Press release
Antisense Oligonucleotide Therapeutics Market to Hit $9.1 Billion by 2034, Fueled by RNA Targeting Innovations
Antisense Oligonucleotide Therapeutics Market
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Antisense oligonucleotides (ASOs) are short, single-stranded sequences of DNA or RNA engineered to bind specifically to messenger RNA (mRNA) within cells. By interfering with mRNA translation, ASOs effectively prevent the production of disease-related proteins without impacting proteins that have already been synthesized. This targeted mechanism of action positions ASOs as a promising therapeutic approach for a broad range of medical conditions, including diabetes, asthma, alopecia, inflammatory diseases, and central nervous system disorders.
Beyond their therapeutic applications, ASOs are extensively utilized in genomic research to investigate gene expression and regulatory mechanisms. Approved antisense therapies such as mipomersen, used to treat elevated cholesterol levels, and fomivirsen, indicated for cytomegalovirus (CMV) retinitis, underscore the clinical potential of this technology. The ability of ASOs to precisely regulate gene expression at the mRNA level has made them a key component in the advancement of precision medicine, particularly in addressing genetic diseases.
The global antisense oligonucleotide therapeutics market is experiencing growth fueled by increased acceptance of antisense-based treatments, rising investments in research and development, the growing incidence of neurological disorders, and an aging population. Regulatory endorsements from authorities such as the U.S. Food and Drug Administration (FDA) for newly developed ASO therapies are expected to further support market expansion.
Additionally, strategic partnerships and acquisitions aimed at enhancing therapeutic pipelines are anticipated to accelerate market development.
Nonetheless, the high cost of ASO-based therapies and the presence of alternative synthetic treatment options may pose challenges to market growth. Regulatory complexities also remain a concern for industry stakeholders. Despite these constraints, sustained investment by key market participants is projected to unlock new opportunities and drive robust revenue growth over the forecast period.
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Regionally, Europe is expected to be a key contributor to the antisense oligonucleotide therapeutics market, supported by increasing adoption of innovative antisense drugs. Prominent European companies are focusing on strategic mergers and acquisitions, alongside efforts to enhance their antisense oligonucleotide product portfolios, further strengthening the region's market position.
In addition, the North American Antisense Oligonucleotide Therapeutics market is expected to grow significantly during the forecast period. Several biotechnology firms have invested a lot of money in creating RNAi medicines. Giant pharmaceutical corporations have entered into partnerships or license agreements with several smaller businesses to benefit from the anticipated revenue growth in this market over the projection period.
Major market players operating in the Antisense Oligonucleotide Therapeutics market include Pharmaceuticals, Inc., Sarepta Therapeutics, Biogen, Alnylam Pharmaceuticals, Inc., Antisense Therapeutics Limited, Sarna Therapeutics GmbH, Arrowhead Pharmaceuticals, Inc., Atlantic Pharmaceuticals, Inc., GlaxoSmithKline plc, Gerona Corporation, Gradualist, ICO Therapeutics, Aptos Biosciences, Enzo Pharmaceuticals, Inc., Bio-Path Holdings, Inc., Gene Signal International SA, Marina Biotech, mirage Therapeutics, Inc., Synodic, Inc., Oncogene Pharmaceuticals Inc., Pharm axis Ltd, Regulus Therapeutics Inc., Reran Pharmaceuticals, Inc., and RI Pharmaceuticals, among others.
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Recent collaborations and agreements in the market:
• In January 2021, MilliporeSigma (US) acquired AmpTec, a well-known German business specializing in contract development and manufacturing mRNA (CDMO).
• In August 2019, Integrated DNA Technology released tools- oligo pools, a set of 350-nucleotide-long, high-quality DNA oligonucleotides (US).
Market Segments
Global Antisense Oligonucleotide Therapeutics Market, by Therapy, 2022-2030 (Value US$ Mn)
• Monotherapy
• Combination
Global Antisense Oligonucleotide Therapeutics Market, by Molecule Target Indication, 2022-2030 (Value US$ Mn)
• DNA Molecule
• RNA Molecule
Global Antisense Oligonucleotide Therapeutics Market, by Target Indication, 2022-2030 (Value US$ Mn)
• Duchenne Muscular Atrophy
• Spinal Muscular Atrophy
• Familial Chylomicronemia Syndrome
• Amyotrophic Lateral Sclerosis
• Familial Partial Lipodystrophy
• Hereditary Transthyretin-Mediated (hatter) Amyloidosis
• Huntington's Disease
• Others
Global Antisense Oligonucleotide Therapeutics Market, by Region, 2022-2030 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• U.S.
• Canada
Europe Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• GCC Countries
• South Africa
o Rest of Middle East & Africa
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