Blastic Plasmacytoid Dendritic Cell Neoplasm Clinical, Companies, Therapeutic Assessment, Therapies, Treatment Algorithm, Pipeline Analysis | AbbVie, Sanofi

Blastic Plasmacytoid Dendritic Cell Neoplasm Pipeline constitutes 2+ key companies continuously working towards developing 2+ Blastic Plasmacytoid Dendritic Cell Neoplasm treatment therapies, analyzes DelveInsight.

Blastic Plasmacytoid Dendritic Cell Neoplasm Overview:

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, fast-progressing blood cancer arising from the malignant transformation of plasmacytoid dendritic cells-immune cells primarily responsible for antiviral defense and the production of type I interferons. The disease commonly begins with distinctive skin manifestations, such as purplish or dark nodules and plaques, and frequently spreads to the bone marrow, resulting in reduced blood cell counts (cytopenias), as well as to other organs including lymph nodes, spleen, and the central nervous system. Patients often experience systemic symptoms like fatigue, fever, and unexplained weight loss. Due to its aggressive behavior and high relapse rate, BPDCN carries a poor prognosis. Although it mostly affects older adults, younger individuals can also be diagnosed. Diagnosis typically involves a combination of skin biopsy, immunohistochemistry, and flow cytometry to confirm the presence of malignant cells. Even with intensive chemotherapy and stem cell transplantation, treatment success is often limited.

In 80-90% of cases, BPDCN initially presents with skin involvement, typically seen as bruise-like patches or raised lesions that are purple or brown in color, usually appearing on the head, face, or upper body. Symptoms may also include ongoing fatigue, fever, weight loss, and swollen lymph nodes-especially in the neck or groin. If the bone marrow is affected, patients may experience bone pain and develop cytopenias such as anemia, low platelet counts, or neutropenia, increasing the risk of infections and bleeding. Abdominal pain can occur if the spleen is enlarged, and central nervous system involvement may lead to neurological issues like headaches or confusion. Given the disease's rapid progression and multi-organ involvement, early and aggressive treatment is essential to improve patient outcomes.

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"Blastic Plasmacytoid Dendritic Cell Neoplasm Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Blastic Plasmacytoid Dendritic Cell Neoplasm Therapeutics Market.

Key Takeaways from the Blastic Plasmacytoid Dendritic Cell Neoplasm Pipeline Report

DelveInsight's Blastic Plasmacytoid Dendritic Cell Neoplasm pipeline report depicts a robust space with 2+ active players working to develop 2+ pipeline therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm treatment.
Tagraxofusp, a CD123-directed fusion protein combining IL‐3 and diphtheria toxin, received FDA approval on July 11, 2025, for BPDCN as part of a treatment-to-transplant ("bridge to SCT") strategy. Its approval is grounded in findings from the STML‐401‐0114 clinical trial.
Key Blastic Plasmacytoid Dendritic Cell Neoplasm companies such as AbbVie, Sanofi, and others are evaluating new drugs for Blastic Plasmacytoid Dendritic Cell Neoplasm to improve the treatment landscape.
Promising Blastic Plasmacytoid Dendritic Cell Neoplasm pipeline therapies in various stages of development include Pivekimab sunirine, and others.

Blastic Plasmacytoid Dendritic Cell Neoplasm Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Blastic Plasmacytoid Dendritic Cell Neoplasm Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Blastic Plasmacytoid Dendritic Cell Neoplasm treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Blastic Plasmacytoid Dendritic Cell Neoplasm market.

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Blastic Plasmacytoid Dendritic Cell Neoplasm Emerging Drugs

Pivekimab sunirine: AbbVie
Pivekimab sunirine (developed by AbbVie) is an antibody-drug conjugate (ADC) targeting CD123, currently in clinical development for treating hematologic cancers, including blastic plasmacytoid dendritic cell neoplasm (BPDCN). The drug incorporates a specialized indolinobenzodiazepine (IGN) payload developed by ImmunoGen, which works by alkylating DNA and inducing single-strand breaks without forming crosslinks. These IGNs are engineered to be highly potent against cancer cells while showing reduced toxicity toward healthy bone marrow progenitors compared to other DNA-targeting agents.

Blastic Plasmacytoid Dendritic Cell Neoplasm Companies

There are over two major companies currently working on therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). Among them, AbbVie has a drug candidate that is in the most advanced stage of development-Phase II clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Blastic Plasmacytoid Dendritic Cell Neoplasm pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Blastic Plasmacytoid Dendritic Cell Neoplasm Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Blastic Plasmacytoid Dendritic Cell Neoplasm Pipeline Therapeutic Assessment
• Blastic Plasmacytoid Dendritic Cell Neoplasm Assessment by Product Type
• Blastic Plasmacytoid Dendritic Cell Neoplasm By Stage
• Blastic Plasmacytoid Dendritic Cell Neoplasm Assessment by Route of Administration
• Blastic Plasmacytoid Dendritic Cell Neoplasm Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Blastic Plasmacytoid Dendritic Cell Neoplasm Current Treatment Patterns
4. Blastic Plasmacytoid Dendritic Cell Neoplasm - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Blastic Plasmacytoid Dendritic Cell Neoplasm Late-Stage Products (Phase-III)
7. Blastic Plasmacytoid Dendritic Cell Neoplasm Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Blastic Plasmacytoid Dendritic Cell Neoplasm Discontinued Products
13. Blastic Plasmacytoid Dendritic Cell Neoplasm Product Profiles
14. Blastic Plasmacytoid Dendritic Cell Neoplasm Key Companies
15. Blastic Plasmacytoid Dendritic Cell Neoplasm Key Products
16. Dormant and Discontinued Products
17. Blastic Plasmacytoid Dendritic Cell Neoplasm Unmet Needs
18. Blastic Plasmacytoid Dendritic Cell Neoplasm Future Perspectives
19. Blastic Plasmacytoid Dendritic Cell Neoplasm Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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