Bronchiolitis Obliterans Syndrome - Pipeline Insight, 2025: Innovative Immunomodulatory and Antifibrotic Therapies Aim to Transform Long-Term Transplant Outcomes | DelveInsight

Bronchiolitis Obliterans Syndrome (BOS), a chronic and often irreversible manifestation of lung transplant rejection, remains a leading cause of morbidity and mortality in post-transplant patients. Characterized by progressive small airway inflammation and fibrosis, BOS significantly limits long-term graft survival despite advances in immunosuppressive regimens.

As of 2025, the BOS treatment pipeline is gaining renewed momentum, with over 3 assets under various stages of development. These include emerging antifibrotic agents, immune-targeting biologics, mesenchymal stem cell-based approaches, and inhalation therapies tailored to arrest airway remodeling. Notable companies such as Breath Therapeutics, SCM Lifescience, and OrphAI Therapeutics are advancing candidates that hold potential to shift the clinical trajectory of BOS from symptomatic control to disease modification.

DelveInsight's "Bronchiolitis Obliterans Syndrome - Pipeline Insight, 2025" provides an in-depth analysis of the investigational landscape, tracking key molecules, clinical timelines, strategic collaborations, and novel MoAs designed to prolong graft survival and reduce chronic rejection risk.

With the promise of next-generation immunomodulators and organ-specific regenerative approaches, the BOS pipeline may soon redefine standards of care, improving post-transplant quality of life and long-term outcomes.

Interested in learning more about the current treatment landscape and the key drivers shaping the Bronchiolitis Obliterans Syndrome pipeline? Click here: https://www.delveinsight.com/report-store/bronchiolitis-obliterans-syndrome-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Key Takeaways from the Bronchiolitis Obliterans Syndrome Pipeline Report
• DelveInsight's bronchiolitis obliterans syndrome pipeline analysis depicts a strong space with 3+ active players working to develop 3+ pipeline drugs for bronchiolitis obliterans syndrome treatment.
• The leading bronchiolitis obliterans syndrome companies include Breath Therapeutics, SCM Lifescience, OrphAI Therapeutics, and others are evaluating their lead assets to improve the bronchiolitis obliterans syndrome treatment landscape.
• Key bronchiolitis obliterans syndrome pipeline therapies in various stages of development include Liposomal Cyclosporine A, SCM-CGH, LAM-001, and others.
• In January 2024, Renovion completed enrollment for its Phase II CLIMB trial, which evaluated ARINA-1 in adults with non-CF bronchiectasis. This U.S.-based, randomized, double-blind, placebo-controlled study aimed to assess the safety, tolerability, and effectiveness of ARINA-1. The trial's primary goals included measuring its impact on quality of life, sputum properties, blood inflammatory markers, and other exploratory clinical outcomes in bronchiectasis patients.
• In March 2023, the FDA granted Fast Track designation to Renovion's nebulized ARINA‐1, developed to prevent BOS progression in adults after bilateral lung transplants. This status enables rolling submissions and faster review, addressing the high mortality rate (~45% within 5 years post-transplant) and the current lack of approved BOS treatments.

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Bronchiolitis Obliterans Syndrome Overview
Bronchiolitis Obliterans Syndrome (BOS) is a rare, chronic, and progressive lung condition that commonly occurs as a serious complication following lung transplantation or allogeneic hematopoietic stem cell transplantation (HSCT). Characterized by inflammation and fibrotic narrowing of the small airways (bronchioles), BOS leads to irreversible airflow obstruction, declining lung function, and respiratory failure. Clinically, it presents with symptoms such as persistent cough, shortness of breath, and wheezing, often mimicking chronic obstructive pulmonary disease (COPD). Diagnosis relies on pulmonary function tests showing a sustained drop in FEV1 and radiological findings, as biopsies are rarely performed due to procedural risk.

Currently, there are no FDA-approved therapies for BOS, and treatment is primarily supportive, focusing on immunosuppression, anti-inflammatory agents like azithromycin, and symptom management. However, recent advances in research have spurred the development of promising pipeline candidates, including inhaled liposomal cyclosporine A, ARINA-1, ruxolitinib, and belumosudil. These therapies aim to address the underlying immune mechanisms and fibrotic pathways of BOS, offering hope for improved outcomes in this underserved patient population.

Find out more about Bronchiolitis Obliterans Syndrome medication at https://www.delveinsight.com/report-store/bronchiolitis-obliterans-syndrome-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Bronchiolitis Obliterans Syndrome Treatment Analysis: Drug Profile
Liposomal Cyclosporine A: Zambon Company
Liposomal Cyclosporine A for Inhalation (L-CsA-i), developed by Zambon Company, is an innovative liposomal formulation of cyclosporine A specifically designed for inhaled delivery to the lungs. As a calcineurin inhibitor (CNI), cyclosporine A is a powerful immunosuppressant widely used in lung transplantation. L-CsA-i is administered using a dedicated Investigational eFlow® Technology nebulizer system from PARI Pharma GmbH, ensuring targeted delivery to the affected lung tissue. This drug-device combination is currently in Phase III clinical development for the treatment of Bronchiolitis Obliterans Syndrome (BOS), aiming to provide localized immunosuppression directly at the site of disease.

Learn more about the novel and emerging Bronchiolitis Obliterans Syndrome pipeline therapies at https://www.delveinsight.com/report-store/bronchiolitis-obliterans-syndrome-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Bronchiolitis Obliterans Syndrome Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Intravenous
• Subcutaneous
• Oral
• Intramuscular

By Molecule Type
• Monoclonal antibody
• Small molecule
• Peptide

Scope of the Bronchiolitis Obliterans Syndrome Pipeline Report
• Coverage: Global
• Key Bronchiolitis Obliterans Syndrome Companies: Breath Therapeutics, SCM Lifescience, OrphAI Therapeutics, and others.
• Key Bronchiolitis Obliterans Syndrome Pipeline Therapies: Liposomal Cyclosporine A, SCM-CGH, LAM-001, and others.

Dive deep into rich insights for drugs used for Bronchiolitis Obliterans Syndrome treatment, visit: https://www.delveinsight.com/report-store/bronchiolitis-obliterans-syndrome-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Table of Contents
1. Introduction
2. Executive Summary
3. Bronchiolitis Obliterans Syndrome Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Bronchiolitis Obliterans Syndrome Pipeline Therapeutics
6. Bronchiolitis Obliterans Syndrome Pipeline: Late-Stage Products (Phase III)
7. Bronchiolitis Obliterans Syndrome Pipeline: Mid-Stage Products (Phase II)
8. Bronchiolitis Obliterans Syndrome Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

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This release was published on openPR.