Oligonucleotide Synthesis Market Landscape to 2034: Key Forces Shaping the Next Decade of Growth

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How Large Will the Oligonucleotide Synthesis Market Size By 2025?
The market for oligonucleotide synthesis has seen swift expansion in the recent past. Its growth is projected to increase from a valuation of $10.33 billion in 2024 to reach $11.94 billion by 2025, posting a compound annual growth rate (CAGR) of 15.6%. This historic growth surge is due to advancements in biomedical research, the development of therapeutics, innovations within the biotech sphere, increasing genomic studies, and the rise in DNA technologies.

How Big Is the Oligonucleotide Synthesis Market Size Expected to Grow by 2029?
In the forthcoming years, the market size for oligonucleotide synthesis is anticipated to experience a swift expansion, reaching $22.29 billion by 2029 with a compound annual growth rate (CAGR) of 16.9%. Rising diagnostic tools, RNA interference (RNAi) therapies, nanotechnology applications, developments in gene editing and regenerative medicine are factors contributing to this growth predicted for the forecast period. Also noteworthy among the forecast period trends are targeted drug development, next-generation sequencing (NGS), innovative delivery systems, automated synthesis, and CRISPR-cas technology.

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Which Key Market Drivers Powering Oligonucleotide Synthesis Market Expansion and Growth?
The oligonucleotide synthesis market is projected to grow, driven by the increasing prevalence of chronic diseases. These are conditions that last longer than a year, necessitating ongoing medical care, and their severity may progress over time. Oligonucleotides influence gene expression responsible for chronic diseases through several methods. They can key on mRNA, pre-mRNA, or non-coding RNA to regulate splicing events, trigger degradation, or interfere with protein translation. The World Health Organization reported in September 2022, for example, that out of 41 million deaths globally caused by non-communicable diseases (NCDs) or chronic diseases, amounting to 74% of total annual deaths. Of these, 17.9 million were due to cardiovascular diseases, 9.3 million to cancer, 4.1 million to chronic respiratory illnesses, and 2.0 million to diabetes. Hence, the increase in chronic and rare diseases is propelling the oligonucleotide synthesis market's expansion.

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Which Fast-Growing Trends Are Poised to Disrupt the Oligonucleotide Synthesis Market?
The main trend making waves in the oligonucleotide synthesis market is product innovation. To maintain their market standing, top firms are creating groundbreaking products. For instance, Ansa Biotechnologies, Inc., a U.S. company that specializes in complex DNA production, unveiled Ansa Clonal DNA and Ansa DNA Fragments in July 2024. Ansa Clonal DNA delivers clonal, flawless DNA sequences up to 600 base pairs long. This eliminates the necessity of assembly and offers unparalleled precision for intricate synthetic biology tasks. This product delivers error-free, ready-to-use DNA sequences, which makes it a trustworthy option for researchers. Ansa DNA Fragments provides sequence-checked linear double-stranded DNA fragments, also a maximum of 600 base pairs, adjusted for multiple research applications. Ansa employs an inventive enzymatic synthesis procedure to consistently generate intricate DNA constructs, inclusive of repeats and secondary structures, with high accuracy.

What Are the Emerging Segments in the Oligonucleotide Synthesis Market?
The oligonucleotide synthesis market covered in this report is segmented -

1) By Type: Custom Oligos, Predesigned Oligos
2) By Product Type: Oligonucleotides, Reagents, Equipment, Services, Purification, Modification
3) By Application: Therapeutic Applications, Research Applications, Diagnostic Applications

Subsegments:
1) By Custom Oligos: Long Oligonucleotides, Short Oligonucleotides, Modified Oligonucleotides
2) By Predesigned Oligos: Gene-Specific Oligos, Probe Oligos, Primers For PCR And RT-PCR

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Who Are the Global Leaders in the Oligonucleotide Synthesis Market?
Major companies operating in the oligonucleotide synthesis market include Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, GE HealthCare Technologies Inc., Eurofins Scientific SE, Agilent Technologies Inc., Nitto Denko Avecia Inc., Alnylam Pharmaceuticals Inc., Maravai Life Sciences, LGC Limited, Ionis Pharmaceuticals Inc., GenScript Inc., Ajinomoto Bio-Pharma Services, Sarepta Therapeutics Inc., Integrated DNA Technologies Inc., Twist Bioscience Corporation, Eurogentec SA, Kaneka Eurogentec S.A., Biocomma Limited, Bio-Synthesis Inc., TriLink BioTechnologies Incorporated, Generi Biotech s.r.o., ATDBio Ltd., BioAutomation Corporation, Biolegio B.V., Dharmacon Research Inc.

Which are the Top Profitable Regional Markets for the Oligonucleotide Synthesis Industry?
North America was the largest region in the oligonucleotide synthesis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the oligonucleotide synthesis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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