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Pemphigus Vulgaris Market is expected to reach USD 3.4 billion by 2034

09-01-2025 01:21 PM CET | Health & Medicine

Press release from: Exactitude Consultancy

Pemphigus Vulgaris

Pemphigus Vulgaris

Pemphigus vulgaris (PV) is a rare, chronic autoimmune blistering disorder affecting the skin and mucous membranes. Caused by autoantibodies targeting desmogleins, PV leads to painful erosions, significant morbidity, and in untreated cases, life-threatening complications. For decades, treatment relied mainly on corticosteroids and immunosuppressants, which carried severe long-term side effects.

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The therapeutic landscape is evolving with the arrival of biologics such as rituximab, which was the first FDA-approved treatment for PV, and a growing pipeline of novel immunotherapies. As awareness increases, regulatory bodies incentivize rare disease drug development, and patient advocacy strengthens, the global pemphigus vulgaris market is projected to grow steadily through 2034.

Market Overview
• Market Size (2024): USD 1.8 billion
• Forecast (2034): USD 3.4 billion
• CAGR (2025-2034): ~6.6%

• Key Growth Drivers: Increasing adoption of biologics, orphan drug incentives, and rare disease R&D expansion.

• Key Challenges: High cost of therapies, delayed diagnosis, and limited treatment access in developing regions.

• Leading Players: Roche (Genentech), Novartis AG, Sanofi, Regeneron Pharmaceuticals, Pfizer, Amryt Pharma, Argenx, Eli Lilly.

Segmentation Analysis
By Therapy Type
• Corticosteroids
• Immunosuppressants (azathioprine, mycophenolate mofetil, cyclophosphamide)
• Biologics (rituximab, efgartigimod, emerging monoclonal antibodies)
• Intravenous Immunoglobulin (IVIG)
• Plasmapheresis & Adjunctive Therapies

By Route of Administration
• Oral
• Intravenous
• Subcutaneous

By End Use
• Hospitals
• Specialty Clinics
• Research & Academic Institutes
• Homecare

By Distribution Channel
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

Summary: Corticosteroids remain widely used for rapid disease control, but biologics and IVIG are the fastest-growing segments, reflecting higher efficacy in refractory cases.

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Regional Analysis
• North America: Largest share due to strong biologic adoption, FDA-approved therapies, and rare disease funding. The U.S. leads with rituximab uptake and clinical trial participation.
• Europe: Significant share supported by EMA orphan drug designations and national reimbursement policies. Germany, the UK, and France lead the region.
• Asia-Pacific: Fastest-growing region due to rising prevalence, improved healthcare access, and expanding rare disease frameworks in Japan, China, and India.
• Middle East & Africa: Limited but emerging market; GCC nations are improving access via rare disease initiatives.
• Latin America: Brazil and Mexico lead adoption, with increasing participation in global clinical trials.

Summary: North America and Europe dominate the PV market, but Asia-Pacific is expected to post the highest CAGR (~8%) through 2034, reflecting better infrastructure and policy support.

Market Dynamics
Key Growth Drivers
• FDA and EMA approvals of rituximab and other biologics for PV.
• Rising number of clinical trials for FcRn inhibitors and novel monoclonal antibodies.
• Rare disease frameworks providing orphan drug incentives and regulatory fast-tracking.
• Expanding role of patient advocacy groups in improving awareness and treatment access.

Key Challenges
• High treatment costs of biologics and IVIG.
• Delayed diagnosis due to rarity and misdiagnosis as other skin conditions.
• Limited physician expertise in emerging economies.

Latest Trends
• Growth of FcRn inhibitors (efgartigimod, nipocalimab) as pipeline candidates.
• Expansion of precision medicine approaches guided by biomarkers.
• Increased use of real-world evidence (RWE) to support reimbursement.
• Digital patient monitoring to improve adherence and outcomes.

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Competitor Analysis
Major Players
• Roche (Genentech) - Market leader with rituximab, the first FDA-approved biologic for PV.
• Novartis AG - Expanding rare autoimmune pipeline.
• Sanofi & Regeneron Pharmaceuticals - Active in dermatology and immunology biologics.
• Pfizer - Developing FcRn inhibitors for rare autoimmune diseases.
• Amryt Pharma - Focused on rare dermatology disorders.
• Argenx - Advancing efgartigimod (FcRn inhibitor) in autoimmune trials.
• Eli Lilly - Strong dermatology pipeline.
Summary: Roche dominates today with rituximab, but competition is intensifying with Argenx, Pfizer, and Sanofi advancing next-generation biologics.

Conclusion
The pemphigus vulgaris market is undergoing a paradigm shift, moving from broad immunosuppressants to targeted biologics and innovative immunotherapies. With an expected CAGR of ~7.1% (2025-2034), the outlook is promising, though affordability and delayed diagnoses remain key barriers.

Key Takeaways:
• Rituximab has set a new treatment benchmark for PV.
• North America and Europe dominate the market, while Asia-Pacific will see the fastest growth.
• The pipeline of FcRn inhibitors and next-generation biologics will reshape the competitive landscape.
• Companies focusing on rare disease expertise and payer partnerships will lead the next decade.

The coming years promise earlier diagnosis, safer biologics, and improved patient outcomes, positioning PV as a high-priority niche in autoimmune dermatology.

This report is also available in the following languages : Japanese (尋常性天疱瘡市場), Korean (천포창 시장), Chinese (寻常型天疱疮市场), French (Marché du pemphigus vulgaire), German (Pemphigus Vulgaris Markt), and Italian (Mercato del pemfigo volgare), etc.

Request for a sample of this research report at (Use Corporate Mail ID for Quick Response) @ https://exactitudeconsultancy.com/reports/71389/pemphigus-vulgaris-market#request-a-sample

Our More Reports:

Von Hippel-Lindau (VHL) Disease Market
https://exactitudeconsultancy.com/reports/71711/von-hippel-lindau-vhl-disease-market

Hereditary ATTR (hATTR) amyloidosis Market
https://exactitudeconsultancy.com/reports/71709/hereditary-attr-hattr-amyloidosis-market

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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
https://bulletin.exactitudeconsultancy.com/

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https://exactitudeconsultancy.com/

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