Continuous Renal Replacement Therapy Market: Global Insights, Competitive Landscape, and Forecast to 2032 | DelveInsight

The continuous renal replacement therapy market is witnessing robust growth, driven by factors such as the rising prevalence of acute kidney injury (AKI) and chronic kidney diseases, increasing ICU admissions, and advancements in CRRT machine technologies. Enhanced device features, including improved precision, portability, and automation, are boosting the adoption of CRRT machines in critical care settings. These factors are expected to fuel steady expansion of the continuous renal replacement therapy market through 2030.

DelveInsight's Continuous Renal Replacement Therapy Market Insights report delivers comprehensive market analysis, competitive landscape, key market drivers and challenges, and detailed profiles of leading CRRT machine manufacturers.

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Key Takeaways from the Continuous Renal Replacement Therapy Machines Market Report
• The CRRT machines market was valued at USD 1.17 billion in 2023 and is projected to reach USD 1.78 billion by 2032, growing at a CAGR of 7.38%.
• As per DelveInsight estimates, North America is anticipated to dominate the global continuous renal replacement therapy market during the forecast period.
• Notable continuous renal replacement therapy companies such as Baxter, Fresenius Medical Care AG, NIKKISO CO., LTD, B.Braun Melsungen AG, Asahi Kasei Corporation, Infomed SA, Medtronic, NxStage Medical, Inc., Medica S.p.A., SWS Hemodialysis Care Co., Ltd, Dialco Medical Inc, Anjue Medical Equipment, Medica S.p.A., Jiangxi Sanxin Medtec, and several others are currently operating in the continuous renal replacement therapy market.
• In April 2025, SeaStar Medical Holding Corporation (Nasdaq: ICU) announced that the FDA granted two new Breakthrough Device Designations for its Selective Cytopheretic Device (SCD) therapy. The designations cover the treatment of systemic inflammatory response in both adult and pediatric cardiac surgery patients to help prevent post-operative complications.
• In March 2025, Talphera, Inc. (Nasdaq: TLPH) announced an agreement with the FDA to reduce the size of its NEPHRO CRRT study from 166 to 70 patients. The company also disclosed a three-tranche private placement with institutional investors and management, aiming to raise up to $14.8 million through common stock and pre-funded warrants.
• In January 2025, Talphera, Inc. (Nasdaq: TLPH) announced that the FDA has agreed to review a Prior Approval Supplement (PAS) to reduce the patient count in its NEPHRO CRRT clinical study. The PAS review is expected within 30 days and is required before the study protocol can be formally amended.

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Continuous Renal Replacement Therapy Overview
Continuous Renal Replacement Therapy (CRRT) is a vital blood purification technique used primarily in critically ill patients with acute kidney injury (AKI), particularly those who are hemodynamically unstable. Unlike intermittent hemodialysis, CRRT operates continuously over 24 hours, allowing for gradual fluid removal, better hemodynamic stability, and more effective management of fluid overload, electrolyte imbalances, and waste products. Widely used in intensive care units (ICUs), CRRT has become an essential tool in critical care nephrology, supported by advancements in machine technology and therapy modalities such as CVVH, CVVHD, and CVVHDF.

Continuous Renal Replacement Therapy Market Insights
North America is expected to dominate the continuous renal replacement therapy market during the forecast period (2025-2032), driven by a high burden of end-stage renal disease (ESRD), rapid product innovation, and a well-established healthcare infrastructure. According to the U.S. Department of Health and Human Services (2021), ESRD remains a significant public health challenge in the region. CRRT machines offer continuous renal support, effectively managing fluid overload, waste removal, and electrolyte imbalances, which enhances outcomes and quality of life for critically ill patients.

The region's growth is further fueled by active regulatory clearances and market initiatives. For instance, in December 2023, AcelRx Pharmaceuticals highlighted anticoagulation practices during CRRT in ICU settings, emphasizing the evolving therapeutic landscape. With the Emergency Use Authorization for citrate-based anticoagulants and continuous product launches by key players, North America is set to maintain a strong position in the continuous renal replacement therapy market.

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Continuous Renal Replacement Therapy Market Dynamics
According to the International Society of Nephrology (2021), over 13 million cases of acute kidney injury (AKI) occur globally each year, with the majority-around 11.3 million-emerging in low- and middle-income countries. In such high-burden regions, CRRT plays a vital role by offering continuous and gentle renal support, particularly for critically ill patients who may not tolerate conventional dialysis. Likewise, the growing prevalence of sepsis, which affects 47 to 50 million individuals annually as per the Global Sepsis Alliance (2024), is fueling the adoption of CRRT machines to stabilize organ function and support fluid and toxin removal in intensive care settings.

The continuous renal replacement therapy market is also gaining momentum due to technological innovations and product launches. For instance, Baxter's 2021 launch of PrisMax 2 in Europe introduced enhanced CRRT capabilities alongside organ support features like extracorporeal CO2 removal. Such advancements, coupled with increasing awareness initiatives like World Sepsis Day, are further propelling market expansion across key regions.

However, despite the growing demand, challenges such as fluid imbalances, blood pressure fluctuations, and electrolyte disturbances associated with CRRT may limit its broader adoption. Nonetheless, the overall outlook for the continuous renal replacement therapy market remains strong, driven by clinical necessity and ongoing innovation.

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Coverage: Global
Study Period: 2022 to 2032
Continuous Renal Replacement Therapy Market CAGR: ~7.38%
Key Continuous Renal Replacement Therapy Companies: Baxter, Fresenius Medical Care AG, NIKKISO CO., LTD, B.Braun Melsungen AG, Asahi Kasei Corporation, Infomed SA, Medtronic, NxStage Medical, Inc., Medica S.p.A., SWS Hemodialysis Care Co., Ltd, Dialco Medical Inc, Anjue Medical Equipment, Medica S.p.A., Jiangxi Sanxin Medtec, and others.

Continuous Renal Replacement Therapy Market Segmentation
Market Segmentation By Product Type: Machines and Consumables.
Market Segmentation By Modality: Modality (Slow Continuous Ultrafiltration, Continuous Venovenous Hemofiltration, Continuous Venovenous Hemodialysis (CVVHD), and Continuous Venovenous Hemodiafiltration), Patient (Adult and Pediatric).
Market Segmentation By Patient: Adult and Pediatric.
Market Segmentation By End User: Hospitals, Dialysis Centres, and others.
Market Segmentation By Geography: North America, Europe, Asia-Pacific, and Rest of the World.

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Table of Contents
1. Continuous Renal Replacement Therapy Market Report Introduction
2. Continuous Renal Replacement Therapy Market Executive Summary
3. Competitive Landscape
4. Regulatory Analysis
5. Continuous Renal Replacement Therapy Market Key Factors Analysis
6. Continuous Renal Replacement Therapy Market Porter's Five Forces Analysis
7. Continuous Renal Replacement Therapy Market Layout
8. Continuous Renal Replacement Therapy Market Company and Product Profiles
9. KOL Views
10. Project Approach
11. About DelveInsight
12. Disclaimer & Contact Us

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