Press release
Humanized Liver Mice Model Market Driven by Advancements in Drug Discovery and Testing
✅ Humanized Liver Mice Model Market: Unlocking the Future of Preclinical ResearchThe humanized liver mice model market is rapidly gaining momentum due to the increasing demand for accurate and reliable preclinical models in drug discovery, hepatotoxicity testing, and infectious disease research. These mice, genetically engineered to carry functioning human liver cells, offer a more realistic simulation of human liver function compared to traditional animal models. In 2025, the market is estimated to be valued at US$ 105.6 million, and it is forecasted to reach US$ 176.2 million by 2032, registering a CAGR of 7.5% from 2025 to 2032.
One of the key growth drivers is the surge in pharmaceutical R&D activities, particularly related to liver diseases, cancer therapeutics, and metabolic disorders. Humanized liver mice have emerged as indispensable tools in the evaluation of drug metabolism and pharmacokinetics (DMPK). Among all segments, uPA-SCID mice dominate due to their high compatibility with human hepatocytes. North America leads the global market, primarily due to robust research infrastructure, increased funding for biotechnology, and higher adoption of advanced research models in the U.S.
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✅ Key Highlights from the Report
➤The market is expected to grow at a CAGR of 7.5% between 2025 and 2032.
➤uPA-SCID mice account for the largest market share due to superior engraftment efficiency.
➤North America holds the leading regional share owing to advanced R&D capabilities.
➤Contract Research Organizations (CROs) are major end-users driving demand.
➤The rising prevalence of liver-related diseases is fueling model usage in drug testing.
➤Biopharmaceutical companies are increasingly investing in humanized liver mice models.
✅ What Are Humanized Liver Mice and Why Are They Important?
What are humanized liver mice used for, and how do they contribute to modern drug development?
Humanized liver mice are genetically modified rodent models in which human liver cells (hepatocytes) are transplanted to mimic human liver functions. These models are essential for studying human-specific liver metabolism, drug toxicity, and liver-targeted therapeutics. Due to the significant limitations of traditional murine models, particularly in replicating human-specific responses to drugs and infections, humanized liver mice offer a high-fidelity platform to conduct ADME (Absorption, Distribution, Metabolism, and Excretion) studies. They are particularly vital in hepatitis virus research (HBV, HCV), preclinical testing of liver-targeted drugs, and understanding liver fibrosis and cancer mechanisms. These mice help reduce clinical trial failures by offering more accurate predictions of drug efficacy and toxicity. Consequently, pharmaceutical companies, biotech firms, and research institutes globally are integrating humanized mice into their preclinical testing pipelines, making them invaluable tools in bridging the gap between in vitro research and clinical trials.
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✅ Market Segmentation
The humanized liver mice model market is segmented based on model type, such as uPA-SCID mice, FRG mice, and TK-NOG mice. Among these, uPA-SCID mice hold a dominant position, thanks to their high level of human liver chimerism and compatibility with human hepatocytes. FRG mice are also gaining traction due to their ability to support chronic infections like hepatitis and fatty liver diseases, enabling long-term studies of disease progression and treatment responses.
Based on end-users, the market is categorized into pharmaceutical & biotechnology companies, academic & research institutions, and contract research organizations (CROs). CROs are becoming prominent players due to the increasing trend of outsourcing preclinical studies. Biopharmaceutical firms leverage these models for screening drug candidates and minimizing the risks of drug-induced liver injury (DILI), while academic institutions focus on liver disease mechanisms and gene therapy validations.
✅ Regional Insights
North America is the largest regional market, accounting for a significant share due to high R&D spending, government funding, and the presence of top pharmaceutical firms. The United States remains a global leader in employing humanized mice models for preclinical drug testing and liver disease research.
In contrast, the Asia Pacific region is witnessing rapid market growth, propelled by expanding pharmaceutical industries in China, India, and Japan. Increasing investments in biotechnology research and the growing prevalence of liver disorders are major factors fueling regional demand.
✅ Market Drivers
The increasing global burden of chronic liver diseases, such as non-alcoholic fatty liver disease (NAFLD), hepatitis B and C, and liver cancer, is propelling demand for more realistic preclinical testing models. Moreover, humanized liver mice are becoming indispensable for evaluating drug metabolism and toxicity, especially in the early stages of drug development. The rise in biotech innovations and the shift toward personalized medicine are further driving interest in these advanced models.
✅ Market Restraints
Despite their advantages, the market faces several challenges, such as high production costs, technical complexities, and limited availability of human hepatocytes. Furthermore, ethical considerations around the genetic modification of animals may restrict adoption in certain regions. These constraints, combined with a lack of standardization across laboratories, can pose barriers to widespread acceptance.
✅ Market Opportunities
Advancements in gene editing technologies like CRISPR and increasing collaborations between academic institutions and industry players are expected to open new avenues for market expansion. There's also a growing opportunity in developing countries where investment in biomedical research is accelerating. Additionally, the use of humanized liver mice in infectious disease modeling, such as for hepatitis virus research, presents a promising future application.
✅ Reasons to Buy the Report
☑️Gain access to in-depth analysis of market trends, segmentation, and forecasts.
☑️Identify key growth drivers, challenges, and untapped opportunities in the market.
☑️Understand the competitive landscape and key players' strategic moves.
☑️Stay updated on recent developments and innovations in humanized liver mouse models.
☑️Make informed business decisions with reliable data and market projections up to 2032.
✅ Company Insights
✦Yecuris Corporation
✦PhoenixBio Co., Ltd.
✦Taconic Biosciences, Inc.
✦The Jackson Laboratory
✦In Vivo Sciences, Inc.
✦Hera Biolabs
✦Genoway S.A.
✦JAX Mice
✦Horizon Discovery Ltd.
✦Charles River Laboratories
■In 2024, PhoenixBio expanded its humanized mouse platform to improve hepatitis B research efficiency.
■In 2023, Taconic Biosciences partnered with biotech firms to offer customized liver-humanized models for specific drug toxicity testing.
✅ Conclusion
The humanized liver mice model market is poised for strong growth, driven by the urgent need for accurate, human-relevant preclinical testing platforms. As pharmaceutical and biotech companies intensify their efforts to reduce drug development failures and improve patient outcomes, these advanced models are playing an increasingly crucial role. With advancements in genetic engineering and expanding R&D investments globally, the market is set to witness transformative changes in the years ahead. Companies that leverage these models effectively stand to gain a strategic advantage in drug discovery and development.
✅About Persistence Market Research:
At Persistence Market Research, we specialize in creating research studies that serve as strategic tools for driving business growth. Established as a proprietary firm in 2012, we have evolved into a registered company in England and Wales in 2023 under the name Persistence Research & Consultancy Services Ltd. With a solid foundation, we have completed over 3600 custom and syndicate market research projects, and delivered more than 2700 projects for other leading market research companies' clients.
Our approach combines traditional market research methods with modern tools to offer comprehensive research solutions. With a decade of experience, we pride ourselves on deriving actionable insights from data to help businesses stay ahead of the competition. Our client base spans multinational corporations, leading consulting firms, investment funds, and government departments. A significant portion of our sales comes from repeat clients, a testament to the value and trust we've built over the years.
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