Canada's market for moderate to severe plaque psoriasis is expected to reach USD 4.6 billion by 2034.

Plaque psoriasis is a chronic autoimmune skin disorder characterized by raised, red, scaly patches of skin, most commonly on the elbows, knees, and scalp. Moderate to severe forms of the disease require long-term treatment, with therapies ranging from systemic drugs to advanced biologics. In Canada, plaque psoriasis affects a significant portion of the population, with moderate to severe cases accounting for nearly 25-30% of total psoriasis patients.

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With increased awareness, improved access to biologics, and supportive healthcare policies, the Canadian market for moderate to severe plaque psoriasis is experiencing substantial growth. In 2024, the Canadian market is valued at USD 1.9 billion. By 2034, it is projected to reach USD 4.6 billion, expanding at a compound annual growth rate (CAGR) of 9.2% between 2025 and 2034.

This growth trajectory reflects not only advances in immunology but also Canada's unique healthcare environment, which emphasizes equitable access through public and private reimbursement mechanisms.

Market Overview
• Market Size (2024): USD 1.9 billion (Canada)
• Forecasted Market Size (2034): USD 4.6 billion
• CAGR (2025-2034): 9.2%
• Key Drivers: Rising prevalence of autoimmune skin conditions, biologics adoption, government reimbursement programs, and patient advocacy efforts.
• Key Challenges: High cost of biologics, regional disparities in access across provinces, and safety concerns with long-term immunosuppressive therapy.
• Leading Players: Novartis AG, AbbVie Inc., Johnson & Johnson (Janssen), Amgen Inc., Eli Lilly & Co., Pfizer Inc., Bristol Myers Squibb (BMS), UCB Pharma, Sun Pharma, and Leo Pharma.

Canada's psoriasis market reflects the global trend of biologic therapies dominating treatment while small molecules and topical therapies play supportive roles.

Segmentation Analysis
The Canadian moderate to severe plaque psoriasis market can be segmented by product, platform, technology, end use, and application.

By Product
• Biologics
o TNF-alpha inhibitors (etanercept, adalimumab, infliximab)
o IL-17 inhibitors (secukinumab, ixekizumab)
o IL-23 inhibitors (guselkumab, risankizumab, tildrakizumab)
o IL-12/23 inhibitors (ustekinumab)
• Small molecule therapies (apremilast, deucravacitinib)
• Traditional systemic drugs (methotrexate, cyclosporine, acitretin)
• Phototherapy adjuncts
• Topical therapies (used in combination for moderate cases)

By Platform
• Biopharmaceuticals (monoclonal antibodies, fusion proteins)
• Small molecules (oral PDE4 and TYK2 inhibitors)
• Combination therapies

By Technology
• Traditional immunosuppressants
• Biologics targeting cytokine pathways
• Next-generation immunomodulators (TYK2 inhibitors, biosimilars)
• Digital health and teledermatology integration

By End Use
• Hospitals and specialty dermatology centers
• Community clinics
• Retail and specialty pharmacies
• Telehealth and homecare platforms

By Application
• Plaque psoriasis (moderate to severe)
• Psoriatic arthritis overlap
• Refractory/resistant psoriasis cases

Segmentation Summary
Biologics account for the largest share of the Canadian market, while IL-23 inhibitors and TYK2 inhibitors represent the fastest-growing product segments. Traditional systemic therapies remain in use, particularly for cost-sensitive patients or those with contraindications to biologics.

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Regional Insights - Focus on Canada
The Canadian healthcare system is a blend of public and private payers, making drug access and reimbursement pivotal market factors.
• Ontario and Quebec: Represent the largest provincial markets due to population size and extensive healthcare infrastructure. Both provinces have strong biologic reimbursement frameworks under their public drug plans.
• Western Canada (Alberta, British Columbia): High prevalence of psoriasis, with Alberta being a hub for clinical research and biologic adoption.
• Atlantic Canada: Smaller but growing market, with increasing access to newer biologics via federal and provincial initiatives.
• Northern Territories: Limited dermatology infrastructure; patients often face delays in diagnosis and treatment access.
North American Context
Compared to the U.S., where cost barriers are higher, Canada's reimbursement system provides relatively broader access to biologics, though with variability between provinces. This ensures steady adoption growth, especially for next-generation therapies.

Market Dynamics
Key Growth Drivers
1. Adoption of Biologics: IL-17 and IL-23 inhibitors are now standard of care for many moderate to severe patients.
2. Reimbursement Policies: Federal and provincial drug plans increasingly cover high-cost therapies, reducing out-of-pocket expenses.
3. Rising Awareness: Patient advocacy groups (e.g., Canadian Psoriasis Network) are improving education and early diagnosis.
4. Pipeline Innovation: TYK2 inhibitors and biosimilars expanding therapeutic choices.
5. Digital Health Expansion: Teledermatology improving access in remote areas.

Key Challenges
1. High Biologic Costs: Despite reimbursement, pricing remains a challenge for healthcare budgets.
2. Provincial Disparities: Access and approval timelines vary between provinces.
3. Safety Concerns: Long-term immunosuppression raises infection risk and monitoring needs.
4. Treatment Adherence: Complex biologic regimens may impact adherence rates.

Latest Trends
• TYK2 Inhibitors: Oral therapy (deucravacitinib) gaining attention for convenience and efficacy.
• Biosimilars: Increasing entry of infliximab and adalimumab biosimilars, improving affordability.
• Patient-Centered Trials: Emphasis on quality-of-life measures alongside PASI (Psoriasis Area Severity Index) scores.
• Combination Approaches: Topicals and phototherapy used alongside biologics for holistic care.
• Digital Engagement: Mobile apps and virtual platforms supporting patient adherence.

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Competitor Analysis
Key Players in the Canadian Psoriasis Market:
• Novartis AG - Secukinumab (Cosentyx) and bimekizumab pipeline.
• AbbVie Inc. - Adalimumab (Humira) and risankizumab (Skyrizi).
• Johnson & Johnson (Janssen) - Ustekinumab (Stelara) and guselkumab (Tremfya).
• Amgen Inc. - Etanercept (Enbrel) and biosimilars.
• Eli Lilly & Co. - Ixekizumab (Taltz).
• Pfizer Inc. - TYK2 and JAK inhibitor pipeline.
• Bristol Myers Squibb (BMS) - Deucravacitinib (oral TYK2 inhibitor).
• UCB Pharma - Bimekizumab, dual IL-17A/IL-17F inhibitor.
• Sun Pharma & Leo Pharma - Topical therapies and phototherapy adjuncts.

Competitive Summary
The market is competitive but concentrated around biologic leaders (Novartis, AbbVie, J&J, Lilly). Biosimilars and TYK2 inhibitors are expected to intensify competition, while smaller dermatology firms play key roles in topicals and supportive care.

Conclusion
The Canadian moderate to severe plaque psoriasis market is set to grow from USD 1.9 billion in 2024 to USD 4.6 billion by 2034, expanding at a CAGR of 9.2%. This strong growth is driven by biologic innovation, supportive reimbursement frameworks, and rising patient advocacy.
• Biologics and next-generation immunotherapies will remain the cornerstone of treatment.
• Provincial disparities and high costs present ongoing challenges, but biosimilars and digital health may provide solutions.
• Asia-Pacific-style innovations (e.g., telehealth models) are increasingly relevant for Canada's rural and remote regions.

In summary, the Canadian psoriasis market reflects the evolution of dermatology toward targeted, patient-centric, and accessible care. Companies that focus on affordability, innovation, and patient engagement will be best positioned to capture growth in this expanding market.

This report is also available in the following languages : Japanese (中等度から重度の尋常性乾癬(カナダのみのデータ)市場), Korean (중등도~중증 플라크 건선(캐나다 데이터만 해당) 시장), Chinese (中度至重度斑块性银屑病(仅加拿大数据)市场), French (Marché du psoriasis en plaques modéré à sévère (DONNÉES DU CANADA UNIQUEMENT)), German (Markt für mittelschwere bis schwere Plaque-Psoriasis (NUR DATEN AUS KANADA)), and Italian (Mercato della psoriasi a placche da moderata a grave (SOLO DATI CANADA)), etc.

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