SGLT2 Inhibitors Market to Accelerate Through 2034 with Expanding Indications and Robust Competitive Landscape | DelveInsight

Sodium-glucose co-transporter 2 (SGLT2) inhibitors have redefined the treatment paradigm for type 2 diabetes and are rapidly gaining traction across cardio-renal-metabolic diseases. Initially developed for glycemic control, this novel drug class has shown remarkable benefits in reducing cardiovascular and renal risks, propelling it beyond diabetic care into broader chronic disease management.

DelveInsight's latest report, "SGLT2 Inhibitors - Market Size, Target Population, Competitive Landscape & Market Forecast - 2034," offers a deep dive into the evolving commercial potential of SGLT2 inhibitors across the US, EU4 (Germany, France, Italy, Spain), the UK, and Japan. The report outlines market sizing, forecast growth, and patient population analysis across multiple indications-type 2 diabetes, heart failure (HFrEF and HFpEF), chronic kidney disease (CKD), and emerging off-label uses.

The market is currently dominated by key players including AstraZeneca (Farxiga/Forxiga), Boehringer Ingelheim & Eli Lilly (Jardiance), and Johnson & Johnson (Invokana). The competitive landscape remains dynamic, with multiple clinical trials exploring label expansion into acute heart failure, non-diabetic kidney disease, and combination therapies with GLP-1 agonists or MRAs.

As clinical data continue to validate the cardio-renal benefits and safety of SGLT2 inhibitors, the target patient population is set to expand substantially, encompassing millions worldwide at risk of heart failure, CKD progression, and cardiovascular events. Health economics, payer incentives, and guideline endorsements are also expected to drive greater adoption and long-term market penetration.

With increasing awareness, therapeutic versatility, and growing real-world evidence, the SGLT2 inhibitors market is poised for robust double-digit growth through 2034, cementing its role as a cornerstone therapy in chronic disease management.

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Some of the key insights of the SGLT2 Inhibitors Market Report:
• The SGLT2 Inhibitors market is expected to grow significantly through the forecast period (2024-2034).
• In 2023, the estimated diagnosed prevalent cases of Chronic Kidney Disease (CKD) in the 7MM reached nearly 16 million.
• Around 6.8 million heart failure cases in the US in 2023 were in patients aged 60 years and above.
• ENTRESTO dominated the Congestive Heart Failure market for years, but new drugs like SGLT2 inhibitors (FARXIGA, JARDIANCE) and VERQUVO now threaten its position.
• JARDIANCE, an SGLT2 inhibitor by Boehringer Ingelheim and Eli Lilly, received major regulatory approvals (FDA, EMA, PMDA) between 2021-2022 for treating chronic heart failure-including HFrEF and HFpEF-and is under pivotal trials for heart failure post-myocardial infarction and chronic kidney disease.
• In June 2024, the FDA approved dapagliflozin for children and adolescents aged 10 and older with type 2 diabetes, following the T2NOW trial, where it lowered HbA1c by 0.62% at 26 weeks.
• In March 2023, Boehringer Ingelheim reported Phase II data showing BI-690517, a selective aldosterone synthase inhibitor, reduced kidney damage marker albuminuria by up to 39.5% when combined with empagliflozin in chronic kidney disease patients-results presented at ASN Kidney Week 2023.
• Emerging therapies for SGLT2 Inhibitors include dapagliflozin (FARXIGA), empagliflozin (JARDIANCE), ertugliflozin, sotagliflozin, and others.
• Key companies involved in the treatment of SGLT2 Inhibitors include Novo Nordisk, AstraZeneca, Kowa Company ltd, Janssen Research & Development LLC, Youngene Therapeutics Inc. Ltd, ProSciento Inc., Inventiva Pharma, Bayer, Mitsubishi Tanabe Pharma Corporation, GlaxoSmithKline, Eli Lilly and Company, Sanofi, Johnson & Johnson Pharmaceutical, Ionis Pharmaceuticals Inc., Merck Sharp & Dohme LLC, Astellas Pharma Inc., and others.

To know in detail about the SGLT2 Inhibitors market outlook, drug uptake, treatment scenario, and epidemiology trends, click here: https://www.delveinsight.com/report-store/sglt2-inhibitors-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

SGLT2 Inhibitors Overview
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a class of oral medications primarily used to manage type 2 diabetes mellitus by blocking glucose reabsorption in the kidneys, leading to increased glucose excretion through urine. Beyond glycemic control, these inhibitors have demonstrated significant cardiovascular and renal benefits, making them a vital treatment option for patients with heart failure and chronic kidney disease. Due to their dual impact on glucose regulation and organ protection, SGLT2 inhibitors are increasingly adopted across various patient populations.

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SGLT2 Inhibitors Epidemiology
The epidemiology section offers an overview of historical, current, and projected trends in the seven major countries (7MM) from 2020 to 2034. It helps identify the factors influencing these trends by examining various studies and perspectives from key opinion leaders. Additionally, the section provides an in-depth analysis of the diagnosed patient population and future trends.

SGLT2 Inhibitors Epidemiology Segmentation:
The SGLT2 Inhibitors market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM, segmented into:
• Total Cases of Selected Indications for SGLT2 Inhibitor
• Total Eligible Patient Pool for SGLT2 Inhibitor in Selected Indications
• Total Treated Cases in Selected Indications SGLT2
• Inhibitor in the 7MM

SGLT2 Inhibitors Drugs Uptake and Pipeline Development Activities
The Drug Uptake section provides a comprehensive analysis of the adoption trends for newly launched and upcoming SGLT2 inhibitor therapies throughout the study period. It evaluates patient adoption rates, market penetration, and the commercial performance of each drug, offering clear insights into the factors that drive or impede the acceptance of these treatments in clinical practice.

The Therapeutics Assessment highlights the SGLT2 inhibitors demonstrating the fastest market uptake. It explores the key drivers behind their rapid adoption and compares market shares to identify therapies gaining significant momentum and competitive advantage.

Furthermore, the report offers an in-depth overview of the current SGLT2 inhibitor pipeline, covering investigational drugs at various stages of development. It profiles leading pharmaceutical and biotech companies actively advancing these targeted therapies and provides the latest updates on strategic developments such as partnerships, mergers and acquisitions, and licensing agreements that are shaping the future landscape of SGLT2 inhibitors.

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SGLT2 Inhibitors Market Outlook
The SGLT2 inhibitors market is poised for significant expansion and transformation through 2034. This growth is driven by the rapidly increasing prevalence of diabetes, heart failure, and chronic kidney disease worldwide, which fuels demand for effective therapies with multifaceted benefits. Clinical trials continue to reinforce the cardiovascular and renal protective effects of SGLT2 inhibitors, solidifying their role as a cornerstone treatment beyond glucose lowering.

Innovation in drug development, including novel agents with enhanced efficacy and safety profiles, as well as fixed-dose combination therapies, is expected to accelerate market penetration. Moreover, rising awareness among healthcare professionals and patients about the broad therapeutic benefits is propelling adoption globally. Despite cost and safety challenges, the potential for improved patient outcomes and expanding approved indications presents lucrative opportunities for pharmaceutical companies. Consequently, the SGLT2 inhibitors market is set to witness robust, sustained growth, becoming an integral part of the therapeutic landscape for metabolic and cardiorenal diseases.

SGLT2 Inhibitors Market Drivers
• The growing clinical evidence supporting the use of SGLT2 inhibitors for heart failure and chronic kidney disease is broadening their therapeutic applications, thereby increasing demand.
• The global increase in diabetes and associated cardiovascular and renal complications is driving the adoption of SGLT2 inhibitors as part of standard care.

SGLT2 Inhibitors Market Barriers
• Issues such as urinary tract infections and volume depletion limit widespread use and require careful patient monitoring.
• The relatively high price of SGLT2 inhibitors, coupled with variable insurance coverage, can restrict patient access, especially in low- and middle-income regions.

Scope of the SGLT2 Inhibitors Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan].
• Key SGLT2 Inhibitors Companies: Novo Nordisk, AstraZeneca, Kowa Company, Janssen Research & Development LLC, Youngene Therapeutics Inc. Ltd, ProSciento Inc., Inventiva Pharma, Bayer, Mitsubishi Tanabe Pharma Corporation, GlaxoSmithKline, Eli Lilly and Company, Sanofi, Johnson & Johnson Pharmaceutical, Ionis Pharmaceuticals Inc., Merck Sharp & Dohme LLC, Astellas Pharma Inc., and others.
• Key SGLT2 Inhibitors Therapies: dapagliflozin (FARXIGA), empagliflozin (JARDIANCE), ertugliflozin, sotagliflozin, and others.
• SGLT2 Inhibitors Therapeutic Assessment: SGLT2 Inhibitors currently marketed, and SGLT2 Inhibitors emerging therapies.
• SGLT2 Inhibitors Market Dynamics: SGLT2 Inhibitors market drivers and SGLT2 Inhibitors market barriers.
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies.
• SGLT2 Inhibitors Unmet Needs, KOL's views, Analyst's views, SGLT2 Inhibitors Market Access and Reimbursement.

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Table of Contents
1. SGLT2 Inhibitors Market Report Introduction
2. Executive Summary for SGLT2 Inhibitors
3. SWOT analysis of SGLT2 Inhibitors
4. SGLT2 Inhibitors Patient Share (%) Overview at a Glance
5. SGLT2 Inhibitors Market Overview at a Glance
6. SGLT2 Inhibitors Disease Background and Overview
7. SGLT2 Inhibitors Epidemiology and Patient Population
8. Country-Specific Patient Population of SGLT2 Inhibitors
9. SGLT2 Inhibitors Current Treatment and Medical Practices
10. SGLT2 Inhibitors Unmet Needs
11. SGLT2 Inhibitors Emerging Therapies
12. SGLT2 Inhibitors Market Outlook
13. Country-Wise SGLT2 Inhibitors Market Analysis (2020-2034)
14. SGLT2 Inhibitors Market Access and Reimbursement of Therapies
15. SGLT2 Inhibitors Market Drivers
16. SGLT2 Inhibitors Market Barriers
17. SGLT2 Inhibitors Appendix
18. SGLT2 Inhibitors Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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