Bag3-related Gene Therapies Market to Reach New Heights in Growth by 2032, DelveInsight Predicts | Rocket Pharmaceuticals, Solid Biosciences

DelveInsight's "Bag3-related Gene Therapies Market Insights, Epidemiology, and Market Forecast-2032′′ report offers an in-depth understanding of the Bag3-related Gene Therapies, historical and forecasted epidemiology as well as the Bag3-related Gene Therapies market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

The latest healthcare forecast report provides an in-depth analysis of Bag3-related Gene Therapies, offering comprehensive insights into the Bag3-related Gene Therapies revenue trends, prevalence, and treatment landscape. The report delves into key Bag3-related Gene Therapies statistics, highlighting the current and projected market size, while examining the efficacy and development of emerging Bag3-related Gene Therapies therapies. Additionally, we cover the landscape of Bag3-related Gene Therapies clinical trials, providing an overview of ongoing and upcoming studies that are poised to shape the future of Bag3-related Gene Therapies treatment. This report is an essential resource for understanding the market dynamics and the evolving therapeutic options within the Bag3-related Gene Therapies space.

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Some of the key facts of the Bag3-related Gene Therapies Market Report:
• The Bag3-related Gene Therapies market size is anticipated to grow with a significant CAGR during the study period (2019-2032)
• In April 2025, Affinia Therapeutics, a pioneering gene therapy company developing first- or best-in-class adeno-associated virus (AAV) therapies for severe cardiovascular and neurological disorders, announced that new preclinical findings on AFTX-201 (its lead program for BAG3 dilated cardiomyopathy), along with data on its novel AAV capsids targeting central nervous system (CNS) diseases and its high-yield manufacturing process, will be showcased in multiple oral and poster presentations at the 28th Annual American Society of Gene and Cell Therapy (ASGCT) 2025 Annual Meeting.
• In January 2025, Affinia Therapeutics, a cutting-edge gene therapy company focused on adeno-associated virus (AAV) therapies for severe cardiovascular and neurological diseases, has announced AFTX-201 as its lead development candidate for treating BAG3 dilated cardiomyopathy (DCM). Designed as a potential best-in-class gene therapy delivered through a single intravenous (IV) injection, AFTX-201 is currently in IND-enabling studies. Affinia successfully completed a pre-IND meeting with the U.S. FDA in late 2024 and plans to submit an IND application in the fourth quarter of 2025.
• In January 2024, Solid Biosciences is preparing to conduct biodistribution and preclinical studies of AVB-401 for BAG3 in mice and non-human primates.
• Key Bag3-related Gene Therapies Companies: Rocket Pharmaceuticals, Solid Biosciences, and others
• Key Bag3-related Gene Therapies Therapies: AAV BAG3-DCM/ REN-001, AVB-401, and others
• The Bag3-related Gene Therapies market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Bag3-related Gene Therapies pipeline products will significantly revolutionize the Bag3-related Gene Therapies market dynamics.
• Cardiomyopathy is frequently undiagnosed, so prevalence estimates may differ. It is believed that up to 1 in 500 adults could be affected. This condition can occur in males and females of any age and ethnicity.
• As reported by Ababio et al. (2022), the prevalence of idiopathic dilated cardiomyopathy (DCM) in the United States was estimated at 59.23 cases per 100,000 individuals.
• A study by Dominguez et al. (2018) estimated that around 2-4% of dilated cardiomyopathy cases are attributed to BAG3 mutations. It is projected that there are nearly 29,000 cases in the United States and approximately 33,000 patients in Europe.

Bag3-related Gene Therapies Overview
Bag3-related gene therapies are experimental treatments targeting mutations or dysfunctions in the BAG3 gene, which plays a crucial role in cellular protein quality control and heart muscle function. These therapies aim to correct or modulate BAG3 gene expression to treat diseases such as certain cardiomyopathies (heart muscle disorders) and myopathies linked to BAG3 mutations. By restoring normal BAG3 function, these gene therapies seek to improve muscle health and prevent disease progression.

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Bag3-related Gene Therapies Epidemiology
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Bag3-related Gene Therapies Epidemiology Segmentation:
The Bag3-related Gene Therapies market report proffers epidemiological analysis for the study period 2019-2032 in the 7MM segmented into:
• Total Prevalence of Bag3-related Gene Therapies
• Prevalent Cases of Bag3-related Gene Therapies by severity
• Gender-specific Prevalence of Bag3-related Gene Therapies
• Diagnosed Cases of Episodic and Chronic Bag3-related Gene Therapies

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Bag3-related Gene Therapies Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Bag3-related Gene Therapies market or expected to get launched during the study period. The analysis covers Bag3-related Gene Therapies market uptake by drugs, patient uptake by therapies, and sales of each drug.
Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the Bag3-related Gene Therapies Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Bag3-related Gene Therapies Therapies and Key Companies
• AAV BAG3-DCM/ REN-001: Rocket Pharmaceuticals
• AVB-401: Solid Biosciences

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Bag3-related Gene Therapies Market Strengths
• Heart diseases have a high prevalent pool and are chronic in nature which might a reason why key companies are targeting BAG3 related DCM and there is a possibility that they might get a first mover advantage
• Understanding BAG3 variations could lead to tailored treatments based on genetic profiles

Bag3-related Gene Therapies Market Opportunities
• Since no therapies are approved for BAG3 related gene thrapies, there is a significant market opportunity for the companies to enter this space and get the first-mover advantage

Scope of the Bag3-related Gene Therapies Market Report
• Study Period: 2019-2032
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
• Key Bag3-related Gene Therapies Companies: Rocket Pharmaceuticals, Solid Biosciences, and others
• Key Bag3-related Gene Therapies Therapies: AAV BAG3-DCM/ REN-001, AVB-401, and others
• Bag3-related Gene Therapies Therapeutic Assessment: Bag3-related Gene Therapies current marketed and Bag3-related Gene Therapies emerging therapies
• Bag3-related Gene Therapies Market Dynamics: Bag3-related Gene Therapies market drivers and Bag3-related Gene Therapies market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Bag3-related Gene Therapies Unmet Needs, KOL's views, Analyst's views, Bag3-related Gene Therapies Market Access and Reimbursement

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Table of Contents
1. Bag3-related Gene Therapies Market Report Introduction
2. Executive Summary for Bag3-related Gene Therapies
3. SWOT analysis of Bag3-related Gene Therapies
4. Bag3-related Gene Therapies Patient Share (%) Overview at a Glance
5. Bag3-related Gene Therapies Market Overview at a Glance
6. Bag3-related Gene Therapies Disease Background and Overview
7. Bag3-related Gene Therapies Epidemiology and Patient Population
8. Country-Specific Patient Population of Bag3-related Gene Therapies
9. Bag3-related Gene Therapies Current Treatment and Medical Practices
10. Bag3-related Gene Therapies Unmet Needs
11. Bag3-related Gene Therapies Emerging Therapies
12. Bag3-related Gene Therapies Market Outlook
13. Country-Wise Bag3-related Gene Therapies Market Analysis (2019-2032)
14. Bag3-related Gene Therapies Market Access and Reimbursement of Therapies
15. Bag3-related Gene Therapies Market Drivers
16. Bag3-related Gene Therapies Market Barriers
17. Bag3-related Gene Therapies Appendix
18. Bag3-related Gene Therapies Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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