Advanced Merkel Cell Carcinoma Pipeline Outlook Report 2025: Key 20+ Companies and Breakthrough Therapies Shaping the Future Landscape

DelveInsight's, "Advanced Merkel cell carcinoma Pipeline Insight" report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Advanced Merkel cell carcinoma pipeline landscape. It covers the Advanced Merkel Cell Carcinoma pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Advanced Merkel Cell Carcinoma pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Advanced Merkel Cell Carcinoma Pipeline Report

* In July 2025, Ocellaris Pharma Inc . announced a phase 1b/2a Two-Part, Open-Label, Multicenter Study to Evaluate the Safety and Pharmacokinetics of OC-001 as Monotherapy and in Combination With an Anti-PD-1/Anti-PD-L1 Antibody in Patients With Selected Locally Advanced or Metastatic Cancers.
* In July 2025, Medicenna Therapeutics Inc . conducted a Phase 1/2 study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in patients with advanced solid tumors.
* In July 2025, Marengo Therapeutics Inc. organized a phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent administered intravenously in participants with advanced solid tumors that are antigen-rich.
* DelveInsight's Advanced Merkel Cell Carcinoma Pipeline report depicts a robust space with 20+ active players working to develop 20+ pipeline therapies for Advanced Merkel Cell Carcinoma treatment.
* The leading Advanced Merkel Cell Carcinoma Companies such as Xencor, Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis, Inc., Checkpoint Therapeutics, Inc. , and others.
* Promising Advanced Merkel Cell Carcinoma Therapies such as Avelumab, BT-001, GI-101, Pembrolizumab (KEYTRUDA Registered ), Lenvatinib, OC-001, and others.

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Advanced Merkel cell carcinoma Emerging Drugs Profile

* Tidutamab: Xencor, Inc.

Tidutamab (previously XmAb18087) is a bispecific antibody that engages the immune system against tumors by binding to somatostatin receptor 2 (SSTR2) and CD3. Xencor's XmAb Registered Bispecific Fc Domain serves as the scaffold for these two antigen binding domains and confers long circulating half-life, stability and ease of manufacture on tidutamab. Engagement of CD3 by tidutamab activates T cells for highly potent and targeted killing of SSTR2-expressing tumor cells.

* Cabozantinib: Exelixis

In the U.S., CABOMETYX tablets are approved for the treatment of patients with advanced renal cell carcinoma (RCC); for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib; for patients with advanced RCC as a first-line treatment in combination with nivolumab; and for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy and who are radioactive iodine-refractory or ineligible. CABOMETYX tablets have also received regulatory approvals in the European Union and additional countries and regions worldwide. In 2016, Exelixis granted Ipsen Pharma SAS exclusive rights for the commercialization and further clinical development of cabozantinib outside of the U.S. and Japan. In 2017, Exelixis granted exclusive rights to Takeda Pharmaceutical Company Limited for the commercialization and further clinical development of cabozantinib for all future indications in Japan. Exelixis holds the exclusive rights to develop and commercialize cabozantinib in the U.S.Currently, the drug is in Phase II stage of Clinical trial evaluation for the treatment of Advanced Merkel cell carcinoma.

The Advanced Merkel Cell Carcinoma pipeline report provides insights into

* The report provides detailed insights about companies that are developing therapies for the treatment of Advanced Merkel Cell Carcinoma with aggregate therapies developed by each company for the same.
* It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Advanced Merkel Cell Carcinoma Treatment.
* Advanced Merkel Cell Carcinoma Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
* Advanced Merkel Cell Carcinoma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
* Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Advanced Merkel Cell Carcinoma market.

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Advanced Merkel Cell Carcinoma Companies

Xencor, Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis, Inc., Checkpoint Therapeutics, Inc., and others.

Advanced Merkel cell carcinoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration

* Oral
* Parenteral
* intravenous
* Subcutaneous
* Topical.

Advanced Merkel Cell Carcinoma Products have been categorized under various Molecule types such as

* Monoclonal Antibody
* Peptides
* Polymer
* Small molecule
* Gene therapy

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Scope of the Advanced Merkel Cell Carcinoma Pipeline Report

* Coverage- Global
* Advanced Merkel Cell Carcinoma Companies- Xencor, Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis, Inc., Checkpoint Therapeutics, Inc., and others.
* Advanced Merkel Cell Carcinoma Therapies- Avelumab, BT-001, GI-101, Pembrolizumab (KEYTRUDA Registered ), Lenvatinib, OC-001 , and others.
* Advanced Merkel Cell Carcinoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* Advanced Merkel Cell Carcinoma Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Content

* Introduction
* Executive Summary
* Advanced Merkel cell carcinoma: Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Advanced Merkel cell carcinoma - DelveInsight's Analytical Perspective
* Mid Stage Products (Phase II)
* Cabozantinib: Exelixis
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I)
* IFx-Hu2.0: Morphogenesis
* Drug profiles in the detailed report.....
* Inactive Products
* Advanced Merkel cell carcinoma Key Companies
* Advanced Merkel cell carcinoma Key Products
* Advanced Merkel cell carcinoma- Unmet Needs
* Advanced Merkel cell carcinoma- Market Drivers and Barriers
* Advanced Merkel cell carcinoma- Future Perspectives and Conclusion
* Advanced Merkel cell carcinoma Analyst Views
* Advanced Merkel cell carcinoma Key Companies
* Appendix

About Us

DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.

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