Genital Herpes Pipeline Insight 2025: Paving the Way for Long-Acting Therapies and Therapeutic Vaccines | DelveInsight

DelveInsight's "Genital Herpes - Pipeline Insight, 2025" report offers an in-depth analysis of the evolving pipeline targeting this chronic, incurable viral infection caused primarily by herpes simplex virus type 2 (HSV-2) and, increasingly, HSV-1. With current therapies limited to symptom suppression through daily antivirals, the need for long-acting, disease-modifying, and potentially curative approaches remains urgent.

The genital herpes pipeline is witnessing a surge of innovation, with candidates exploring novel modalities such as therapeutic vaccines, immune-based therapies, gene editing, and viral suppressants with extended half-lives. Standout developments include Rational Vaccines' live-attenuated HSV vaccine and Genocea's HSV-2-specific immunotherapy, both aiming to reduce viral shedding and recurrence. Vical's HSV-2 DNA vaccine and AiCuris's long-acting helicase-primase inhibitor pritelivir represent promising non-vaccine approaches with potential for episodic and suppressive treatment.

Biotech companies like AiCuris, United BioPharma, and GlaxoSmithKline are also investing in next-generation platforms, including mRNA and viral vectors, to target latent HSV reservoirs-a key challenge in developing curative therapies.

The report comprehensively tracks each candidate's mechanism of action, trial design, clinical efficacy, and regulatory milestones. With increasing focus on both treatment and transmission prevention, the field is advancing toward options that could reduce the lifetime burden of disease, lower partner transmission risk, and improve quality of life.

As 2025 unfolds, the genital herpes pipeline is positioned to redefine standards of care, shifting from short-term viral suppression to long-term control and, potentially, functional cure.

Interested in learning more about the current treatment landscape and the key drivers shaping the genital herpes pipeline? Click here: https://www.delveinsight.com/report-store/genital-herpes-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Key Takeaways from the Genital Herpes Pipeline Report
• DelveInsight's genital herpes pipeline analysis depicts a strong space with 18+ active players working to develop 20+ pipeline drugs for genital herpes treatment.
• The leading genital herpes companies include AiCuris, United BioPharma, GlaxoSmithKline, Assembly Biosciences, BioNTech, Innovative Molecules, and others are evaluating their lead assets to improve the genital herpes treatment landscape.
• Key genital herpes pipeline therapies in various stages of development include Pritelivir, UB-621, GSK 3943104, ABI-5366, BNT 163, IM-250, and others.
• In July 2025, Assembly Biosciences enrolled the first patient in its Phase Ib trial of oral ABI-5366 for recurrent genital herpes, marking a significant milestone in its partnership-driven clinical development.
• In June 2025, BioNTech announced the development of the BNT163 mRNA vaccine targeting HSV-2 genital lesions, highlighting a key R&D collaboration in the vaccine pipeline.
• In May 2025, Assembly Biosciences presented promising initial proof-of-concept data for ABI-5366 at ESCMID 2025, demonstrating progress in its long-acting antiviral pipeline and strengthening its strategic position.

Request a sample and discover the recent breakthroughs happening in the genital herpes pipeline landscape at https://www.delveinsight.com/report-store/genital-herpes-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Genital Herpes Overview
Genital herpes is a common sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though HSV-1 is increasingly responsible. Both are enveloped DNA viruses transmitted through direct contact. Due to their genetic similarity, HSV-1 and HSV-2 share many biological and antigenic features. Symptoms typically appear 2-12 days after exposure, presenting as painful blisters or sores around the genitals, buttocks, or thighs. Many women are unaware they have the infection, though initial outbreaks can be severe, especially in immunocompromised individuals like those with HIV. Diagnosis involves a physical exam and lab tests, including PCR, viral culture, or blood tests to detect HSV antibodies. First-line treatments include acyclovir, valacyclovir, and famciclovir, which are antiviral drugs that inhibit viral DNA replication. These agents interfere with viral polymerase by mimicking nucleosides, effectively stopping the virus from multiplying.

Find out more about genital herpes medication at https://www.delveinsight.com/report-store/genital-herpes-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Genital Herpes Treatment Analysis: Drug Profile
Pritelivir: AiCuris
Pritelivir is a novel antiviral agent that potently inhibits HSV replication through a unique mechanism, blocking the viral helicase-primase complex. Unlike traditional nucleoside analogues, it does not require activation by viral enzymes, allowing it to protect uninfected cells more effectively. Pritelivir is currently in Phase III clinical trials for the treatment of genital herpes, particularly in immune-compromised patients with acyclovir-resistant or dual-resistant HSV infections.

UB-621: United BioPharma
UB-621 is a first-in-class anti-gD monoclonal antibody designed to target herpes simplex virus (HSV), particularly for recurrent genital HSV-2 infections in adults. It has demonstrated strong efficacy in reducing both transmission and recurrence of HSV-1 and HSV-2. The therapy is currently undergoing Phase II clinical development for genital herpes.

GSK 3943104: GlaxoSmithKline
GSK-3943104A is an investigational therapeutic vaccine developed by GlaxoSmithKline for the prevention of recurrent HSV-2 genital herpes. This vaccine candidate aims to reduce the frequency and severity of outbreaks. It is currently in Phase II clinical trials.

Learn more about the novel and emerging genital herpes pipeline therapies at https://www.delveinsight.com/report-store/genital-herpes-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Genital Herpes Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Oral
• Parenteral
• Intravenous
• Subcutaneous
• Topical

By Molecule Type
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Scope of the Genital Herpes Pipeline Report
• Coverage: Global
• Key Genital Herpes Companies: AiCuris, United BioPharma, GlaxoSmithKline, Assembly Biosciences, BioNTech, Innovative Molecules, and others.
• Key Genital Herpes Pipeline Therapies: Pritelivir, UB-621, GSK 3943104, ABI-5366, BNT 163, IM-250, and others.

To dive deep into rich insights for drugs used for genital herpes treatment, visit: https://www.delveinsight.com/report-store/genital-herpes-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Table of Contents
1. Introduction
2. Executive Summary
3. Genital Herpes Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Genital Herpes Pipeline Therapeutics
6. Genital Herpes Pipeline: Late-Stage Products (Phase III)
7. Genital Herpes Pipeline: Mid-Stage Products (Phase II)
8. Genital Herpes Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

Contact Us:
Jatin Vimal
jvimal@delveinsight.com
+14699457679
Healthcare Consulting
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About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform, PharmDelve.

This release was published on openPR.