Cognitive Impairment Associated with Schizophrenia Market to Expand Significantly by 2034, Driven by Boehringer Ingelheim, Recognify Life Sciences, Alto Neuroscience, and Kynexis | DelveInsight

Cognitive Impairment Associated with Schizophrenia (CIAS) is a core and debilitating feature of schizophrenia, significantly impacting daily functioning, social interactions, and overall quality of life. Despite being a major contributor to long-term disability in affected individuals, CIAS remains a largely unmet medical need, with no FDA-approved treatments specifically targeting cognitive deficits.

DelveInsight's latest report, "Cognitive Impairment Associated with Schizophrenia - Market Insight, Epidemiology, and Market Forecast - 2034," provides a comprehensive analysis of the evolving CIAS landscape across key markets, including the US, EU4 (Germany, France, Italy, Spain), the UK, and Japan. The report features detailed epidemiological segmentation by disease severity, age, and treatment status, along with historical and forecasted trends.

The current therapeutic landscape for schizophrenia primarily focuses on managing psychotic symptoms, while cognitive deficits often remain unaddressed. However, increasing awareness of CIAS as a distinct and impactful clinical domain is driving new research efforts and therapeutic development. Pharmaceutical companies are actively exploring glutamatergic modulators, muscarinic agonists, and nicotinic receptor agents to fill this gap.

The CIAS market is expected to expand steadily through 2034, fueled by advances in neuroscience, improved diagnostic frameworks, growing clinical recognition of cognitive symptoms, and rising R&D investments. Emerging therapies targeting neurobiological pathways linked to cognition are showing promise in clinical trials, potentially paving the way for disease-modifying treatments.

DelveInsight anticipates a transformative decade ahead for the CIAS market, with increasing momentum among drug developers, healthcare providers, and policymakers to address this critical unmet need. With breakthroughs on the horizon, the CIAS market is poised to deliver meaningful improvements in patient outcomes and redefine therapeutic standards for schizophrenia care.

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Some of the key insights of the Cognitive Impairment Associated with Schizophrenia Market Report:
• The cognitive impairment associated with schizophrenia market in the 7MM was valued at ~USD 948 million in 2023 and is expected to grow at a CAGR of 8.9% from 2024 to 2034.
• In 2023, there were ~3 million diagnosed CIAS cases in the 7MM.
• The U.S. accounted for ~USD 706.2 million of the market and ~1.5 million diagnosed cases, both projected to increase by 2034.
• The EU4 and UK market was ~USD 180.5 million in 2023, representing ~19% of the 7MM total.
• Boehringer Ingelheim's iclepertin (BI-425809), a Phase III candidate, is expected to launch by 2026.
• In January 2025, Boehringer Ingelheim reported that its Phase III CONNEX trials for iclepertin in CIAS failed to meet primary or key secondary endpoints, showing no significant cognitive or functional improvements. However, the drug was well tolerated with a consistent safety profile.
• In December 2024, Kynexis announced positive topline results from a Phase I trial of KYN-5356, a first-in-class oral KAT-II inhibitor for CIAS. The study confirmed safety, tolerability, and target engagement through pharmacodynamic biomarkers and cognitive assessments.
• In September 2024, Neurocrine Biosciences reported that its Phase II ERUDITETM trial for luvadaxistat in CIAS did not meet its primary endpoint, following a similar outcome in the earlier INTERACTTM study. Variability in cognitive assessments and baseline imbalances may have influenced results.
• Emerging therapies for cognitive impairment associated with schizophrenia include Iclepertin (BI-425809), RL-007, ALTO-101, KYN-5356, GT-002, and others.
• Key companies involved in the treatment of cognitive impairment associated with schizophrenia include Boehringer Ingelheim, Recognify Life Sciences, Alto Neuroscience/MEDRx, Kynexis, Gabather AB, and others.

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Cognitive Impairment Associated with Schizophrenia Overview
Cognitive Impairment Associated with Schizophrenia (CIAS) is a core and persistent feature of schizophrenia, affecting various domains such as attention, memory, executive function, and processing speed. Unlike hallucinations or delusions, these cognitive deficits often appear early, sometimes even before the first psychotic episode, and typically remain stable throughout the illness. CIAS severely impacts a patient's ability to function independently, maintain employment, and engage in social interactions, making it a major contributor to long-term disability in schizophrenia.

Currently, there are no FDA-approved treatments specifically targeting CIAS, and standard antipsychotic medications offer limited to no cognitive benefit. The pathophysiology behind CIAS is multifactorial, involving disruptions in glutamatergic, cholinergic, and dopaminergic signaling, as well as altered neuroplasticity and neuroinflammation. Ongoing research is focused on novel therapeutic approaches, including muscarinic receptor agonists, NMDA modulators, and nicotinic agents, aiming to address the substantial unmet need in this area and improve functional outcomes for affected individuals.

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Cognitive Impairment Associated with Schizophrenia Epidemiology
The epidemiology section offers an overview of historical, current, and projected trends in the seven major countries (7MM) from 2020 to 2034. It helps identify the factors influencing these trends by examining various studies and perspectives from key opinion leaders. Additionally, the section provides an in-depth analysis of the diagnosed patient population and future trends.

Cognitive Impairment Associated with Schizophrenia Epidemiology Segmentation:
The cognitive impairment associated with schizophrenia market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM, segmented into:
• Total Prevalent Cases of Schizophrenia
• Total Diagnosed Prevalent Cases of Schizophrenia
• Total Diagnosed Prevalent Cases of CIAS
• Gender-Specific Diagnosed Prevalent Cases of Schizophrenia

Cognitive Impairment Associated with Schizophrenia Drugs Uptake and Pipeline Development Activities
The Drug Uptake section offers a detailed analysis of the adoption trends of newly launched and upcoming therapies for Cognitive Impairment Associated with Schizophrenia throughout the study period. It evaluates patient adoption rates, market penetration, and the commercial performance of each therapy, providing a clear understanding of the factors driving or hindering the market acceptance of these treatments.

The Therapeutics Assessment further highlights the Cognitive Impairment Associated with Schizophrenia drugs, demonstrating the most rapid uptake. It examines the underlying drivers contributing to their swift adoption and compares the market share of these therapies to identify those gaining significant traction.

Additionally, the report provides an in-depth overview of the current therapeutic pipeline for Cognitive Impairment Associated with Schizophrenia, covering investigational drugs at various stages of development. It profiles the key pharmaceutical and biotech companies actively involved in advancing targeted treatments and presents the latest updates on partnerships, mergers and acquisitions, licensing deals, and other strategic developments shaping the future of Cognitive Impairment Associated with Schizophrenia therapeutics.

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Cognitive Impairment Associated with Schizophrenia Market Outlook
The market outlook for Cognitive Impairment Associated with Schizophrenia (CIAS) reflects a high unmet medical need, as current treatments primarily manage symptoms without effectively targeting the core cognitive deficits. While interest in developing disease-modifying therapies is growing, the development pipeline remains relatively limited, with only a few promising candidates such as iclepertin, RL-007, and ALTO-101 in clinical trials. These investigational therapies aim to improve cognitive function by targeting underlying neurobiological mechanisms rather than relying on conventional antipsychotic approaches.

As awareness of CIAS and its impact on long-term functional outcomes increases, the market is expected to witness gradual expansion driven by advancements in neuroscience, biomarker research, and precision psychiatry. However, significant challenges remain, including the complexity of cognitive symptoms, variability in clinical presentation, and the need for standardized assessment tools. The success of novel therapies in late-stage development will be crucial in reshaping the CIAS treatment landscape and opening new opportunities for innovation and investment in this underserved segment.

Cognitive Impairment Associated with Schizophrenia Market Drivers
• Increasing recognition of the role cognitive deficits play in determining long-term outcomes for individuals with schizophrenia is driving interest in developing CIAS-specific therapies. As cognitive impairment affects daily living, employment, and social integration, stakeholders are focusing more on addressing this core symptom domain.
• Breakthroughs in understanding the neurobiology of schizophrenia, particularly regarding neurotransmitter systems like glutamate, GABA, and cholinergic pathways, are fueling the development of targeted treatments for CIAS. The emergence of precision psychiatry and biomarker-based approaches also supports innovation in this niche market.

Cognitive Impairment Associated with Schizophrenia Market Barriers
• Despite the pressing need, there are currently no approved drugs specifically for CIAS, and the development pipeline remains sparse. Few agents, such as iclepertin and RL-007, are in advanced stages, reflecting the scientific and regulatory complexity of bringing CIAS therapies to market.
• Measuring cognitive impairment in schizophrenia reliably remains a hurdle. The absence of standardized cognitive endpoints, interpatient variability, and the difficulty in isolating cognitive symptoms from other schizophrenia domains complicate clinical trial design and data interpretation, slowing drug development efforts.

Scope of the Cognitive Impairment Associated with Schizophrenia Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan].
• Key Cognitive Impairment Associated with Schizophrenia Companies: Boehringer Ingelheim, Recognify Life Sciences, Alto Neuroscience/MEDRx, Kynexis, Gabather AB, and others.
• Key Cognitive Impairment Associated with Schizophrenia Therapies: Iclepertin (BI-425809), RL-007, ALTO-101, KYN-5356, GT-002, and others.
• Cognitive Impairment Associated with Schizophrenia Therapeutic Assessment: Cognitive Impairment Associated with Schizophrenia, currently marketed, and Cognitive Impairment Associated with Schizophrenia emerging therapies.
• Cognitive Impairment Associated with Schizophrenia Market Dynamics: Cognitive Impairment Associated with Schizophrenia market drivers and Cognitive Impairment Associated with Schizophrenia market barriers.
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies.
• Cognitive Impairment Associated with Schizophrenia Unmet Needs, KOL's views, Analyst's views, Cognitive Impairment Associated with Schizophrenia Market Access and Reimbursement.

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Table of Contents
1. Cognitive Impairment Associated with Schizophrenia Market Report Introduction
2. Executive Summary for Cognitive Impairment Associated with Schizophrenia
3. SWOT Analysis of Cognitive Impairment Associated with Schizophrenia
4. Cognitive Impairment Associated with Schizophrenia Patient Share (%) Overview at a Glance
5. Cognitive Impairment Associated with Schizophrenia Market Overview at a Glance
6. Cognitive Impairment Associated with Schizophrenia Disease Background and Overview
7. Cognitive Impairment Associated with Schizophrenia Epidemiology and Patient Population
8. Country-Specific Patient Population of Cognitive Impairment Associated with Schizophrenia
9. Cognitive Impairment Associated with Schizophrenia Current Treatment and Medical Practices
10. Cognitive Impairment Associated with Schizophrenia Unmet Needs
11. Cognitive Impairment Associated with Schizophrenia Emerging Therapies
12. Cognitive Impairment Associated with Schizophrenia Market Outlook
13. Country-Wise Cognitive Impairment Associated with Schizophrenia Market Analysis (2020-2034)
14. Cognitive Impairment Associated with Schizophrenia Market Access and Reimbursement of Therapies
15. Cognitive Impairment Associated with Schizophrenia Market Drivers
16. Cognitive Impairment Associated with Schizophrenia Market Barriers
17. Cognitive Impairment Associated with Schizophrenia Appendix
18. Cognitive Impairment Associated with Schizophrenia Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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This release was published on openPR.