Idiopathic Hypersomnia Treatment Market Propelled by Rising Sleep Disorder Diagnosis and Breakthrough CNS Therapies | Jazz Pharmaceuticals plc, Harmony Biosciences Holdings, Inc., AVADEL PHARMACEUTICALS PLC

Global idiopathic hypersomnia treatment market reached USD 1.5 Billion in 2024 and is expected to reach US$ 2.8 Billion by 2031, growing at a CAGR of 9% during the forecast period 2024-2031.

Idiopathic Hypersomnia Treatment Market Report by DataM Intelligence offers a detailed assessment of the global pharmaceutical and healthcare landscape, highlighting market size, key players, and critical growth drivers. With a focus on emerging drug technologies, evolving treatment paradigms, and regulatory frameworks, the report delivers strategic insights to support stakeholders in navigating the rapidly advancing sector from 2025 to 2033.

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Idiopathic Hypersomnia is a rare neurological disorder marked by excessive daytime sleepiness despite adequate rest. The treatment market is expanding due to recent FDA-approved therapies (e.g., low-sodium oxybate), growing diagnosis rates, and rising demand for CNS-targeted sleep disorder drugs.

Idiopathic Hypersomnia Treatment Market Competitors Overview:

Jazz Pharmaceuticals plc, Harmony Biosciences Holdings, Inc., AVADEL PHARMACEUTICALS PLC, Zevra Therapeutics, Inc., Teva Pharmaceuticals USA, Inc., Mylan N.V., Hoffmann-La Roche Limited, BIOPROJET, Theranexus, Shionogi Inc. and among others.

Important Industry Updates of 2023, 2024 and 2025:

✅ In December 2024 - FDA approved olezarsen, marketed as Tryngolza, for adults with familial chylomicronemia syndrome (FCS) to reduce triglycerides as adjunct to diet. It's the first FDA-approved treatment for FCS, based on the Phase 3 Balance trial demonstrating ~57% TG reduction at six months
Cutaneous Lupus Erythematosus

✅ Late 2024 - early 2025 - Plozasiran (Arrowhead's ApoC‐III siRNA) completed a positive Phase 3 trial in FCS (~80% TG reduction) and plans regulatory filings; NDA accepted by FDA on January 17, 2025, with PDUFA target date: November 18, 2025

Methodology and Scope

The Idiopathic Hypersomnia Treatment Market Report is built on a rigorous research methodology that integrates primary interviews, expert insights, and validated secondary data from company reports, industry publications, and reliable databases. Utilizing both bottom-up and top-down approaches, the analysis ensures high data accuracy through triangulation. The report covers current market dynamics, growth opportunities, and key strategic developments across global and regional markets.

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Idiopathic Hypersomnia Treatment Market Segments Overview:

∎ By Treatment Type(Non-Stimulant Wake-Promoting Medications (Modafinil, Armodafinil, Solriamfetol, Pitolisant and Others), CNS Depressants(Xyrem , Xywav), Psychostimulants(Amphetamines, Methylphenidate, Others) and Others)
∎ By Distribution Channel(Hospital Pharmacies, Retail Pharmacies, Online Pharmacies)

Regional Overview for Idiopathic Hypersomnia Treatment Market:

⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

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