Gastric Cancer Treatment Market Insights | Drivers, Challenges, and Innovations | DataM Intelligence

Gastric cancer, also known as stomach cancer, refers to a type of cancer that begins in the cells lining the stomach. It is one of the most common and deadly forms of cancer worldwide, particularly prevalent in East Asia, Europe, and parts of South America. Gastric cancer can develop in any part of the stomach and may spread to other organs, such as the esophagus, pancreas, liver, and lymph nodes.
According to a report by DataM Intelligence, The Global Gastric Cancer Treatment Market size reached US$ 5.82 billion in 2024 and is expected to reach US$ 14.66 billion by 2033, growing at a CAGR of 10.9% during the forecast period 2025-2033.

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Key Highlights from the Report:
➤ Global market value reached approximately US$ 5.82 billion in 2024 and is forecasted to reach US$ 14.66 billion by 2033, growing at a CAGR of 10.9%.
➤ Rising advancements in targeted therapies, including HER2-targeted and CLDN18.2-targeted treatments, are major growth drivers in the market.
➤ Astellas Pharma's VYLOY (zolbetuximab-clzb) received approval in October 2024 for use in combination chemotherapy for CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma.
➤ BeiGene's TEVIMBRA (tislelizumab-jsgr) gained FDA approval in December 2024 for first-line treatment of unresectable or metastatic HER2-negative gastric cancer in PD-L1 ≥ 1 patients.
➤ Nearly 1.02 million prevalent gastric cancer cases were estimated worldwide in 2024, with the highest prevalence in the Asia-Pacific region.
➤ Chemotherapy remains the dominant treatment type in market revenue, while immunotherapy and targeted therapies continue to expand the market segment.

Market Segmentation:
By Cancer Type:
The gastric cancer treatment market is segmented based on various cancer types, reflecting differences in tumor location, biology, and treatment response. Non-Cardia (Distal) Stomach Cancer is the most common type, originating in the lower portion of the stomach, often associated with Helicobacter pylori infection and dietary factors. Proximal Stomach Cancer, occurring near the esophagus, is increasing in prevalence due to lifestyle factors such as obesity and GERD. Diffuse Stomach Cancer is an aggressive form with widespread stomach involvement, whereas Lymphomas arise from immune tissue within the stomach. Gastrointestinal Stromal Tumors (GISTs) and Carcinoid Tumors are rarer subtypes, requiring specialized therapies. Adenocarcinoma remains the predominant type, accounting for the majority of cases, and the "Others" category includes rare or mixed tumor types that require tailored interventions.

By Treatment Type:
The chemotherapy segment is expected to dominate the gastric cancer treatment market with the highest market share
Chemotherapy is frequently used as the primary treatment in advanced gastric cancer, often in combination with targeted therapies or immunotherapy. In cases where surgery is not possible, chemotherapy serves as a crucial palliative treatment to control symptoms, slow the disease's progression, and improve survival rates. For instance, FOLFOX (a combination of 5-fluorouracil (5-FU), oxaliplatin, and leucovorin) is a standard chemotherapy regimen used in gastric cancer. This regimen is particularly effective for advanced gastric cancer and has been widely adopted.
Chemotherapy is frequently combined with targeted therapies like trastuzumab, ramucirumab, and nivolumab to enhance efficacy, especially in advanced or metastatic gastric cancer. These combination regimens have become the standard of care in many treatment protocols. The growing trend of combining chemotherapy with newer therapies has expanded its market dominance, as it remains the central component of first-line and second-line treatment regimens in both HER2-positive and HER2-negative gastric cancers.

By Route of Administration:
The route of administration plays a key role in patient compliance and treatment effectiveness. Injectable therapies, primarily intravenous, are the dominant route for chemotherapy, immunotherapy, and targeted biologics due to their controlled dosing and efficacy. Oral therapies are increasingly preferred for certain targeted drugs and tyrosine kinase inhibitors, offering convenience, reduced hospital visits, and improved adherence, particularly in long-term treatment regimens. The availability of multiple administration routes allows personalized treatment plans, optimizing outcomes and patient quality of life.

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Regional Insights:
North America:
North America has been a leader in adopting targeted therapies and immunotherapies, which are increasingly used to treat gastric cancer. The region's healthcare system supports the use of expensive, but highly effective, biologics and immunotherapy drugs that target specific proteins or immune checkpoints involved in cancer progression.

Latin America:
Latin America shows steady demand for gastric cancer treatments, with Brazil and Mexico leading due to rising cancer incidence and expanding healthcare access. Limited reimbursement policies and disparities in cancer care infrastructure challenge growth. However, government initiatives to improve oncology care and increased awareness campaigns are creating opportunities for advanced therapies.

Europe:
Germany, France, and the UK dominate the European gastric cancer treatment market, driven by advanced healthcare systems, strong clinical research, and robust reimbursement frameworks. Europe remains a key hub for clinical trials, particularly in immunotherapy and targeted therapies.

Asia Pacific:
China, Japan, and India account for the highest burden of gastric cancer worldwide, particularly due to dietary habits and Helicobacter pylori prevalence. Japan remains a leader in gastric cancer research and early diagnosis, while China invests heavily in clinical trials and biologics. Rapid healthcare expansion in India also supports strong market growth.

Middle East and Africa:
The UAE and Saudi Arabia represent the leading markets in the Middle East, with increasing adoption of modern oncology treatments. In Africa, limited diagnostic capabilities and healthcare inequalities hinder growth, though South Africa is seeing gradual progress in cancer therapy access.

Market Drivers:
One of the most notable advancements in gastric cancer treatment has been the development of HER2-targeted therapies. HER2 (human epidermal growth factor receptor 2) is a protein overexpressed in some gastric cancer cells, leading to uncontrolled cell growth. Trastuzumab (Herceptin), a monoclonal antibody targeting HER2, has been a groundbreaking treatment for HER2-positive gastric cancer. The success of this treatment has led to its widespread use in combination with chemotherapy for advanced gastric cancer.

Market Restraints:
Despite the significant advancements in gastric cancer treatment, side effects and safety concerns continue to pose major challenges in the management of the disease. The adverse effects associated with both traditional and targeted therapies often deter patients from adhering to prescribed regimens, impact their quality of life, and complicate treatment regimens. These concerns, in turn, hinder the widespread adoption and growth of the gastric cancer treatment market.

Market Opportunities
The gastric cancer treatment market presents significant opportunities driven by rising prevalence rates, particularly in Asia-Pacific, where the disease burden is highest. Advances in personalized medicine, including targeted therapies such as HER2 and CLDN18.2 inhibitors, are expanding treatment options with improved efficacy. Growing adoption of immunotherapies and combination therapies is expected to accelerate market growth, supported by ongoing clinical trials and regulatory approvals.

Reasons to Buy the Report
• Pipeline & Innovations: Reviews ongoing clinical trials, product pipelines, and forecasts upcoming advancements in medical devices and pharmaceuticals.
• Product Performance & Market Positioning: Analyze product performance, market positioning, and growth potential to optimize strategies.
• Real-World Evidence: Integrates patient feedback and data into product development for improved outcomes.
• Physician Preferences & Health System Impact: Examines healthcare provider behaviors and the impact of health system mergers on adoption strategies.
• Market Updates & Industry Changes: Covers recent regulatory changes, new policies, and emerging technologies.

Frequently Asked Questions (FAQs)
o How big is the Gastric Cancer Treatment Market ?
o Who are the key players in the Gastric Cancer Treatment Market ?
o What are the latest treatment options available for gastric cancer?
o Which regions have the highest prevalence of gastric cancer?
o How is the market for targeted and immunotherapy treatments evolving?

Company Insights:
• Merck & Co.,Inc.
• Eli Lilly and Company,
• Genentech USA, Inc.
• Pfizer Inc.
• Astellas Pharma Inc.
• Bristol-Myers Squibb Company
• Blueprint Medicines Corporation
• Daiichi Sankyo, Inc.
• BeiGene, Ltd.
• Ipsen Biopharmaceuticals Inc.
• Taiho Oncology, Inc.
• Deciphera Pharmaceuticals, LLC

Recent Developments:
In October 2024, the U.S. Food and Drug Administration (FDA) approved Astellas' Vyloy (zolbetuximab), a monoclonal antibody targeting CLDN18.2, for use in combination with chemotherapy to treat a specific type of gastric cancer located at the gastroesophageal junction. This approval marks the first targeted treatment for this cancer subtype in the U.S., following earlier approvals in Japan and the UK. Roche's companion diagnostic test for identifying eligible patients also received FDA approval.
A groundbreaking clinical trial presented at the 2025 American Society of Clinical Oncology (ASCO) conference demonstrated that CAR T-cell therapy significantly extended survival in patients with advanced gastric or gastroesophageal junction cancers. The therapy, which involves genetically modifying a patient's own T-cells to better recognize and destroy cancer cells, improved overall survival by approximately 40% compared to standard treatments. This milestone suggests a potential new avenue for treating solid tumors, which have historically been challenging to address with immunotherapy.

Conclusion:
The gastric cancer treatment market is poised for substantial growth over the coming years, driven by rising prevalence, increasing awareness, and rapid advancements in targeted therapies and immunotherapies. Strong demand in Asia-Pacific, particularly in Japan and China, combined with expanding healthcare infrastructure in emerging regions, offers significant growth potential. Innovations such as CAR T-cell therapy, CLDN18.2-targeted drugs, and personalized treatment approaches are reshaping the therapeutic landscape, improving patient outcomes, and expanding market opportunities.

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