Oligonucleotide Therapy Market Expansion Till 2031: Japan Updates Indicate Strategic R&D Investments

Oligonucleotide Therapy Market size was valued at USD 4,207.20 million in 2021 and is estimated to reach at a compound annual growth rate (CAGR) of 15.80% over the forecast period 2024-2031.

Latest Key Developments:

Patent granted for KIT-targeting splice-switching therapy

Hoth Therapeutics secured a Japanese patent (No. 7677628) on May 7, 2025, covering its splice-switching oligonucleotide (SSO) platform aimed at inhibiting KIT gene expression in mast-cell diseases. This protection lasts until August 27, 2039

Orphan Drug status awarded in Japan for DM1 treatment

Avidity Biosciences' antibody-oligonucleotide conjugate delpacibart‐etedesiran (del‐desiran) received Orphan Drug designation from Japan's Ministry of Health, Labour and Welfare on April 8, 2025. It's the first investigational DM1 therapy to earn this in Japan

Enhanced ASO delivery breakthrough by Tokyo University team

Researchers at Tokyo University of Science, collaborating with Takeda, published a February 18, 2025, study on cholesterol‐conjugated heteroduplex oligonucleotides (Chol‐HDOs). These show significantly improved stability, blood retention, and brain penetration compared to traditional ASOs

Fujifilm validates peptide‐oligo conjugates for precise cancer targeting

On May 19, 2025, FUJIFILM announced successful validation of peptide-oligonucleotide conjugates that use cyclic peptides to enhance selective uptake into cancer cells. This work was highlighted at TIDES USA 2025

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Oligonucleotide Therapy Market Overview

Oligonucleotide therapy involves short DNA or RNA molecules designed to alter gene expression for treating diseases such as cancer, genetic disorders, and viral infections. These therapies offer high specificity and targeted action at the molecular level.

Research Methodology:

The global Oligonucleotide Therapy Market research report is based on a combination of primary and secondary data sources. The study carefully analyzes various factors influencing the industry, including government regulations, market dynamics, competitive landscape, historical trends, current conditions, and technological progress. It also evaluates future developments, related industry trends, market volatility, growth prospects, potential obstacles, and emerging challenges.

Segment Covered in the Oligonucleotide Therapy Market:

By Type (Antisense Oligonucleotide, Aptamer, Other

By Application: Infectious Diseases, Oncology, Neurodegenerative Disorders, Cardiovascular Diseases, Kidney Diseases, Others

By End User: Hospitals, Research Institutes

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List of the Key Players in the Oligonucleotide Therapy Market:

Kastle Therapeutics, Sarepta Therapeutics, Pfizer Inc., InteRNA Technologies B.V., Santaris, Akcea Therapeutics, Miragen Therapeuutics Inc., Alnylam Pharmaceuticals Inc.,, Biogen Inc., Ionis Pharmaceuticals Inc.

Regional Analysis for Oligonucleotide Therapy Market:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

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The Report Includes:

➡ A descriptive analysis of demand-supply gap, market size estimation, SWOT analysis, PESTEL Analysis and forecast in the global market.

➡ Top-down and bottom-up approach for regional analysis

➡ Go-to-market Strategy.

➡ Neutral perspective on the market performance.

➡ Customized regional/country reports as per request and country level analysis.

➡ Potential & niche segments and regions exhibiting promising growth covered.

People Also Ask:

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