Atopic Dermatitis Clinical, Companies, Therapeutic Assessment, Therapies, Treatment Algorithm, Pipeline Analysis | Vanda Pharmaceuticals, TechnoDerma Medicines, Asana BioSciences, Artax Biopharma, Corvus Pharmaceuticals, Yuhan, BioVersys, Rubedo Life Scie

Atopic Dermatitis Pipeline constitutes 100+ key companies continuously working towards developing 120+ Atopic Dermatitis treatment therapies, analyzes DelveInsight.

Atopic Dermatitis Overview:

Atopic Dermatitis (AD), commonly known as eczema, is a long-term inflammatory skin disorder that often begins in early childhood but can develop at any age and may persist or recur throughout life. The term "dermatitis" stems from "derm" (skin) and "itis" (inflammation), indicating skin inflammation. AD is marked by symptoms such as itching, redness, and rashes, often caused by a combination of genetic predisposition, an overreactive immune system, environmental irritants, allergens, and infections.

Nearly half of individuals with moderate-to-severe eczema also suffer from other allergic conditions like asthma, hay fever (allergic rhinitis), or food allergies. It is the most prevalent chronic skin disorder in children. The hallmark symptom is dry, itchy skin, which can worsen into red, inflamed rashes during flare-ups. Various internal and external factors may trigger these flares, leading to inflammation, increased blood flow, and intense itching. This sets off a vicious itch-scratch cycle, potentially resulting in skin infections, dryness, discoloration, and skin thickening (lichenification) from repeated scratching.

The pathophysiology of AD is multifaceted, involving barrier defects, immune system dysregulation, IgE-mediated hypersensitivity, and environmental triggers. Filaggrin gene mutations are associated with more severe AD, as they can increase water loss through the skin, raise skin pH, and cause dehydration. Other genetic variants may also impair skin barrier function, contributing to disease development. A skewed balance of Th2 and Th1 cytokines disrupts normal immune responses and enhances IgE production, both of which are believed to contribute to AD. On a microscopic level, spongiosis-fluid buildup between skin cells-facilitates the infiltration of inflammatory substances. Various dendritic cell types, including Langerhans cells, inflammatory dendritic epidermal cells, and plasmacytoid dendritic cells, are critical to disease progression.

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"Atopic Dermatitis Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Atopic Dermatitis Therapeutics Market.

Key Takeaways from the Atopic Dermatitis Pipeline Report

DelveInsight's Atopic Dermatitis pipeline report depicts a robust space with 100+ active players working to develop 120+ pipeline therapies for Atopic Dermatitis treatment.
The FDA has extended the PDUFA review deadline to September 19, 2025, for the 0.75% ruxolitinib cream supplement aimed at children aged 2-11 with mild-to-moderate AD. The extension is to allow evaluation of updated chemistry, manufacturing, and control (CMC) data.
Approved by the FDA in December 2024 for individuals aged 12 and above with moderate-to-severe AD whose disease isn't sufficiently controlled with topical corticosteroids or calcineurin inhibitors. Nemluvio targets IL‐31 receptor A to address itch and inflammation.
Approved in September 2024 for patients aged 12 + with moderate-to-severe AD, Ebglyss is a once-monthly injectable biologic that neutralizes IL‐13. Treatment proved effective in clinical trials involving over 1,000 patients.
Key Atopic Dermatitis companies such as Vanda Pharmaceuticals, TechnoDerma Medicines, Asana BioSciences, Artax Biopharma, Corvus Pharmaceuticals, Yuhan, BioVersys, Rubedo Life Sciences, Innocare Pharma, Apogee Therapeutics, Celldex Therapeutics, Aclaris Therapeutics, Astria Therapeutics, and others are evaluating new drugs for Atopic Dermatitis to improve the treatment landscape.
Promising Atopic Dermatitis pipeline therapies in various stages of development include ICP-332, APG777, Barzolvolimab, ATI-2138, STAR-0310, and others.

Atopic Dermatitis Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Atopic Dermatitis Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Atopic Dermatitis treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Atopic Dermatitis market.

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Atopic Dermatitis Emerging Drugs

ICP-332 - InnoCare Pharma

ICP-332 is a highly selective and potent inhibitor of TYK2, currently being developed to treat a range of T-cell-mediated autoimmune conditions such as atopic dermatitis (AD), vitiligo, and inflammatory bowel disease. TYK2, a non-receptor tyrosine kinase within the JAK family, plays a critical role in the JAK-STAT signaling pathway, which is key to the development of various inflammatory diseases. With promising therapeutic potential across multiple indications, ICP-332 is currently undergoing Phase III clinical trials for the treatment of atopic dermatitis.
APG777 - Apogee Therapeutics

APG777 is an innovative, long-acting monoclonal antibody administered subcutaneously, designed to target interleukin-13 (IL-13) for the treatment of atopic dermatitis. In preclinical comparisons, APG777 demonstrated similar or superior efficacy to lebrikizumab in blocking IL-13 signaling. Data from a Phase I study over 12 months revealed an extended half-life of 77 days, along with a strong safety profile and favorable pharmacodynamics. A single dose provided near-complete pSTAT6 inhibition and durable TARC suppression for up to a year. The drug is currently in Phase II clinical trials for AD.

Atopic Dermatitis Companies

Over 100 prominent companies are actively engaged in developing therapies for Atopic Dermatitis. Among them, InnoCare Pharma is one of the companies with a drug candidate that has reached the most advanced stage of development-Phase III clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Atopic Dermatitis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Atopic Dermatitis Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Atopic Dermatitis Pipeline Therapeutic Assessment
• Atopic Dermatitis Assessment by Product Type
• Atopic Dermatitis By Stage
• Atopic Dermatitis Assessment by Route of Administration
• Atopic Dermatitis Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Atopic Dermatitis Current Treatment Patterns
4. Atopic Dermatitis - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Atopic Dermatitis Late-Stage Products (Phase-III)
7. Atopic Dermatitis Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Atopic Dermatitis Discontinued Products
13. Atopic Dermatitis Product Profiles
14. Atopic Dermatitis Key Companies
15. Atopic Dermatitis Key Products
16. Dormant and Discontinued Products
17. Atopic Dermatitis Unmet Needs
18. Atopic Dermatitis Future Perspectives
19. Atopic Dermatitis Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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