Mastocytosis Clinical Trials Appears Robust With 10+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

DelveInsight's, "Mastocytosis Pipeline Insight 2025" report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Mastocytosis pipeline landscape. It covers the Mastocytosis pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Mastocytosis Pipeline Report
• In April 2025, Blueprint Medicines Corporation announced a study is to evaluate the long-term safety of avapritinib in participants who have completed a Blueprint Medicines sponsored study (parent study) and continued to benefit from avapritinib.
• DelveInsight's Mastocytosis pipeline report depicts a robust space with 10+ active players working to develop 10+ pipeline therapies for Mastocytosis treatment.
• The leading Mastocytosis Companies such as Cogent Biosciences, Deciphera Pharmaceuticals, AB Science, Pfizer, Novelty Nobility, Blueprint Medicines and others.
• Promising Mastocytosis Pipeline Therapies such as PA101, Masitinib, RAD001 (Everolimus), TF 002, Avapritinib, Elenestinib, Brentuximab vedotin and others.

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Mastocytosis Emerging Drugs Profile
• Masitinib: AB Science
Masitinib is an orally administered tyrosine kinase inhibitor. It modulates the activity of mast cells and macrophages, important cells for immunity, through targeting a limited number of kinases without inhibiting, at therapeutic doses, kinases associated with known toxicities. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology, masitinib has the potential to improve survival when administered alone or in combination with chemotherapy via targeting of specific gene mutations or because of its immunotherapeutic properties. Masitinib can exert a neuroprotective effect in some central nervous system diseases and reduce symptoms in some chronic inflammatory disorders through its activity on mast cells and microglia, with subsequent modulation of inflammatory and neurodegenerative processes.

• Ripretinib: Deciphera Pharmaceuticals
Ripretinib is a switch-control tyrosine kinase inhibitor that was engineered to broadly inhibit KIT mutated kinases by using a dual mechanism of action that regulates the kinase switch pocket and activation loop1 and 2.

The Mastocytosis Pipeline Report Provides Insights into
• The report provides detailed insights about companies that are developing therapies for the treatment of Mastocytosis with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Mastocytosis Treatment.
• Mastocytosis Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Mastocytosis Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the C Mastocytosis market

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Mastocytosis Companies
Cogent Biosciences, Deciphera Pharmaceuticals, AB Science, Pfizer, Novelty Nobility, Blueprint Medicines and others.

Mastocytosis Pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Oral
• Intravenous
• Subcutaneous

Mastocytosis Products have been categorized under various Molecule types such as
• Small molecule
• Cell Therapy
• Peptides
• Polymer
• Small molecule
• Gene therapy

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Scope of the Mastocytosis Pipeline Report
• Coverage- Global
• Mastocytosis Companies- Cogent Biosciences, Deciphera Pharmaceuticals, AB Science, Pfizer, Novelty Nobility, Blueprint Medicines and others.
• Mastocytosis Pipeline Therapies- PA101, Masitinib, RAD001 (Everolimus), TF 002, Avapritinib, Elenestinib, Brentuximab vedotin and others.
• Mastocytosis Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Mastocytosis Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Content
1. Introduction
2. Executive Summary
3. Mastocytosis: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Mastocytosis- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Masitinib: AB Science
9. Drug profiles in the detailed report.....
10. Mid Stage Products (Phase II)
11. Bezuclastinib: Cogent Biosciences
12. Drug profiles in the detailed report.....
13. Early Stage Products (Phase I)
14. Ripretinib: Deciphera Pharmaceuticals
15. Drug profiles in the detailed report.....
16. Preclinical Stage Products
17. Crenolanib: Pfizer
18. Drug profiles in the detailed report.....
19. Inactive Products
20. Mastocytosis Key Companies
21. Mastocytosis Key Products
22. Mastocytosis- Unmet Needs
23. Mastocytosis- Market Drivers and Barriers
24. Mastocytosis- Future Perspectives and Conclusion
25. Mastocytosis Analyst Views
26. Mastocytosis Key Companies
27. Appendix

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