Complex Regional Pain Syndrome Market Growth Driven by Rising Diagnosis Rates and Novel Therapies 2025-2033

Global complex regional pain syndrome market reached US$ 104.10 million in 2023 and is expected to reach US$ 710.2 million by 2031, growing at a CAGR of 2.5% during the forecast period 2024-2031.

Complex Regional Pain Syndrome Market Report by DataM Intelligence offers a detailed assessment of the global pharmaceutical and healthcare landscape, highlighting market size, key players, and critical growth drivers. With a focus on emerging drug technologies, evolving treatment paradigms, and regulatory frameworks, the report delivers strategic insights to support stakeholders in navigating the rapidly advancing sector from 2025 to 2033.

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Complex Regional Pain Syndrome (CRPS) is a chronic pain condition usually affecting limbs after injury or surgery, marked by severe pain, swelling, and changes in skin color or temperature. The market is growing steadily with increasing awareness, advancements in pain management therapies, and rising use of neuromodulation, physical therapy, and pharmacological options.

Complex Regional Pain Syndrome Market Competitors Overview:

Boston Scientific Corporation, Medtronic plc, Abbott Laboratories, Nevro Corp., St. Jude Medical, Saluda Medical Pty Ltd., Almatica Pharma LLC, Johnson & Johnson Consumer Inc., Biotronik SE & Co. KG and GIMER Medical among others.

Important Industry Updates of 2023, 2024 and 2025:

✅ In September 2023, Sun Pharma acquired a biotech company specializing in chronic pain, including CRPS, to strengthen its pain management portfolio.

✅ In October 2023, Amgen launched a new neuroinflammation-targeted therapy specifically aimed at CRPS, expanding its non-opioid pain treatment capabilities.

✅ In August 2023, Pfizer entered a partnership with a digital health company to combine pharmacological and digital therapies for CRPS treatment.

✅ In 2024 Axsome Therapeutics has been conducting a Phase 3 trial, called CREATE-1, for AXS-02, a zoledronate-based oral therapy, which began enrolling patients

✅ Grünenthal, in collaboration with Abiogen, received FDA Breakthrough Therapy Designation in early 2025 for neridronic acid, an oral bisphosphonate treatment. The therapy is currently in Phase 3 trials, with anticipated topline data by late 2025 or early 2026.

Methodology and Scope

The Complex Regional Pain Syndrome Market Report is built on a rigorous research methodology that integrates primary interviews, expert insights, and validated secondary data from company reports, industry publications, and reliable databases. Utilizing both bottom-up and top-down approaches, the analysis ensures high data accuracy through triangulation. The report covers current market dynamics, growth opportunities, and key strategic developments across global and regional markets.

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Complex Regional Pain Syndrome Market Segments Overview:

∎ By Disease Type (Type I CRPS, Type II CRPS, CRPS - Not Otherwise Specified (CRPS-NOS))
∎ By Treatment Type (Medications, Therapies, Others)
∎ By Sales Channel (End-User, Distribution Channel)

Regional Overview for Complex Regional Pain Syndrome Market:

⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

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