Press release
Therapeutic Hypothermia Systems Market Set for Robust 5.7% CAGR Rise - Persistence Market Research Forecasts US$ 482.43 Mn by 2032
Therapeutic hypothermia-also referred to as targeted temperature management or induced hypothermia-has emerged as a critical intervention in the management of patients suffering from neurological injury due to cardiac arrest, ischemic stroke, or neonatal hypoxic-ischemic encephalopathy (HIE). It involves the controlled reduction of a patient's core body temperature to improve neurological outcomes and reduce tissue damage. As advancements in minimally invasive and AI-enabled temperature control devices accelerate, the global therapeutic hypothermia systems market is set to witness significant growth.According to Persistence Market Research, the market size is projected to reach US$ 326.41 Mn in 2025 and expand to US$ 482.43 Mn by 2032, reflecting a CAGR of 5.7%. This upward trend is driven by the increasing incidence of cardiovascular diseases such as myocardial infarction (MI) and cardiac arrest, as well as the growing number of surgical procedures globally.
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✅ Market Overview and Growth Landscape
The therapeutic hypothermia systems market is experiencing a steady rise, driven by growing awareness of neuroprotective interventions, higher survival expectations in post-cardiac arrest patients, and expanded applications in neonatology and surgery. In 2025, cooling devices are anticipated to dominate the market with a 60% share, mainly due to their ease of use, affordability, and compatibility with a wide range of clinical environments.
North America is projected to remain the leading geographical region, accounting for approximately 45% of the global market share in 2025. This dominance is attributed to the region's advanced healthcare infrastructure, high prevalence of neurological and cardiovascular diseases, and strong presence of market-leading companies. The neurology segment is expected to hold the largest share of the market by indication, driven by the high prevalence of ischemic strokes, traumatic brain injuries, and HIE cases.
✅Key Highlights from the Report:
➤ Cooling devices are expected to hold around 60% of the market share in 2025.
➤ The global market is forecasted to grow at a 5.7% CAGR from 2025 to 2032.
➤ The neurology segment will lead with approximately 45% market share in 2025.
➤ Cardiology is expected to be the fastest-growing application segment through 2032.
➤ North America will dominate with a 45% market share in 2025.
➤ Emerging markets like India and China offer strong future growth potential.
✅ Market Segmentation
By Product Type, the market is segmented into cooling devices and cooling catheters. Cooling devices-such as surface cooling blankets, head caps, and gel-based systems-dominate due to their non-invasive nature and cost-efficiency. These devices are widely used in ICUs and emergency settings due to their compatibility with sterile environments and ease of application. For instance, India's MiraCradle, a power-free cooling cradle, is successfully being used in over 125 hospitals to treat neonatal HIE effectively.
Cooling catheters are projected to be the fastest-growing subsegment. These devices are inserted into central veins and connected to external temperature control units, providing high precision in temperature management. They are gaining prominence in critical care settings, particularly for patients recovering from out-of-hospital cardiac arrests and major surgeries requiring stringent temperature control protocols.
By indication, the neurology segment is projected to dominate the market by 2025, accounting for 45% of the total market share. Increasing cases of ischemic stroke, brain trauma, and neonatal HIE are key drivers. Clinical trials have validated the effectiveness of TH in reducing neuron death and improving neurological outcomes. Meanwhile, the cardiology segment is poised to experience the highest growth due to rising cardiac arrest cases globally and the proven benefits of TH in improving survival rates post-cardiac arrest.
✅Regional Insights
North America leads the global market, driven by its advanced medical infrastructure, strong healthcare funding, and the high prevalence of cardiac arrests and strokes. Over 795,000 strokes and 356,000 out-of-hospital cardiac arrests occur annually in the U.S., pushing the demand for effective temperature management technologies.
Asia Pacific is emerging as a lucrative market due to increasing birth rates, rising cases of neonatal HIE, and improving healthcare infrastructure. India's REVIVE system and China's rapid expansion of tertiary hospitals underscore the growing adoption of advanced TH technologies in the region. These developments are enabling more affordable and accessible solutions for underserved populations.
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✅Market Drivers
One of the primary market drivers is the rising number of surgical procedures globally, which now exceed 310 million annually. With more than 50 million surgeries conducted in the U.S. and Europe combined, maintaining normothermia during and after surgery has become a clinical priority. Advanced TH systems with closed-loop feedback and real-time monitoring ensure precise temperature control, significantly improving patient outcomes.
The increasing incidence of cardiovascular and neurological conditions is another major growth factor. TH has demonstrated improved survival and neuro-recovery in patients who suffer from cardiac arrest or stroke, leading to its integration into standard emergency care protocols across hospitals worldwide. Innovations in AI-powered cooling systems are enhancing treatment accuracy and expanding their applicability across diverse clinical settings.
✅Market Restraints
Despite its potential, the therapeutic hypothermia systems market faces several challenges. One major restraint is the high cost of implementation. Advanced servo-controlled systems, necessary for precise temperature regulation, demand significant investment in equipment, maintenance, and staff training. This makes them less accessible in resource-limited regions.
Additionally, side effects and complications such as shivering, electrolyte imbalance, skin injuries, and infection risks deter wider adoption. Up to 67% of TH-treated patients may experience infections, including pneumonia and bloodstream infections. These clinical concerns, combined with the logistical and financial challenges of implementing TH protocols, particularly in low-resource settings, can limit market expansion.
✅Market Opportunities
Emerging markets, especially in Asia, Africa, and Latin America, offer tremendous growth potential due to rising birth rates and increasing cases of neonatal HIE. In LMICs, over 90% of global neonatal deaths occur, highlighting the urgent need for accessible and cost-effective interventions. Low-cost TH devices like ice packs and phase-change material mattresses are increasingly being adapted for use in these regions.
Public-private partnerships and support from international NGOs are further facilitating this shift by funding infrastructure development, offering equipment subsidies, and training healthcare workers. Collaborative initiatives like the Global South Alliance are working to tailor TH protocols for low-resource environments, thereby addressing the unique clinical and infrastructural needs of these regions.
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✔ Gain detailed insights into a fast-evolving market with projected growth through 2032
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✔ Identify key market restraints and emerging opportunities for strategic expansion
✔ Access competitive intelligence on major players and technological innovations
✔ Leverage real-world market data, trends, and forecast analysis validated by Persistence Market Research
✅ Company Insights
The competitive landscape of the therapeutic hypothermia systems market is shaped by continuous innovation, strategic partnerships, and increasing R&D investment. Key players include:
✦ Asahi Kasei Corporation
✦ Audax Management Company, LLC.
✦ Becton, Dickinson and Company
✦ EM-MED Sp. z o.o. Sp. K.
✦ Gentherm Incorporated
✦ International Biomedical Ltd.
✦ Phoenix Medical Systems Pvt. Ltd.
✦ Shenzhen Comen Medical Instruments Co., Ltd.
✦ Stryker Corporation
✦ Terumo Corporation
✅ Recent Developments:
✦ In May 2025, TEQCool AB unveiled a non-invasive intranasal brain cooling system, aiming to expand its application across broader neurological disorders and metabolic management.
✦ In January 2024, SourceMark partnered with Gentherm Medical to distribute the Gelli-Roll, a reusable gel-based warming and cooling pad, across the U.S. to enhance temperature control in critical care.
✅ Final Thoughts
The global therapeutic hypothermia systems market is on a growth trajectory, powered by increasing clinical evidence supporting the efficacy of temperature management in neurological and cardiac care. As healthcare systems evolve and focus more on quality outcomes and patient recovery, the adoption of precision temperature control solutions is set to rise. While cost and accessibility remain barriers in certain regions, innovations in low-cost devices and public-private collaborations are paving the way for widespread deployment-especially in neonatal care and post-cardiac arrest recovery. The future of the therapeutic hypothermia systems market is promising, particularly for companies willing to innovate and invest in emerging markets.
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At Persistence Market Research, we specialize in creating research studies that serve as strategic tools for driving business growth. Established as a proprietary firm in 2012, we have evolved into a registered company in England and Wales in 2023 under the name Persistence Research & Consultancy Services Ltd. With a solid foundation, we have completed over 3600 custom and syndicate market research projects, and delivered more than 2700 projects for other leading market research companies' clients.
Our approach combines traditional market research methods with modern tools to offer comprehensive research solutions. With a decade of experience, we pride ourselves on deriving actionable insights from data to help businesses stay ahead of the competition. Our client base spans multinational corporations, leading consulting firms, investment funds, and government departments. A significant portion of our sales comes from repeat clients, a testament to the value and trust we've built over the years.
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