Diabetes Clinical, Companies, Therapeutic Assessment, Therapies, Treatment Algorithm, Pipeline Analysis | vTv Therapeutics, Eli Lilly and Company, Sciwind Biosciences, AstraZeneca, Neurodon, Regor Therapeutics, Abarceo Pharma, Chong Kun Dang Pharmaceutica

Diabetes Pipeline constitutes 200+ key companies continuously working towards developing 200+ Diabetes treatment therapies, analyzes DelveInsight.

Diabetes Overview:

Diabetes is a long-term metabolic condition marked by elevated blood glucose levels, resulting from the body's inability to produce adequate insulin or utilize it efficiently. Insulin is a crucial hormone responsible for regulating blood sugar. The condition primarily manifests in two forms: Type 1 diabetes, an autoimmune disorder in which the immune system destroys insulin-producing cells in the pancreas, and Type 2 diabetes, the more prevalent form, typically linked to insulin resistance and influenced by factors like poor diet and obesity. Other less common forms include gestational diabetes, which occurs during pregnancy, and rarer variants such as Maturity-Onset Diabetes of the Young (MODY) and Latent Autoimmune Diabetes in Adults (LADA).

Symptoms of diabetes vary depending on its type and severity but often include increased thirst and frequent urination, as the body attempts to eliminate excess glucose through urine. Intense hunger, unexplained weight loss, fatigue, and blurry vision are also typical, caused by unstable blood sugar levels. Individuals with Type 2 diabetes may also experience slow-healing wounds, frequent infections, and numbness or tingling in the extremities, which are signs of nerve damage.

The underlying mechanisms of diabetes involve impaired blood glucose regulation due to problems with insulin. In Type 1 diabetes, an autoimmune attack eliminates the pancreatic beta cells responsible for producing insulin, resulting in little to no insulin in the body. This prevents glucose from entering cells for energy, causing blood sugar levels to rise. In Type 2 diabetes, the body's cells develop resistance to insulin, and the pancreas cannot produce enough insulin to overcome this resistance, gradually leading to hyperglycemia. Over time, persistent high blood sugar damages blood vessels, nerves, and vital organs, contributing to complications such as heart disease, nerve damage (neuropathy), eye disease (retinopathy), and kidney damage (nephropathy). A combination of genetic predisposition, environmental exposures, and lifestyle choices plays a significant role in the onset and development of the disease.

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"Diabetes Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Diabetes Therapeutics Market.

Key Takeaways from the Diabetes Pipeline Report

DelveInsight's Diabetes pipeline report depicts a robust space with 200+ active players working to develop 200+ pipeline therapies for Diabetes treatment.
In February 2025, the FDA approved Merilog, the first short-acting insulin biosimilar to Novolog, manufactured by Viatris. It joins two long-acting insulin biosimilars that were previously approved in 2021.
On January 28, 2025, the FDA granted approval for Ozempic-Novo Nordisk's GLP‐1 agonist-for reducing progression of chronic kidney disease and mortality in Type 2 diabetes patients with CKD. It is now the first GLP‐1 drug approved for this indication.
Key Diabetes companies such as vTv Therapeutics, Eli Lilly and Company, Sciwind Biosciences, AstraZeneca, Neurodon, Regor Therapeutics, Abarceo Pharma, Chong Kun Dang Pharmaceutical, Roche, Rivus Pharmaceuticals, Kallyope Inc, and others are evaluating new drugs for Diabetes to improve the treatment landscape.
Promising Diabetes pipeline therapies in various stages of development include K-833, XW014, HU6, CT-388, LY-3209590, Cadisegliatin, and others.

Diabetes Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Diabetes Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Diabetes treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Diabetes market.

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Diabetes Emerging Drugs

Cadisegliatin - vTv Therapeutics

Cadisegliatin (also known as TTP399) is a novel oral treatment developed by vTv Therapeutics, classified as a liver-selective glucokinase activator. Intended for use alongside insulin in patients with Type 1 diabetes (T1D), this drug enhances glucose uptake and glycogen synthesis in the liver, functioning independently of insulin. By targeting hepatic glucose metabolism, cadisegliatin addresses a critical gap in diabetes care. The therapy is currently undergoing Phase III clinical trials for the treatment of diabetes.
LY3209590 - Eli Lilly and Company

Insulin efsitora alfa (LY3209590) is a long-acting basal insulin analog engineered for once-weekly administration. It is a fusion protein that merges a modified single-chain insulin molecule with a human IgG2 Fc fragment. Designed for subcutaneous injection, efsitora offers a low peak-to-trough insulin ratio, aiming to maintain steady glucose levels with minimal fluctuations over the week. It is currently in Phase III development for both Type 1 and Type 2 diabetes in adult patients.
CT-388 - Roche

CT-388 is a once-weekly injectable therapy under development for managing obesity and Type 2 diabetes (T2D). It is a dual agonist targeting both GLP-1 and GIP receptors, designed to activate these receptors with high potency while minimizing β-arrestin recruitment. This approach reduces receptor internalization and desensitization, potentially extending the drug's therapeutic effects. CT-388 is currently in Phase II clinical trials for the treatment of Type 2 Diabetes Mellitus.

Diabetes Companies

There are over 200 prominent companies actively working on developing therapies for diabetes. Among them, vTv Therapeutics and Eli Lilly and Company have drug candidates that are currently in the most advanced stage of development-Phase III clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Diabetes pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Diabetes Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Diabetes Pipeline Therapeutic Assessment
• Diabetes Assessment by Product Type
• Diabetes By Stage
• Diabetes Assessment by Route of Administration
• Diabetes Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Diabetes Current Treatment Patterns
4. Diabetes - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Diabetes Late-Stage Products (Phase-III)
7. Diabetes Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Diabetes Discontinued Products
13. Diabetes Product Profiles
14. Diabetes Key Companies
15. Diabetes Key Products
16. Dormant and Discontinued Products
17. Diabetes Unmet Needs
18. Diabetes Future Perspectives
19. Diabetes Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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