Antibody Drug Conjugates Market Set for Robust Growth Through 2034 - Market Size, Target Population, Competitive Landscape & Forecast | DelveInsight

The Antibody Drug Conjugates (ADCs) market is poised for exceptional growth through 2034, fueled by a wave of innovation, an expanding oncology pipeline, and increasing demand for targeted cancer therapies. ADCs, highly potent biopharmaceuticals that deliver cytotoxic agents directly to cancer cells, are transforming the oncology treatment paradigm by improving efficacy while limiting off-target toxicity.

DelveInsight's comprehensive report, "Antibody Drug Conjugates Market Size, Target Population, Competitive Landscape & Market Forecast - 2034," provides a deep dive into the global ADC landscape, covering the US, EU4 (Germany, France, Italy, Spain), the UK, Japan, and other major markets. The report offers detailed analyses of target patient populations across oncology and non-oncology indications, evolving clinical pipelines, market dynamics, and competitive positioning.

The ADC market has gained strong momentum, supported by several successful product launches in breast, lung, hematologic, and urothelial cancers. Recent approvals of next-generation ADCs with optimized linkers and novel payloads, such as HER2-directed agents and TROP2-targeting conjugates, have expanded therapeutic options and significantly enhanced patient outcomes.

The global ADC market size is projected to witness double-digit growth through 2034, driven by expanding indications, improved design technologies, favorable reimbursement, and rising prevalence of hard-to-treat cancers. In parallel, emerging partnerships and licensing deals are intensifying competition, creating opportunities for both large pharma and innovative biotech companies.

As next-generation ADCs targeting novel antigens and leveraging advanced conjugation techniques enter the market, DelveInsight anticipates a transformative decade for this segment. ADCs are expected to become central to precision oncology, driving significant clinical and commercial value across global markets.

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Some of the key insights of the Antibody Drug Conjugates Market Report:
• In 2023, the antibody drug conjugates market size across the 7MM was approximately USD 259 million, expected to grow significantly by 2034.
• The FDA approved 13 ADCs, with MYLOTARG being the first. It was withdrawn in 2017 after trials failed to show benefit and raised safety concerns.
• In 2023, ENHERTU generated approximately USD 1,470 million in U.S. sales, while KADCYLA accounted for about USD 760 million in U.S. revenue.
• In 2023, Breast Cancer had approximately 300K incident cases in the US and was one of the primary indications for Antibody Drug Conjugates (ADCs), due to the ongoing need for targeted therapies.
• Lung Cancer accounted for around 200K incident cases in the US in 2023, with ADCs playing a significant role in targeted treatment options, especially for specific subtypes.
• Ovarian Cancer was expected to have about 20K incident cases in the US in 2023, and ADCs emerged as a focus in clinical development for this indication, aiming to improve outcomes.
• Diffuse Large B-Cell Lymphoma (DLBCL) had approximately 31K incident cases in the US in 2023. ADCs gained traction as promising therapies for this type of hematologic malignancy.
• Multiple Myeloma was projected to have 37K incident cases in the US in 2023, with ADCs playing an increasingly important role in advancing treatment options for patients with this malignancy.
• In March 2025, Moderna, Inc. (NASDAQ: MRNA) announced that Australia's Therapeutic Goods Administration (TGA) approved mRESVIA® (mRNA-1345), an mRNA vaccine for preventing lower respiratory tract disease caused by RSV in adults aged 60 and older. This approval marks the first mRNA vaccine in Australia authorized for a disease other than COVID-19.
• In February 2025, Moderna, Inc. (NASDAQ: MRNA) announced that the UK's Medicines and Healthcare products Regulatory Agency (MHRA) granted marketing authorization for mRESVIA (mRNA-1345) for the prevention of RSV-related lower respiratory tract disease (LRTD) in adults aged 60 and above.
• In March 2025, Radiance Biopharma announced that the U.S. Food and Drug Administration (FDA) cleared its Investigational New Drug (IND) application for RB-164TM, an ROR-1 targeted Antibody Drug Conjugate (ADC) for hematologic and solid malignancies.
• Emerging therapies for antibody drug conjugates include Telisotuzumab vedotin, Patritumab deruxtecan, Ifinatamab deruxtecan, ARX788, AZD8205, Raludotatug deruxtecan, Farletuzumab ecteribulin, and others.
• Key companies involved in the treatment of antibody drug conjugates include pyxis Oncology, Vincerx Pharma, Sutro Biopharma, Byondis, OBI Pharma, NBE-Therapeutics, Shanghai Miracogen Inc., Daiichi Sankyo, ADC Therapeutics, and others.

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Antibody Drug Conjugates Overview
Antibody-drug conjugates (ADCs) represent an emerging class of highly potent therapeutics that combine the precision of immunotherapy with the cancer-killing power of chemotherapy. ADCs enable targeted delivery of cytotoxic agents directly to tumor cells, sparing healthy tissues and minimizing the systemic toxicity often associated with conventional chemotherapy, thus offering a wider therapeutic window.

A critical factor in developing effective ADCs is selecting an optimal antigenic target for the monoclonal antibody component. The ideal target antigen must meet several key criteria: it should be highly expressed on tumor cells but absent or minimally present on healthy cells; it must be located on the surface of tumor cells to ensure accessibility to the circulating antibody; and it should promote internalization of the ADC, allowing efficient delivery of the cytotoxic payload into cancer cells and maximizing therapeutic impact.

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Antibody Drug Conjugates Epidemiology
The epidemiology section offers an overview of historical, current, and projected trends in the seven major countries (7MM) from 2020 to 2034. It helps identify the factors influencing these trends by examining various studies and perspectives from key opinion leaders. Additionally, the section provides an in-depth analysis of the diagnosed patient population and future trends.

Antibody Drug Conjugates Epidemiology Segmentation:
The Antibody Drug Conjugates market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM, segmented into:
• Total incident cases of potential indications (Non-small Cell Lung Cancer, Hematologic malignancies [such as PTCL, CTCL, DLBCL, and others], Breast Cancer, Gynecologic cancer, and others)
• Total indication-wise eligible cases
• Indication-wise treatable cases.

Antibody Drug Conjugates, Drug Uptake, and Pipeline Development Activities
The Drug Uptake section offers a detailed analysis of the adoption trends of newly launched and upcoming therapies for antibody drug conjugates throughout the study period. It evaluates patient adoption rates, market penetration, and the commercial performance of each therapy, providing a clear understanding of the factors driving or hindering the market acceptance of these treatments.

The Therapeutics Assessment further highlights the antibody drug conjugate drugs, demonstrating the most rapid uptake. It examines the underlying drivers contributing to their swift adoption and compares the market share of these therapies to identify those gaining significant traction.

Additionally, the report provides an in-depth overview of the current therapeutic pipeline for antibody drug conjugates, covering investigational drugs at various stages of development. It profiles the key pharmaceutical and biotech companies actively involved in advancing targeted treatments and presents the latest updates on partnerships, mergers and acquisitions, licensing deals, and other strategic developments shaping the future of antibody drug conjugate therapeutics.

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Antibody Drug Conjugates Market Outlook
The advent of antibody-drug conjugates (ADCs) is transforming the treatment landscape for solid tumors, most notably in HER2-positive breast cancer, by delaying disease progression and extending survival in this aggressive subtype. The remarkable success of ADCs like ENHERTU is now driving broader exploration across various cancer types that express diverse tumor antigens, promising to reshape treatment paradigms across oncology.

ENHERTU's growing market penetration and expanding indications are fueling a steady rise in sales. Data from the DESTINY-Breast06 trial, presented at ASCO 2024, may allow ENHERTU to move into earlier treatment lines for HER2-low breast cancer and potentially target patients with even lower HER2 expression.

Similarly, TRODELVY has emerged as the first ADC to demonstrate an overall survival benefit and has shown efficacy in HR+/HER2- breast cancer, the most prevalent subtype. Innovations in linker chemistry, antibody engineering, and potent payloads are now enabling ADCs to target tumors with varying antigen expression, expanding their reach, but these advancements also bring new toxicities that require vigilant patient monitoring.

Looking ahead, the ADC market is poised for dynamic growth as pharmaceutical companies pursue aggressive development programs across a wide range of indications during the 2024-2034 forecast period. With over 200 ADC candidates currently in preclinical or clinical stages, the field is entering a new era of precision oncology. While Roche presently leads the market, Daiichi Sankyo is expected to emerge as a major force in the next wave of ADC innovation.

Antibody Drug Conjugates Market Drivers
• Improved ADC design, including stable linkers, potent payloads, and specific antibodies, enhances efficacy and safety, driving oncology adoption.
• Increasing cancer cases and limitations of traditional therapies fuel demand for targeted ADCs, addressing unmet needs.

Antibody Drug Conjugates Market Barriers
• Complex ADC development and manufacturing processes lead to elevated costs, limiting affordability and access.
• Stringent regulations and potential toxicities require rigorous safety validation, delaying approvals and increasing risks.

Scope of the Antibody Drug Conjugates Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan].
• Key Antibody Drug Conjugates Companies: Pyxis Oncology, Vincerx Pharma, Sutro Biopharma, Byondis, OBI Pharma, NBE-Therapeutics, Shanghai Miracogen Inc., Daiichi Sankyo, ADC Therapeutics, and others.
• Key Antibody Drug Conjugates Therapies: Telisotuzumab vedotin, Patritumab deruxtecan, Ifinatamab deruxtecan, ARX788, AZD8205, Raludotatug deruxtecan, Farletuzumab ecteribulin, and others.
• Antibody Drug Conjugates Therapeutic Assessment: Antibody Drug Conjugates currently marketed, and Antibody Drug Conjugates emerging therapies.
• Antibody Drug Conjugates Market Dynamics: Antibody Drug Conjugates market drivers and Antibody Drug Conjugates market barriers.
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies.
• Antibody Drug Conjugates Unmet Needs, KOL's views, Analyst's views, Antibody Drug Conjugates Market Access and Reimbursement.

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Table of Contents
1. Key Insights
2. Report Introduction
3. Executive Summary of Antibody Drug Conjugates (ADC)
4. Key Events
5. Antibody Drug Conjugates (ADC) Market Overview
6. Background And Overview
7. Target Population
8. Antibody Drug Conjugates (ADC) Marketed Drugs
9. Antibody Drug Conjugates (ADC) Emerging Drugs
10. Antibody Drug Conjugates (ADC): The 7MM Analysis
11. Unmet Needs
12. SWOT Analysis
13. KOL Views
14. Market Access and Reimbursement
15. Appendix

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This release was published on openPR.