Global Chip based Oligonucleotide Synthesis Market to Reach USD 177 Million by 2031 at 23.6% CAGR Driven by Thermo Fisher and Twist Bioscience

The global Chip-based Oligonucleotide Synthesis market is accelerating into a new phase of growth, driven by high-throughput DNA and RNA production for next-generation sequencing, gene editing, synthetic biology, and data storage. According to the recent report from QYResearch, the market is projected to grow from US$ 41 million in 2024 to US$ 177 million by 2031, achieving a compound annual growth rate of 23.6% between 2025 and 2031. Chip-based platforms, which leverage microarray and silicon technology, enable parallel synthesis of thousands to millions of oligonucleotides, offering unmatched speed, accuracy, and scalability for industrial and academic applications.

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Leading Companies
Thermo Fisher
GenScript
LC Sciences
Twist Bioscience
Agilent Technologies
Evonetix
Dynegene Technologies
LC-Bio Technologies
Atantares
BGI Genomics

Applications
Scientific Research
Others

Classification by Technology
Photochemical Method
Electrochemical Method
Inkjet Printing Method

Latest Data & Market Outlook
• Global market value: US$ 41 million in 2024, forecast to reach US$ 177 million in 2031
• CAGR: 23.6% during 2025-2031
• Regional performance: North America leads in 2024, while Asia-Pacific is forecast to show the highest CAGR, with strong contributions from China, Japan, and South Korea
• Top players: Leading suppliers account for the majority of global revenue, with Thermo Fisher ranking first in 2024
• Market coverage: Historical data 2020-2024, forecasts 2025-2031, segmented by type, application, and geography
• Industry chain: Comprehensive analysis of upstream, midstream, and downstream distribution, with a focus on cost drivers and unmet demand

Recent Developments in 2024-2025
• Twist Bioscience launched Multiplexed Gene Fragments in 2024 and a high-throughput UDI adapter system in 2025. In May 2025, it spun off its DNA data storage division as Atlas Data Storage, with US$155 million in financing.
• Agilent Technologies enhanced its SurePrint Oligo Library Synthesis platform, offering long oligonucleotides up to ~230 nucleotides with HiFi quality and continuous 24/7 production capacity.
• Evonetix advanced its benchtop DNA synthesis chip, integrating thermal control to produce accurate, gene-length DNA directly in laboratories.
• Dynegene Technologies showcased ultra-long complex oligonucleotide synthesis capabilities in 2025, signaling Asia-Pacific's growing role in high-end DNA manufacturing.
• Thermo Fisher continued to update its Affymetrix Axiom genotyping arrays, supporting up to 200,000 markers per array, directly linked to chip-based oligo manufacturing.

Five Representative Products
Twist Bioscience - Oligo Pools
• Length range: 20-300 nucleotides
• Capacity: Over 1 million unique sequences per pool
• Error rate: Approximately 1 in 3000
• Use cases: CRISPR libraries, protein mutagenesis, target enrichment
Agilent Technologies - SurePrint Oligo Libraries (HiFi Pools)
• Length: Up to ~230 nucleotides
• High-fidelity chemistry with tight representation
• Applications: Gene assembly, protein design, large-scale CRISPR screening
LC Sciences - OligoMix®
• Scale: Thousands to tens of thousands of oligonucleotides per pool
• Length: Up to 150 nucleotides, with longer lengths available on request
• Applications: Barcode libraries, CRISPR gRNA design, capture probe generation
Thermo Fisher - Axiom Custom Genotyping Arrays
• Throughput: 96 or 384 arrays per plate
• Marker density: 90,000 to 200,000 per array
• Applications: Agrigenomics, human genetics, biomarker discovery
Dynegene Technologies - UCOS Oligo Libraries
• Focus: Ultra-long DNA synthesis and pooled oligonucleotide libraries
• Application: Gene assembly, antibody discovery, de novo genome synthesis

Verified Downstream Customers
Microsoft
Ginkgo Bioworks
Element Biosciences
Absci
xFOREST Therapeutics
Curio Genomics
Admera Health
Sampled
Western Digital
bitBiome
C2i Genomics
Astellas
MBC BioLabs

Market Trends 2025
Scaling Uniformity and Accuracy
Modern chip-based platforms now deliver oligo pools with hundreds of thousands to millions of unique sequences, maintaining high uniformity. Twist Bioscience reports that over 90% of sequences fall within 2.5× of the mean abundance, reducing dropout rates and improving experimental reliability. This directly benefits CRISPR screening and protein mutagenesis campaigns.

Longer Oligos and Multiplexed Fragments
Agilent and Twist have extended routine synthesis lengths to 230-300 nucleotides. Twist has also introduced multiplexed gene fragments up to 500 base pairs, enabling direct cloning and reducing downstream assembly steps. These advancements shorten design-to-validation timelines in both research and commercial applications.

DNA Data Storage Commercialization
The field has entered a commercialization phase. Twist Bioscience's spin-off, Atlas Data Storage, is now dedicated to developing DNA as a data medium, with significant financial backing. Microsoft and Western Digital continue to invest in DNA storage research, indicating that chip-based oligo synthesis will play a foundational role in scaling this new digital archive technology.

Benchtop DNA Synthesis Emergence
Companies such as Evonetix are pioneering benchtop DNA writing systems. By integrating thermal control on semiconductor chips, these platforms aim to decentralize synthesis, allowing laboratories to generate DNA constructs without outsourcing. This trend may reshape supply chains by offering localized, on-demand synthesis.

Integration with Sequencing Workflows
Chip-based synthesis is now tightly coupled with next-generation sequencing platforms. Twist has expanded collaborations with Element Biosciences, ensuring customers can seamlessly move from oligo pools to sequencing data. Service providers such as Sampled and Admera Health have adopted integrated workflows, lowering barriers for new adopters.

Sustainability and Transparency
Customers are beginning to request environmental accountability. Twist Bioscience has published sustainability data, including the carbon footprint of oligo production. As volumes grow, cost transparency and environmental metrics are becoming part of procurement processes, adding a new dimension to competition.

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Therapeutic Pipeline Expansion
The boom in oligonucleotide-based therapeutics (ASOs, siRNAs, aptamers) continues to pull demand for chip-based oligos. While GMP production is distinct, early-stage discovery requires vast, accurate oligo libraries for validation and screening. This alignment of preclinical research with chip-based technologies is expanding the total addressable market.

Conclusion
The chip-based oligonucleotide synthesis market is entering a high-growth era characterized by technical innovation, strategic partnerships, and new application domains such as DNA data storage and benchtop gene synthesis. With a forecast CAGR of 23.6% through 2031, leading players like Thermo Fisher, Twist Bioscience, Agilent, and Evonetix are redefining the landscape with scalable, high-accuracy platforms. As downstream customers including Microsoft, Ginkgo Bioworks, and Element Biosciences continue to adopt these solutions, the sector is poised to become a cornerstone of biotechnology, digital storage, and precision medicine.
Chapter Outline:

Chapter 1: Introduces the report scope of the report, executive summary of different market segments (by region, product type, application, etc), including the market size of each market segment, future development potential, and so on. It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter 2: key insights, key emerging trends, etc.
Chapter 3: Manufacturers competitive analysis, detailed analysis of the product manufacturers competitive landscape, price, sales and revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 4: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product sales, revenue, price, gross margin, product introduction, recent development, etc.
Chapter 5 & 6: Sales, revenue of the product in regional level and country level. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and market size of each country in the world.
Chapter 7: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 8: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 9: Analysis of industrial chain, including the upstream and downstream of the industry.
Chapter 10: The main points and conclusions of the report.

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