduced its GMP Plasmid DNA Manufacturing Services in Hopewell in April 2025. These services come with a suite of in-house options such as analytical testing, method development, and project management to eliminate dependency on multiple suppliers and fast-track the development process. This service assures top-quality outcomes with supercoiled plasmid DNA content of at least 85%, while also considerably reducing the risk of contamination. Furthermore, ProBio provides GMP-like plasmids within a four-week time frame and full GMP-grade plasmids within three months.

What Are the Key Segments in the Deoxyribonucleic Acid (DNA) Manufacturing Market?
The deoxyribonucleic acid (DNA) manufacturing market covered in this report is segmented

1) By Type: Plasmid Deoxyribonucleic Acid (DNA), Synthetic Deoxyribonucleic Acid (DNA), Gene Synthesis, Oligonucleotide Synthesis
2) By Grade: Good Manufacturing Practices (GMP) Grade, Research And Development Grade
3) By Application: Cell And Gene Therapy, Vaccines, Oligonucleotide-Based Drugs, Other Applications
4) By End-Use: Pharmaceutical And Biotechnology Companies, Academic And Research Institutes, Contract Research Organizations

Subsegments:
1) By Plasmid Deoxyribonucleic Acid (DNA): GMP-Grade Plasmid DNA, Non-GMP-Grade Plasmid DNA, High Copy Number Plasmids, Low Copy Number Plasmids, Bacterial Fermentation-Based Plasmid Production, Transfection-Grade Plasmid DNA
2) By Synthetic Deoxyribonucleic Acid (DNA): Enzymatic DNA Synthesis, Chemical DNA Synthesis, Long DNA Fragments, Short DNA Fragments, Single-Stranded Synthetic DNA, Double-Stranded Synthetic DNA
3) By Gene Synthesis: Custom Gene Synthesis, Standard Gene Synthesis, Complex Gene Constructs, Codon Optimization Services, Gene Library Synthesis
4) By Oligonucleotide Synthesis: DNA Oligonucleotides, Modified Oligonucleotides, Long Oligonucleotides, PCR Primers, SiRNA And Antisense Oligos, Adapter And Linker Oligos

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Who Are the Key Players Shaping the Deoxyribonucleic Acid (DNA) Manufacturing Market's Competitive Landscape?
Major companies operating in the deoxyribonucleic acid (DNA) manufacturing market are Thermo Fisher Scientific Inc., Merck KGaA, Lonza Group AG, Kaneka Corporation, Catalent Inc., Charles River Laboratories International Inc., WuXi Biologics Inc., AGC Biologics Inc., Integrated DNA Technologies Inc., GenScript Biotech Corporation, Takara Bio USA Inc., Twist Bioscience Corp., Ajinomoto Bio-Pharma Services, OriGene Technologies Inc., DNA Script SAS, Eurofins Genomics LLC, Touchlight Genetics Ltd., Elegen Inc., VGXI Inc., PlasmidFactory GmbH & Co. KG.

What Geographic Markets Are Powering Growth in the Deoxyribonucleic Acid (DNA) Manufacturing Market?
North America was the largest region in the deoxyribonucleic acid (DNA) manufacturing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the deoxyribonucleic acid (DNA) manufacturing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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