Krabbe Disease Market to Witness Promising Upswing by 2034, DelveInsight Forecasts

DelveInsight's "Krabbe Disease Market Insights, Epidemiology, and Market Forecast-2034′′ report offers an in-depth understanding of the Krabbe Disease, historical and forecasted epidemiology as well as the Krabbe Disease market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

The latest healthcare forecast report provides an in-depth analysis of Krabbe Disease, offering comprehensive insights into the Krabbe Disease revenue trends, prevalence, and treatment landscape. The report delves into key Krabbe Disease statistics, highlighting the current and projected market size, while examining the efficacy and development of emerging Krabbe Disease therapies. Additionally, we cover the landscape of Krabbe Disease clinical trials, providing an overview of ongoing and upcoming studies that are poised to shape the future of Krabbe Disease treatment. This report is an essential resource for understanding the market dynamics and the evolving therapeutic options within the Krabbe Disease space.

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Some of the key facts of the Krabbe Disease Market Report:
• The Krabbe Disease market size is anticipated to grow with a significant CAGR during the study period (2020-2034)
• In March 2024, Forge Biologics announced that the Medicines and Healthcare Products Regulatory Agency (MHRA), the healthcare regulatory body of the United Kingdom (UK), granted Innovation Passport designation to the Company's novel AAV gene therapy program, FBX-101, to enter the Innovative Licensing and Access Pathway (ILAP).
• Key Krabbe Disease Companies: Forge Biologics, Polaryx Therapeutics, and others
• Key Krabbe Disease Therapies: FBX-101, PLX-300, and others
• The Krabbe Disease market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Krabbe Disease pipeline products will significantly revolutionize the Krabbe Disease market dynamics.
• According to the National Organization for Rare Disorders (NORD, 2024), Krabbe disease affects approximately 1 in 100,000 newborns. The majority of cases-about 85-90%-present as the more severe infantile-onset form. The remaining 10-15% of individuals are diagnosed with the late-onset form of the disease, though recent findings from state newborn screening programs suggest this percentage may be higher.
• Ghabash et al. (2021) analyzed data from the KID and PHIS databases and estimated the birth incidence of Krabbe disease in the United States to be approximately 1 in 310,000 live births.
• According to Metabolic Support UK, this condition is estimated to impact roughly 1 in 100,000 individuals within the Northern European population.
• With an estimated Krabbe incidence of 1 in 310,679 births, it is projected that around 12 children born each year in the United States will be at risk of developing symptomatic Krabbe disease.

Krabbe Disease Overview
Krabbe disease is a rare, inherited disorder that affects the nervous system. It is caused by a deficiency of an enzyme called galactocerebrosidase (GALC), which is essential for the breakdown of certain fats in the body. Without this enzyme, toxic substances build up in the brain and other areas of the nervous system, leading to severe neurological damage. Symptoms usually appear in infancy and include irritability, muscle stiffness, developmental delays, and feeding difficulties. Krabbe disease is progressive and often fatal in early childhood, although later-onset forms can occur. There is no cure, but stem cell transplants may help in early stages.

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Krabbe Disease Epidemiology
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Krabbe Disease Epidemiology Segmentation:
The Krabbe Disease market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:
• Total Prevalence of Krabbe Disease
• Prevalent Cases of Krabbe Disease by severity
• Gender-specific Prevalence of Krabbe Disease
• Diagnosed Cases of Episodic and Chronic Krabbe Disease

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Krabbe Disease Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Krabbe Disease market or expected to get launched during the study period. The analysis covers Krabbe Disease market uptake by drugs, patient uptake by therapies, and sales of each drug.
Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the Krabbe Disease Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Krabbe Disease Therapies and Key Companies
• FBX-101 : Forge Biologics
• PLX-300: Polaryx Therapeutics

Discover more about therapies set to grab major Krabbe Disease market share @ Krabbe Disease Treatment Landscape
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Krabbe Disease Market Strengths
• HSCT initiated pre-symptomatically can alter the course of Krabbe disease by potentially slowing disease progression and improving outcomes.
• Newborn screening for Krabbe disease, implemented in some states, facilitates early diagnosis, enabling timely interventions that may improve treatment outcomes and quality of life for affected individuals.
• Although there is currently no effective therapy for Krabbe disease, recent gene therapy-based approaches in animal models have indicated a promising outlook for clinical treatment

Krabbe Disease Market Opportunities
• There is a lack of specific treatment options for Krabbe Disease which opens a platform of new therapies to boost the market of Krabbe Disease.
• Combinatorial therapeutic approaches using gene therapy, enzyme replacement, and substrate reduction show promise in animal models, suggesting potential advancements in future treatments for Krabbe disease

Scope of the Krabbe Disease Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
• Key Krabbe Disease Companies: Forge Biologics, Polaryx Therapeutics, and others
• Key Krabbe Disease Therapies: FBX-101, PLX-300, and others
• Krabbe Disease Therapeutic Assessment: Krabbe Disease current marketed and Krabbe Disease emerging therapies
• Krabbe Disease Market Dynamics: Krabbe Disease market drivers and Krabbe Disease market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Krabbe Disease Unmet Needs, KOL's views, Analyst's views, Krabbe Disease Market Access and Reimbursement

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About DelveInsight
DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.
It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.

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