Rheumatic Heart Disease Market Projected for Steady Growth through 2034: Advancements in Prevention and Treatment | DelveInsight

Rheumatic Heart Disease (RHD) is a chronic, potentially debilitating condition caused by damage to heart valves following untreated or poorly managed rheumatic fever, itself triggered by Group A streptococcal infections. Despite being largely preventable, RHD remains a significant health burden globally, especially in low- and middle-income regions, leading to severe complications such as heart failure and premature death.

Ongoing improvements in early diagnosis, antibiotic prophylaxis, and surgical interventions are reshaping the management of RHD. Additionally, innovative therapeutic approaches and enhanced healthcare access are driving optimism for improved patient outcomes worldwide.

DelveInsight's comprehensive report, Rheumatic Heart Disease - Market Insight, Epidemiology, and Market Forecast - 2034, offers an in-depth analysis of the evolving landscape of RHD. The report details epidemiological trends, including age-specific and regional prevalence, risk factors, and disease burden, along with a thorough review of current treatment strategies and promising pipeline therapies across key markets such as the US, Europe, and Asia-Pacific.

Supported by increased research funding and healthcare initiatives, the RHD market is anticipated to witness consistent growth and expanding treatment options through 2034.

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Some of the key insights of the Rheumatic Heart Disease Market Report:
• The rheumatic heart disease market is expected to grow significantly through the forecast period (2024-2034).
• Rheumatic heart disease (RHD) is the most common acquired heart disease in people under 25 years old.
• It affects an estimated 55 million people globally.
• RHD causes approximately 360K deaths annually, mostly in low- and middle-income countries.
• The disease often begins in childhood and can result in death or lifelong disability.
• Women are more frequently affected by RHD than men.
• The highest age-specific prevalence is seen in women aged 25-29 and men aged 20-24.
• In June 2024, Foldax announced positive 30-day results from a clinical study of its TRIATM mitral surgical heart valve, utilizing the novel LifePolymerTM material. The study, conducted in India, demonstrated favorable safety and hemodynamic performance, indicating potential benefits for RHD patients requiring valve replacement.
• In June 2024, Foldax announced its intention to seek regulatory approval for the TRIA mitral surgical heart valve in India, targeting the high prevalence of RHD in the region. The company aims to leverage positive clinical outcomes from Indian studies to support future FDA approval processes.
• In Jan 2024, A novel AI platform developed by Children's National Hospital was reported to match cardiologists in detecting RHD. The technology aims to enhance early diagnosis, particularly in resource-limited settings, by analyzing echocardiographic data to identify signs of the disease.
• Emerging therapies for Rheumatic Heart Disease include Rivaroxaban, Dapagliflozin, and others.
• Key companies involved in the treatment of Rheumatic Heart Disease include Eli Lilly and Company, Bayer, Pfizer, Johnson & Johnson, Bristol-Myers Squibb, and AstraZeneca, and others.

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Rheumatic Heart Disease Overview
Rheumatic Heart Disease (RHD) is a chronic and preventable condition caused by damage to the heart valves following an episode of acute rheumatic fever (ARF), which itself is a complication of untreated or inadequately treated Group A Streptococcal throat infections. The inflammation from ARF can cause scarring and deformity of the heart valves, leading to long-term cardiovascular complications.

RHD most commonly develops in children and adolescents but often presents with serious complications in young adults. It can lead to severe outcomes such as heart failure, stroke, infective endocarditis, and complications during pregnancy. The mitral and aortic valves are most frequently affected, resulting in stenosis or regurgitation.

Globally, RHD remains a significant health burden, particularly in low- and middle-income countries where access to early diagnosis and antibiotics is limited. It is the most common acquired heart disease in people under 25 years of age, affecting around 55 million individuals worldwide and causing approximately 360,000 deaths each year. The disease has a higher prevalence among women, especially those in their reproductive years.

Effective prevention strategies, including timely treatment of streptococcal throat infections and long-term antibiotic prophylaxis for those with a history of ARF, are critical to reducing the incidence and complications of RHD. Despite its preventable nature, the persistence of RHD highlights the need for improved healthcare infrastructure, awareness, and policy support in endemic regions.

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Rheumatic Heart Disease Epidemiology
The epidemiology section offers an overview of historical, current, and projected trends in the seven major countries (7MM) from 2020 to 2034. It helps identify the factors influencing these trends by examining various studies and perspectives from key opinion leaders. Additionally, the section provides an in-depth analysis of the diagnosed patient population and future trends.

Rheumatic Heart Disease Drugs Uptake and Pipeline Development Activities
The Drug Uptake section offers a detailed analysis of the adoption trends of newly launched and upcoming therapies for Rheumatic Heart Disease throughout the study period. It evaluates patient adoption rates, market penetration, and the commercial performance of each therapy, providing a clear understanding of the factors driving or hindering the market acceptance of these treatments.

The Therapeutics Assessment further highlights the Rheumatic Heart Disease drugs demonstrating the most rapid uptake. It examines the underlying drivers contributing to their swift adoption and compares the market share of these therapies to identify those gaining significant traction.

Additionally, the report provides an in-depth overview of the current therapeutic pipeline for Rheumatic Heart Disease, covering investigational drugs at various stages of development. It profiles the key pharmaceutical and biotech companies actively involved in advancing targeted treatments and presents the latest updates on partnerships, mergers and acquisitions, licensing deals, and other strategic developments shaping the future of Rheumatic Heart Disease therapeutics.

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Rheumatic Heart Disease Market Outlook
The Rheumatic Heart Disease (RHD) market is poised for gradual growth over the forecast period, primarily driven by increased awareness, improved diagnostic capabilities, and public health initiatives focused on early detection and prevention. Advances in echocardiographic screening, especially in school-based and community-level programs, are enabling earlier intervention and better disease management. This shift toward early diagnosis is expected to reduce long-term complications and the overall healthcare burden, particularly in endemic regions.

Market dynamics are also influenced by the development of novel therapies and increased access to surgical interventions, including valve repair and replacement procedures. In addition, the rising emphasis on antibiotic prophylaxis and secondary prevention programs is reshaping treatment landscapes in low-resource settings. While high-income countries benefit from better healthcare infrastructure, efforts are being made to bridge the gap in underserved regions through international collaborations and funding support.

Despite these advances, the RHD market faces ongoing barriers such as healthcare inequity, limited access to advanced treatment in rural areas, and a lack of disease-specific therapies. Current management relies heavily on symptomatic treatment and surgical correction, underlining the need for research into targeted therapies. Nonetheless, growing investments in cardiovascular health and digital health integration offer promising avenues for improving disease outcomes and expanding the reach of care globally.

Rheumatic Heart Disease Market Drivers
• Increased global awareness campaigns and implementation of school-based screening and antibiotic prophylaxis programs, especially in endemic regions, are driving early diagnosis and management of RHD.
• Improvements in echocardiographic techniques, valve repair/replacement surgeries, and better access to cardiac care in developing regions are contributing to improved outcomes and expanding the treatment market.

Rheumatic Heart Disease Market Barriers
• Inadequate healthcare infrastructure, limited access to diagnostics and surgery, and high out-of-pocket costs continue to restrict care delivery in many low- and middle-income countries.
• The absence of disease-specific pharmacological treatments results in reliance on antibiotics and symptomatic care, limiting innovation and long-term disease control in RHD.

Scope of the Rheumatic Heart Disease Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan].
• Key Rheumatic Heart Disease Companies: Eli Lilly and Company, Bayer, Pfizer, Johnson & Johnson, Bristol-Myers Squibb, and AstraZeneca, and others.
• Key Rheumatic Heart Disease Therapies: Rivaroxaban, Dapagliflozin, and others.
• Rheumatic Heart Disease Therapeutic Assessment: Rheumatic Heart Disease currently marketed, and Rheumatic Heart Disease emerging therapies.
• Rheumatic Heart Disease Market Dynamics: Rheumatic Heart Disease market drivers and Rheumatic Heart Disease market barriers.
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies.
• Rheumatic Heart Disease Unmet Needs, KOL's views, Analyst's views, Rheumatic Heart Disease Market Access and Reimbursement.

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Table of Contents
1. Rheumatic Heart Disease Market Report Introduction
2. Executive Summary for Rheumatic Heart Disease
3. SWOT analysis of Rheumatic Heart Disease
4. Rheumatic Heart Disease Patient Share (%) Overview at a Glance
5. Rheumatic Heart Disease Market Overview at a Glance
6. Rheumatic Heart Disease Disease Background and Overview
7. Rheumatic Heart Disease Epidemiology and Patient Population
8. Country-Specific Patient Population of Rheumatic Heart Disease
9. Rheumatic Heart Disease Current Treatment and Medical Practices
10. Rheumatic Heart Disease Unmet Needs
11. Rheumatic Heart Disease Emerging Therapies
12. Rheumatic Heart Disease Market Outlook
13. Country-Wise Rheumatic Heart Disease Market Analysis (2020-2034)
14. Rheumatic Heart Disease Market Access and Reimbursement of Therapies
15. Rheumatic Heart Disease Market Drivers
16. Rheumatic Heart Disease Market Barriers
17. Rheumatic Heart Disease Appendix
18. Rheumatic Heart Disease Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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