GLP-1 Market Growth and Restrain Factors Analysis Report

InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the "Global GLP-1 Market Size, Share & Trends Analysis Report By Type of Molecule (Biologics and Small Molecules), Active Compound Used (Dulaglutide, Liraglutide, Orforglipron, Retatrutide, Semaglutide, Survodutide, Tirzepatide and Other Active Compounds), Type of GLP-1 Agonist Drugs (Long-acting GLP-1 Agonist and Short-acting GLP-1 Agonist), Type of Agonist (Single-agonist, Dual-agonist and Tri-agonist), Route of Administration (Oral and Parenteral), Target indication (Alzheimer's Disease, Non-Alcoholic Steatohepatitis, Obesity, Sleep Apnea, Type 2 Diabetes)- Market Outlook And Industry Analysis 2034"

The Global GLP-1 Market is valued at US$ 50.0 Mn in 2024, and it is expected to reach US$ 141.9 Mn by 2034, with a CAGR of 11.1% during the forecast period of 2025-2034.

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Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that plays a pivotal role in glucose metabolism and appetite regulation. GLP-1 receptor agonists are a class of therapeutic agents that stimulate the GLP-1 receptor, leading to enhanced insulin secretion in response to elevated blood glucose levels, suppression of glucagon release, delayed gastric emptying, and improved glucose uptake in peripheral tissues. These mechanisms contribute to improved glycemic control and have proven especially effective in the management of type 2 diabetes.

The market for GLP-1 receptor agonists includes a diverse portfolio of approved and investigational drugs. These range from short-acting agents such as exenatide and lixisenatide, to long-acting formulations like semaglutide, dulaglutide, and liraglutide. Notably, innovations such as oral semaglutide (Rybelsus) have enhanced patient convenience and compliance.

List of Prominent Players in the GLP-1 Market:
• AstraZeneca
• Biolingus
• Boehringer Ingelheim
• D&D Pharmatech
• Eli Lilly
• Gmax Biopharm
• Hanmi Pharmaceutical
• Innogen
• Novo Nordisk
• PegBio
• Pfizer
• QL Biopharma
• Roche
• Sanofi
• Sciwind Biosciences
• Tonghua Dongbao Pharmaceutical
• Viking Therapeutics
• Vivani
• vTv Therapeutic

Market Dynamics:
Drivers-
The rising global prevalence of type 2 diabetes and obesity is a significant driver of growth in the GLP-1 receptor agonist market, with diabetes rates increasing from 3% to 4.1% and obesity rising from 32.7% to 40.9% between 2009 and 2020, according to a study published in the Journal of the American Medical Association. GLP-1 receptor agonists have shown strong efficacy in lowering blood sugar levels, reducing HbA1c, and promoting substantial weight loss in affected patients.

Recent regulatory approvals for treatments like semaglutide (Wegovy) for obesity, in addition to diabetes, have broadened the patient base and further fueled market expansion. Improved insurance coverage and affordability are making these treatments more accessible, while continuous pharmaceutical innovation-including the launch of oral and once-weekly injectable formulations-enhances patient convenience and adherence, addressing unmet healthcare needs.

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Challenges:
GLP-1 receptor agonists face challenges impacting patient adherence, including gastrointestinal side effects like nausea and vomiting, which can deter use. Many require subcutaneous injections, posing convenience issues, though oral options like semaglutide are emerging. While long-acting formulations offer once-weekly dosing, there's a need for even less frequent administration. Additionally, high costs and limited insurance coverage, especially in developing markets, restrict access, underscoring the importance of improving affordability.

Regional Trends:
The APAC region is rapidly emerging as a significant market for GLP-1 receptor agonists, driven by countries such as China, Japan, and India. This growth is supported by an expanding healthcare sector, a large target patient population, and substantial unmet clinical needs for diabetes and obesity treatments. The increasing prevalence of type 2 diabetes and obesity in APAC countries is fueling demand for effective GLP-1 therapies. Additionally, major pharmaceutical companies are focusing on innovative GLP-1 receptor agonist solutions to meet the region's growing healthcare needs.

Recent Developments:
• In November 2023, The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's ZepboundTM (tirzepatide) injection, marking it as the first and only obesity treatment that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors.
• In Dec 2021, Shanghai Innogen Pharma successfully completed a $120 million Series A funding round to support its Phase III trial of supaglutide, a GLP-1 agonist targeting diabetes. The funds will also be used to advance several first-in-class programs and establish a clinical trial manufacturing facility.

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Segmentation of GLP-1 Market-
By Type of Molecule:
• Biologics
• Small Molecules
By Active Compound Used:
• Dulaglutide
• Liraglutide
• Orforglipron
• Retatrutide
• Semaglutide
• Survodutide
• Tirzepatide
• Other Active Compounds
By Type of GLP-1 Agonist Drugs:
• Long-acting GLP-1 Agonist
• Short-acting GLP-1 Agonist
By Type of Agonist:
• Single agonist
• Dual agonist
• Tri-agonist
By Route of Administration:
• Oral
• Parenteral
By Target Indication:
• Alzheimer's Disease
• Non-Alcoholic Steatohepatitis
• Obesity
• Sleep Apnea
• Type 2 Diabetes
By Region-
North America-
• The US
• Canada
• Mexico
Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe
Asia-Pacific-
• China
• Japan
• India
• South Korea
• Southeast Asia
• Rest of Asia Pacific
Latin America-
• Brazil
• Argentina
• Rest of Latin America
Middle East & Africa-
• GCC Countries
• South Africa
• Rest of Middle East and Africa

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