Press release
Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Industry Growth Outlook: 12.5% CAGR and $8.21 Billion by 2029
Messenger Ribonucleic Acid mRNA Synthesis And Manufacturing
What Is the Long-Term Growth Forecast for the Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Market Size 2025?
In recent times, there's been a fast-paced growth in the size of the messenger ribonucleic acid (mRNA) synthesis and manufacturing market. A surge from $4.56 billion in 2024 to $5.14 billion in 2025 is expected, translating to a compound annual growth rate (CAGR) of 12.7%. Factors such as increased government funding for pandemic readiness, the early triumph of COVID-19 mRNA vaccines, a growing fascination with personalized medicine, a rising frequency of infectious diseases, as well as partnerships between biotech companies and the academic world attribute to the growth seen in the historic period.
What CAGR is Forecasted for the Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Market Through 2029?
In the upcoming years, the market for messenger ribonucleic acid (mRNA) synthesis and manufacturing is projected to experience speedy growth. This market is anticipated to escalate to a value of $8.21 billion in 2029, with a compound annual growth rate (CAGR) of 12.5%. Factors contributing to this growth during the forecast period include the broadening of therapeutic applications beyond just vaccines, advancements in technology of mRNA delivery systems, increased investments into biomanufacturing infrastructure, the rising need for swift vaccine development platforms and the support provided by regulatory authorities aimed at speeding up approvals. The forecast period also reveals certain major trends such as a move towards decentralized and modular mRNA production units, the incorporation of artificial intelligence and automation into synthesis workflows, the creation of thermostable mRNA formulations, the promising circRNA technologyalong with the rise of self-amplifying mRNA platforms.
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What Are the Critical Factors Driving Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Market Development?
The rise in infectious diseases is projected to fuel the expansion of the messenger ribonucleic acid (mRNA) synthesis and manufacturing market in future. These diseases are illnesses resulting from harmful microbes like bacteria, viruses, fungi, or parasites that can transmit ailments like malaria, either directly or indirectly. The surge in infectious diseases can be attributed to rapid urbanization, resulting in increased population density and close human contact, thereby boosting the propagation of infections. mRNA synthesis and manufacturing play a crucial role in combating infectious diseases, by facilitating the swift creation and scalable production of specifically targeted vaccines and therapeutics to induce a particular immune response. For instance, according to the World Health Organization, a Switzerland-based intergovernmental agency, in November 2023, there were approximately 249 million cases of malaria, an infectious disease, worldwide in 2022, marking an increase of 5 million cases (2%) in comparison to 2021. Consequently, the surging prevalence of infectious diseases is fostering the growth of the messenger ribonucleic acid (mRNA) synthesis and manufacturing market.
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How Does the Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Market Break Down Across Major Segments?
The messenger ribonucleic acid (mrna) synthesis and manufacturing market covered in this report is segmented -
1) By Service Type: Messenger Ribonucleic Acid (mRNA) Drug Synthesis, Messenger Ribonucleic Acid (mRNA) Vaccine Synthesis
2) By Scale Of Operation: Preclinical, Clinical, Commercial
3) By Therapeutic Area: Infectious Diseases, Oncology, Other Therapeutic Areas
4) By Application: Vaccine Production, Therapeutic Development, Drug Discovery, Other Applications
Subsegments:
1) By Messenger Ribonucleic Acid (mRNA) Drug Synthesis: Custom Messenger Ribonucleic Acid (mRNA) Synthesis, GMP-Grade Messenger Ribonucleic Acid (mRNA) Synthesis, Large-Scale Messenger Ribonucleic Acid (mRNA) Synthesis, Modified Messenger Ribonucleic Acid (mRNA) Synthesis, Capping And Tailing Services, Purification Services
2) By Messenger Ribonucleic Acid (mRNA) Vaccine Synthesis: Preclinical Messenger Ribonucleic Acid (mRNA) Vaccine Synthesis, Clinical-Grade Messenger Ribonucleic Acid (mRNA) Vaccine Synthesis, GMP-Compliant Vaccine Batch Production, Self-Amplifying Messenger Ribonucleic Acid (mRNA) Synthesis, Messenger Ribonucleic Acid (mRNA)-LNP Formulation Services For Vaccines, Stability Testing And QC Services
What Are the Major Trends Transforming the Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Industry?
Major firms in the mRNA synthesis and manufacturing market are putting their efforts into creating novel products like co-transcriptional capping platforms. These platforms aim to expedite preclinical research and mitigate regulatory challenges. Essentially, a co-transcriptional capping platform is a unique technique that seamlessly appends a shield to mRNA molecules whilst in synthesis, thereby elevating the stability, translation efficiency, and control of immunogenicity of the mRNA. For example, in May 2025, GenScript, an American life sciences research tools firm, introduced its mRNA production service resembling good manufacturing practice (GMP). This regulatory-compliant, scalable service was devised to generate high-quality, functional mRNA meant for IND-enabling preclinical investigations, which comprises of toxicology, biodistribution, and pharmacokinetics or pharmacodynamics (PK or PD) reviews. Developed under cleanroom-adherent, ISO 7-classified settings, this service utilizes exclusive co-transcriptional capping technology, and provisions the tailored mRNA within as short as seven weeks. This breakthrough serves to fill the substantial developmental void between research-level and full-scale GMP manufacturing, thus making regulatory-compliant explorations more affordable and timely for early-stage biotech and pharmaceutical enterprises, as opposed to conventional GMP production.
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Which Players Are Driving Innovation in the Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Market?
Major companies operating in the messenger ribonucleic acid (mrna) synthesis and manufacturing market are Thermo Fisher Scientific Inc., Evonik Industries AG, Moderna Inc., BioNTech SE , AGC Biologics A/S, Eurofins Scientific SE, Lonza Group AG, Catalent Inc., WuXi Biologics (Cayman) Inc., Samsung Biologics Co Ltd., GenScript Biotech Corporation, Arcturus Therapeutics Holdings Inc., New England Biolabs Inc., CureVac N.V., Abzena plc, Creative Biolabs Inc., Aldevron LLC, eTheRNA immunotherapies NV, Bio-Synthesis Inc., TriLink BioTechnologies LLC
Which Regions Are Driving Global Messenger Ribonucleic Acid (mRNA) Synthesis And Manufacturing Market Expansion?
North America was the largest region in the messenger ribonucleic acid (mRNA) synthesis and manufacturing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the messenger ribonucleic acid (mrna) synthesis and manufacturing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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