Oligonucleotide Synthesis Modification and Purification Services Market Set to Grow Rapidly Driven by Therapeutic and Diagnostic Applications Expansion

InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the " Global Oligonucleotide Synthesis, Modification and Purification Services Market Oligonucleotide Mfg. Type (Antisense Oligonucleotides, siRNA, miRNA, And Other Oligonucleotides), Applications (Research And Diagnostic, Therapeutic, And Contract Manufacturing (OEM)), Operation Scale (Large-Scale Oligonucleotide Synthesis, Intermediate-Scale Oligonucleotide Synthesis, And Small-Scale Oligonucleotide Synthesis), Therapeutic Areas (Oncological Disorders, Eye Disorders, Metabolic Disorders, Autoimmune Disorders, And Other Therapeutic Areas), End-users (Pharmaceutical & Biotechnology Companies, Hospitals & Diagnostic Laboratories, Contract Research Organizations (Cros) And Contract Manufacturing Organizations (Cmos), And Academic Research Institutes) - Trends, Industry Competition Analysis, Revenue, and Forecast till 2034."

According to the latest research by InsightAce Analytic, the global oligonucleotide synthesis, modification, and purification services market was valued at USD 4.69 billion in 2024 and is predicted to reach USD 12.27 billion by the year 2034 at an 10.02 % CAGR during the forecast period for 2025-2034.

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Major market players operating in the oligonucleotide synthesis, modification, and purification services market include Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players.

There has been a growing interest in the application of modified oligoribonucleotides across the fields of molecular biology, biochemistry, and medicine. Oligonucleotides, defined as short, single-stranded DNA or RNA molecules, are synthetically produced via solid-phase synthesis and are extensively utilized in various molecular biology techniques, including PCR, real-time PCR, sequencing, site-directed mutagenesis, single nucleotide polymorphism (SNP) assays, microarrays, as well as diverse therapeutic applications. Chemically modified oligonucleotides have been the focus of extensive research for the development of novel antisense and siRNA therapies.

To facilitate the timely production of innovative vaccines and pharmaceutical products, companies increasingly require robust and reliable tools for the characterization and monitoring of oligonucleotide and mRNA products.

The demand for oligonucleotides is expected to rise during the forecast period, driven by factors such as the growing need for custom, high-quality oligos in next-generation sequencing (NGS) applications, advancements in synthesis and purification technologies, a surge in product launches by key market players, a high prevalence of chronic and genetic disorders, an expanding geriatric population, increased custom oligonucleotide synthesis services, and intensified research and development efforts within biotechnology firms aimed at enhancing oligo synthesis and purification processes.

Moreover, strategic initiatives such as the expansion of manufacturing capabilities and partnerships, mergers, and collaborations are projected to further propel market growth. For example, in February 2018, STA Pharmaceutical Co. (China), a WuXi AppTec group entity, entered into a collaboration agreement with Regulus Therapeutics (US) focused on oligonucleotide synthesis for research and mid-scale non-GMP/cGMP manufacturing. Similarly, in June 2017, CordenPharma International partnered with GE Healthcare's Dharmacon business to develop a comprehensive solution for oligonucleotide-based drug discovery.

Nonetheless, the high costs associated with purification processes, the complexity of manufacturing procedures, oligonucleotide degradation during generic research, and in-house development constraints are anticipated to pose challenges to the expansion of the global oligonucleotide synthesis, modification, and purification services market.

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Geographically, North America is projected to hold the highest share of this market over the forecast years, followed by Europe. Europe is expected to grow significantly in this market due to the availability of better healthcare infrastructures and the increasing usage of oligonucleotides to develop novel drug therapies.

Key Developments In The Market:
• In Oct 2021, TriLink BioTechnologies stated that it plans to provide EyeGene, Inc. with its CleanCap® mRNA capping process and the modified nucleoside, uridine triphosphate, for the manufacturing of EyeGene's mRNA COVID-19 vaccine. This cooperation with EyeGene is anticipated to be the first clinical-stage initiative to utilise TriLink's GMP-grade modified uridine triphosphate designed for further processing.
• In June 2021, Thermo Fisher Scientific teamed up to build end-to-end procedures for complicated oligonucleotide and mRNA products. This collaboration combines the University of Sheffield's research expertise with Thermo Fisher's sample preparation, liquid chromatography (LC), high-resolution accurate-mass (HRAM), mass spectrometry (MS), and data interpretation software technologies to develop streamlined analytical workflows and robust fit-for-purpose processes.
• In January 2021, MilliporeSigma (US) acquired AmpTec, a leading Germany-based mRNA contract development and manufacturing organization (CDMO). The deal strengthens MilliporeSigma's capabilities to develop and manufacture mRNA for its customers for use in vaccines, treatments, and diagnostics applicable in Covid-19 and many other diseases.
• In September 2019, GeneDesign (Japan) acquired Ajinomoto Bio-Pharma Services, becoming part of the contract development and manufacturing organization (CDMO). The integration of GeneDesign's services offerings with Aji Bio-Pharma's small and large molecule capabilities in the U.S., Belgium, and India strengthens the CDMO's capabilities.
• In 2019, Integrated DNA Technology (US) launched 'oPools- oligo pools', a pool of high-quality DNA oligonucleotides with 350 nucleotides in length.

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Market Segments
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by By Oligonucleotide mfg. Types, 2022-2030 (Value US$ Bn)
• Antisense Oligonucleotides
• siRNA
• shRNA
• miRNA
• Aptamers
• Primers
• Probes
• Others (Adapters for NSG)
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Applications, 2022-2030 (Value US$ Bn)
• Research and Diagnostic
o PCR
o qPCR/RTqPCR
o Sequencing
o Gene Synthesis
o Other Research Applications
• Therapeutic
o RNAi Oligonucleotide-based Therapies
o DNA/Antisense oligonucleotide-based Therapies
o Immunotherapy (CpG Oligonucleotide-based Therapies)
o Nucleic Acid Aptamer
• Contract Manufacturing
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Operation Scale, 2022-2030 (Value US$ Bn)
• Large-Scale Oligonucleotide Synthesis
• Intermediate-Scale Oligonucleotide Synthesis
• Small-Scale Oligonucleotide Synthesis
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Therapeutic Areas, 2022-2030 (Value US$ Bn)
• Oncological Disorders
• Eye Disorders
• Metabolic Disorders
• Autoimmune Disorders
• Other Therapeutic Areas
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by End-Users, 2022-2030 (Value US$ Bn)
• Pharmaceutical & Biotechnology Companies
• Hospitals & Diagnostic Laboratories
• Contract research organisations (CROs) and contract manufacturing organisations (CMOs)
• Academic Research Institutes
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region, 2022-2030 (Value US$ Bn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• U.S.
• Canada
Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa

Why should buy this report:
 To receive a comprehensive analysis of the prospects for the global oligonucleotide synthesis, modification, and purification services market
 To receive an industry overview and future trends of the oligonucleotide synthesis, modification, and purification services market
 To analyze the oligonucleotide synthesis, modification, and purification services market drivers and challenges
 To get information on the oligonucleotide synthesis, modification, and purification services market size value (US$ Mn) forecast to 2030
 Major Investments, Mergers & Acquisition in the oligonucleotide synthesis, modification, and purification services market industry

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