Traumatic Brain Injury Clinical, Companies, Therapeutic Assessment, Therapies, Treatment Algorithm, Pipeline Analysis | Oragenics, SHINKEI Therapeutics, AlzeCure, Algernon Pharmaceutical, Mitochon Pharmaceuticals, Hoth Therapeutics, Biomed Industries, Bio

Traumatic Brain Injury Pipeline constitutes 20+ key companies continuously working towards developing 22+ Traumatic Brain Injury treatment therapies, analyzes DelveInsight.

Traumatic Brain Injury Overview:

Traumatic brain injury (TBI) results from an external impact-such as a strike, bump, or jolt to the head or body-that causes damage to the brain. The severity of TBI can vary, ranging from mild cases that cause short-term cognitive or physical issues to severe cases that may lead to lasting disability or even death. TBIs are categorized into primary injuries, where the damage occurs at the moment of trauma, and secondary injuries, which develop over time as a result of biological responses to the initial injury. TBI can affect a wide range of brain functions, including cognition, movement, communication, and emotional regulation.

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"Traumatic Brain Injury Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Traumatic Brain Injury Therapeutics Market.

Key Takeaways from the Traumatic Brain Injury Pipeline Report

DelveInsight's Traumatic Brain Injury pipeline report depicts a robust space with 20+ active players working to develop 22+ pipeline therapies for Traumatic Brain Injury treatment.
In April 2024, the FDA cleared Abbott's i-STAT cartridge, which assesses mild TBI (concussion) at the bedside using whole blood. It delivers lab-quality results in about 15 minutes, aiding clinicians in deciding whether a CT scan is needed.
Key Traumatic Brain Injury companies such as Oragenics, SHINKEI Therapeutics, AlzeCure, Algernon Pharmaceutical, Mitochon Pharmaceuticals, Hoth Therapeutics, Biomed Industries, BioArctic, Tiziana Life Sciences, TikoMed AB, Levolta Pharmaceuticals, Boulder BioScience, International Stem Cell Corporation, Revalesio Corporation, Teleport Pharmaceuticals, and others are evaluating new drugs for Traumatic Brain Injury to improve the treatment landscape.
Promising Traumatic Brain Injury pipeline therapies in various stages of development include AP-188, ACD 856, MR-301, ONP-002, and others.

Traumatic Brain Injury Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Traumatic Brain Injury Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Traumatic Brain Injury treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Traumatic Brain Injury market.

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Traumatic Brain Injury Emerging Drugs

ONP-002: Oragenics, Inc.

ONP-002 is a first-in-class enantiomeric neurosteroid under development for treating mild Traumatic Brain Injury (mTBI), commonly referred to as concussion. This compound penetrates cells and interacts with steroid receptors located in neurons, glial cells, and the endothelial lining of the blood-brain barrier. Upon activation, these receptors trigger multiple gene regulatory pathways, resulting in the production of mRNA and proteins that help alleviate inflammation, oxidative damage, and brain swelling. Additionally, ONP-002 promotes macro-autophagy, a cellular process that helps clear accumulated debris both inside and outside cells-an important mechanism for preventing chronic neurodegenerative conditions linked to dementia. ONP-002 is currently in Phase II clinical development for the treatment of traumatic brain injury.

MR-301: SHINKEI Therapeutics, Inc

MR-301 - Amantadine HCl Intravenous (IV) Solution is the lead investigational therapy in SHINKEI's pipeline. Amantadine HCl is widely used off-label to manage prolonged disorders of consciousness following traumatic brain injury (TBI). It works by enhancing dopamine availability in the synaptic cleft through inhibition of dopaminergic receptor activation. Approved in the U.S. since 1966 as an oral medication, Amantadine HCl has a well-established safety profile both domestically and internationally. Early research in animal models and TBI patients has indicated that the drug may support functional recovery while maintaining a strong safety record. MR-301 is currently undergoing Phase II clinical trials for the treatment of traumatic brain injury.

Traumatic Brain Injury Companies

Around 20 or more prominent companies are actively working on developing treatments for Traumatic Brain Injury (TBI). Among these, Oragenics, Inc. is one of the companies with a drug candidate currently in the most advanced stage of development-Phase II clinical trials.

DelveInsight's report covers around 75+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Traumatic Brain Injury pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Traumatic Brain Injury Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Traumatic Brain Injury Pipeline Therapeutic Assessment
• Traumatic Brain Injury Assessment by Product Type
• Traumatic Brain Injury By Stage
• Traumatic Brain Injury Assessment by Route of Administration
• Traumatic Brain Injury Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Traumatic Brain Injury Current Treatment Patterns
4. Traumatic Brain Injury - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Traumatic Brain Injury Late-Stage Products (Phase-III)
7. Traumatic Brain Injury Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Traumatic Brain Injury Discontinued Products
13. Traumatic Brain Injury Product Profiles
14. Traumatic Brain Injury Key Companies
15. Traumatic Brain Injury Key Products
16. Dormant and Discontinued Products
17. Traumatic Brain Injury Unmet Needs
18. Traumatic Brain Injury Future Perspectives
19. Traumatic Brain Injury Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

This release was published on openPR.