Press release
CD47 Targeting Therapeutics Market Analysis Highlighting Rapid Expansion Driven by Cancer Treatment Innovations
CD47 Targeting Therapeutics Market
A transmembrane protein called CD47 helps cancer cells survive in various cancer types by glycosylating on the surface of numerous cancer cells. When CD47 binds to the signal-regulatory protein SIRP, it starts an inhibitory signalling pathway in many cancer types that stops malignant cells from being phagocytosed by macrophages. Therefore, blocking the CD47-SIRP signalling pathway can promote macrophage phagocytosis of tumour cells.
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The global CD47-targeting therapeutics market growth is driven by several factors, including the increasing utilization of CD47-targeted anti-cancer treatments, an aging population, the high prevalence of various cancer types, and growing public awareness of the benefits associated with these therapies.
Over the forecast period, escalating research and development investments aimed at better understanding CD47-dependent signaling are expected to create new opportunities within the market. Enhanced knowledge in this field may facilitate the development of innovative anti-cancer therapies that inhibit CD47 signaling in malignant cells. However, market expansion may be hindered by challenges such as the high production costs and manufacturing complexities of targeted therapies, potential off-target effects damaging healthy cells, and stringent regulatory requirements for therapeutic approvals.
Regionally, North America is projected to be a significant contributor to the CD47-targeting therapeutics market throughout the forecast period, driven by rising cancer incidence and mortality rates, along with the rapid adoption of novel drugs and treatment modalities. The United States, in particular, plays a pivotal role by supporting extensive research and development initiatives focused on CD47-targeted therapies. Concurrently, the Asia Pacific market is anticipated to experience substantial growth, fueled by increasing use of CD47-targeting anti-cancer therapies, a growing elderly population, the high burden of diverse cancer types, and heightened awareness of the therapeutic advantages offered by CD47 inhibition in the region.
Major market players operating in the CD47 Targeting Therapeutics market include
Conjupro biotherapeutics (US), EpicentRx (US), Forty Seven (US), ImmuneOncia Therapeutics (Korea), ImmuneOnco Biopharmaceuticals (China), Innovent Biologics (China), KAHR Medical (Israel), TG Therapeutics, Adagene, Alector, Inc., Apmonia Therapeutics, I-MAB Biopharma Co., Ltd., Light Chain Bioscience (Switzerland), Morphiex (US), Trillium Therapeutics (Canada), QLSF Biotherapeutics Inc., Phanes Therapeutics, Inc., Bio-Thera Solutions, others.
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Recent collaborations and agreements in the market:
• In January 2022, the next-generation CD47 blocker evorpacept, manufactured by ALX Oncology, was accorded orphan drug designation ("ODD") for treating patients with gastroesophageal junction and gastric cancer.
• In September 2021, for US$2.3 billion, Pfizer Inc. (US) purchased Trillium Therapeutics Inc. (Canada), which had CD47 prospects. Pfizer now has a stronger cancer and hematology portfolio thanks to this acquisition.
• In June 2021, to test the efficacy of combining ALX148, a next-generation CD47 blocker, and CYRAMZA (ramucirumab), Lilly's anti-VEGFR2 antibody, for the treatment of gastric cancer, ALX Oncology (US) and Eli Lilly and Company (US) agreed into a clinical study partnership and supply agreement.
Market Segments
Global CD47 Targeting Therapeutics Market, by Target Disease Indication, 2022-2030 (Value US$ Mn)
• Acute Myeloid Leukemia
• Non-Hodgkin Lymphoma
• Colorectal Cancer
• Diffuse Large B-cell Lymphoma
• Myelodysplastic Syndromes
• Non-Small Cell Lung Cancers
• Ovarian Epithelial Cancer
• Oral mucositis
• Small Cell Lung Cancers
• Other Diseases Indications
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Global CD47 Targeting Therapeutics Market, by Type of Molecule, 2022-2030 (Value US$ Mn)
• Biologics
• Small Molecule
Global CD47 Targeting Therapeutics Market, by Region, 2022-2030 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America CD47 Targeting Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• U.S.
• Canada
Europe CD47 Targeting Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific CD47 Targeting Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America CD47 Targeting Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa CD47 Targeting Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• GCC Countries
• South Africa
o Rest of Middle East & Africa
Why should buy this report:
To receive a comprehensive analysis of the prospects for the global CD47 Targeting Therapeutics market
To receive an industry overview and future trends in the CD47 Targeting Therapeutics market
To analyze the CD47 Targeting Therapeutics market drivers and challenges
To get information on the CD47 Targeting Therapeutics market value (US$Mn) forecast to 2030
Significant investments, mergers & acquisitions in the CD47 Targeting Therapeutics market industry
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About Us:
InsightAce Analytic is a market research and consulting firm that enables clients to make strategic decisions. Our qualitative and quantitative market intelligence solutions inform the need for market and competitive intelligence to expand businesses. We help clients gain competitive advantage by identifying untapped markets, exploring new and competing technologies, segmenting potential markets and repositioning products. Our expertise is in providing syndicated and custom market intelligence reports with an in-depth analysis with key market insights in a timely and cost-effective manner.
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