Nucleic Acid Therapeutics CDMO Market Growth Trends Driven by Increasing Demand for Modified Nucleic Acids Primers Probes and Oligo Services

InsightAce Analytic Pvt. Ltd. announces the release of market assessment report on "Global Nucleic Acid Therapeutics CDMO Market By Technology (Column-Based Method and Microarray-Based Method), Products (Standard Nucleic Acid, Micro-Scale Nucleic Acid, Large-Scale Nucleic Acid, Custom Nucleic Acid, Modified Nucleic Acid, Primers, Probes, Other Nucleic Acid, and Other Services), End-users (Pharmaceutical Companies, Academic Research Institute, Diagnostic Laboratories) Chemical Synthesis (Solid-Phase Oligonucleotide Synthesis, Liquid-Phase Oligonucleotide Synthesis) - By Trends, Industry Competition Analysis, Revenue and Forecast Till 2034"

According to the latest research by InsightAce Analytic, the global nucleic acid therapeutics CDMO market size valued at USD 2,540.9 Million in 2024 and it is expected to reach USD 8,688.2 Million by the year 2034, recording a promising CAGR of 13.2% during the period of 2025-2034. By region,

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Nucleic acid therapeutics have emerged as a transformative modality in the treatment of various genetic and chronic diseases, with rising disease prevalence driving increased demand for DNA- and RNA-based therapies. Developed using deoxyribonucleic acid (DNA), ribonucleic acid (RNA), or their derivatives, these therapies are witnessing expanding clinical applications, which is in turn fueling significant growth within the Contract Development and Manufacturing Organization (CDMO) sector.

To enhance capabilities in nucleic acid drug production, industry players are actively pursuing strategic initiatives such as mergers, acquisitions, collaborations, and facility expansions. A notable example is the December 2016 acquisition of GeneDesign, Inc., a leading Japanese CDMO specializing in nucleic acid therapeutics, by Ajinomoto Co., Inc. and OmniChem N.V., which strengthened the companies' positions within the nucleic acid CDMO landscape.

Market expansion is further supported by growing demand for messenger RNA (mRNA)-based therapeutics, increasing global healthcare expenditures, cost efficiencies offered by CDMO services, a rising number of regulatory approvals for nucleic acid-based drugs, and accelerated adoption of advanced nucleic acid technologies across both diagnostic and therapeutic applications.

However, the industry faces several challenges that may constrain growth, including supply chain inefficiencies, complexities in achieving targeted delivery, the need to maintain therapeutic efficacy while minimizing off-target effects, and a limited talent pool with expertise in nucleic acid manufacturing.

Regionally, North America is expected to experience the fastest growth, driven by substantial R&D investments, the emergence of innovative market participants, increased demand for nucleic acid therapies-particularly following the COVID-19 pandemic-and supportive reimbursement frameworks. The Asia-Pacific region is also projected to register strong growth, underpinned by a rising incidence of genetic diseases, a rapidly expanding biopharmaceutical sector, and ongoing advancements in medical technologies and manufacturing capabilities.

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Major key players in the nucleic acid therapeutics CDMO market are Agilent Technologies, Inc., Ajinomoto Co. Inc., Bachem Holding AG., Biospring GmbH, Corden Pharma International, Danaher Corporation, Guangzhou Ruibo Biotechnology Co., Ltd., KNC Laboratories Co., Ltd., LGC Limited, Merck KGaA, Nippon Shokubai Co., Ltd., Nitto Denko Avecia Inc, QIAGEN N.V., S.T. Pharm Co Ltd, Sumitomo Chemical Co., Ltd., Syngene International Limited, Thermo Fisher Scientific Inc., Wuxi AppTec, Yamasa Corporation, Laboratorios Farmacéuticos Rovi, S.A., Sartorius AG (BIA Separations), AGC Biologics, FUJIFILM Diosynth Biotechnologies, Hanmi Pharmaceutical, Arranta Bio (Recipharm), ST Pharm, BioCina Pty Ltd., Curia Global, Inc. and Other Prominent Players.

Key Industry Developments:
• In June 2022, Merck agreed with Agilent Technologies to develop Process Analytical Technologies (PAT). Merck and Agilent Technologies are filling a void in the downstream PAT market through this partnership. Merck expands real-time monitoring and automated process control of key process parameters (CPPs) and critical quality attributes (CQAs) to downstream processing through the combination of its bioprocess portfolio with Agilent Technologies' sophisticated analytical technologies.
• In June 2022, CordenPharma expanded its xRNA capabilities at its Caponago, Italy, plant for sterile injectables. The business claims to have invested over €10 million in a new formulation, research, and manufacturing areas for Lipid Nanoparticles (LNP). The expansion will help clients go from pre-clinical to clinical development of xRNA-based treatments (mRNA, siRNA, saRNA, microRNA, etc.), accelerating the delivery of their new medicinal solutions into clinical stages and beyond.
• In Feb 2022, Recipharm has acquired Arranta Bio. The acquisition is a cornerstone of Recipharm's strategy to provide scientifically differentiated contract development and manufacturing services for ATMPs to innovative drug developers in the Biologics market. It builds on the capabilities acquired through the recently announced GenIbet transaction and the acquisition of Vibalogics.
• In June 2021, Danaher Corporation announced that it would add protein production, plasmid DNA, and mRNA services to its bulging life sciences portfolio by acquiring Aldevron. Through the acquisition, Danaher adds contract manufacturing services.
• In August 2020, Agilent Technologies Inc. announced it would extend its advanced production facility in Frederick, Colorado, that develops and produces "oligos," which are short DNA and RNA molecules used to make nucleic acid-based therapeutics. Oligos hold the potential to be used in inventing treatments for cancer, COVID-19, cardiovascular disease, rare and infectious diseases, and other conditions. The expansion has increased the current capacity for manufacturing therapeutic oligos at the Frederick site.

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Market Segments
Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2022 to 2030 based on Technology
• Column-Based Method
• Microarray-Based Method
Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2022 to 2030 based on Products
• Standard Nucleic Acid
• Micro-Scale Nucleic Acid
• Large-Scale Nucleic Acid
• Custom Nucleic Acid
• Modified Nucleic Acid
• Primers
• Probes
• Other Nucleic Acid
• Other Services
Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2022 to 2030 based on Chemical Synthesis
• Solid-Phase Oligonucleotide Synthesis
• Liquid-Phase Oligonucleotide Synthesis
Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2022 to 2030 based on End-Users
• Pharmaceutical Companies
• Academic Research Institute
• Diagnostic Laboratories
Market Size (Value US$ Mn) & Forecasts and Trend Analyses, 2022 to 2030 based on Region
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Nucleic Acid Therapeutics CDMO market revenue (US$ Million) by Country, 2022 to 2030
• U.S.
• Canada
Europe Nucleic Acid Therapeutics CDMO market revenue (US$ Million) by Country, 2022 to 2030
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Nucleic Acid Therapeutics CDMO market revenue (US$ Million) by Country, 2022 to 2030
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Nucleic Acid Therapeutics CDMO market revenue (US$ Million) by Country, 2022 to 2030
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Nucleic Acid Therapeutics CDMO market revenue (US$ Million) by Country, 2022 to 2030
• GCC Countries
• South Africa
• Rest of Middle East & Africa

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 To receive a comprehensive analysis of the prospects for global Nucleic Acid Therapeutics CDMO market
 To receive industry overview and future trends of global Nucleic Acid Therapeutics CDMO market
 To analyse the Nucleic Acid Therapeutics CDMO market drivers and challenges
 To get information on Nucleic Acid Therapeutics CDMO market size value (US$ Mn) forecast till 2030
 To get detailed information on major Investments, Mergers & Acquisition in global Nucleic Acid Therapeutics CDMO market industry

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