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PARP Inhibitors Market Demand Drivers Challenges and Technological Advancements in Cancer Care
PARP Inhibitors Market
Global PARP Inhibitors Market 2025-2034 full Research Repot latest version is now available.
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Poly (ADP-ribose) polymerase (PARP) inhibitors target a family of 17 enzymes responsible for catalyzing the formation of poly (ADP-ribose) chains, which are subsequently transferred to specific proteins involved in DNA repair. These enzymes play a critical role in the repair of single-stranded DNA breaks, a process essential for maintaining genomic stability following damage caused by factors such as ultraviolet radiation, ionizing radiation, certain chemotherapeutic agents, and environmental toxins.
By inhibiting the activity of PARP enzymes, these inhibitors prevent the repair of DNA damage, leading to cell death, particularly in cancer cells deficient in alternative DNA repair pathways. The anticipated global increase in the elderly population-who are more susceptible to the development of chronic diseases-is expected to drive growing demand for PARP inhibitors. The population aged 65 and older is projected to double in the coming years, further elevating the market potential for these therapeutics.
Despite the promising outlook, market growth may be constrained by the development of resistance to PARP inhibitors and their limited efficacy in certain patient subgroups. These challenges underscore the need for continued research and development to enhance the clinical utility of PARP inhibitors in the treatment of cancer and other age-related diseases.
List of Prominent Players in the PARP Inhibitors Market:
• Johnson & Johnson Services, Inc.
• Merck KGaA
• GSK plc.
• Pfizer Inc.
• AbbVie Inc.
• Teva Pharmaceutical Industries Ltd.
• Artios Pharma
• Genentech, Inc.
• Karyopharm Therapeutics Inc.
• Repare Therapeutics Inc
• ONO PHARMACEUTICAL CO., LTD
• Jiangsu Hengrui Pharma Co., Ltd.
• Bristol-Myers Squibb Co
• AstraZeneca plc
• Checkpoint Therapeutics, Inc.
• Eisai Co., Ltd.
• IMPACT Therapeutics
• JEIL PHARMA CO., LTD.
• Kyowa Kirin Co., Ltd
• SyntheX
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Market Dynamics:
Drivers:
The primary driver of market growth is the rising global incidence of prostate cancer. According to data from the World Cancer Research Fund, prostate cancer ranks as the second most common cancer among men and the fourth most prevalent cancer overall. Furthermore, the expanding use of Olaparib as a first-line therapy for advanced prostate cancer is anticipated to significantly contribute to the growth of the PARP inhibitors market within this segment. Additionally, the increasing application of PARP inhibitors in combination with other breast cancer treatments, such as radiation and chemotherapy, to effectively address DNA damage caused by ultraviolet (UV) radiation, is expected to further propel market expansion.
Challenges:
The market faces challenges due to intense competition among pharmaceutical companies developing PARP inhibitors, which may lead to market saturation, pricing pressures, and difficulties in differentiating products. Moreover, the substantial costs associated with research, development, and clinical trials present a considerable financial risk. These high development expenditures could limit the entry of new players and influence pricing strategies, thereby impacting the overall market dynamics.
Regional Trends:
The North American market for PARP inhibitors is projected to hold a significant share of revenue and exhibit a strong compound annual growth rate (CAGR) in the coming years. A key trend in this region is the integration of genomic testing into standard oncology practices, supported by advanced healthcare infrastructure and increased awareness. This facilitates widespread genetic screening for mutations, enabling targeted treatment with PARP inhibitors. In Europe, the market is characterized by numerous collaborative efforts between academic institutions and pharmaceutical companies. These strategic partnerships and joint research initiatives aim to accelerate clinical trials, expand treatment indications, and optimize the use of PARP inhibitors across a range of cancer types.
Recent Developments:
• In 2023, an acquisition of CinCor Pharma, Inc. was announced by AstraZeneca in order to enhance its cardiorenal pipeline. CinCor's candidate medication, baxdrostat (CIN-107), an aldosterone synthase inhibitor (ASI), is being integrated into this strategic approach to address resistant to treatment hypertension by reducing blood pressure.
• In 2022, AstraZeneca and G42 Healthcare have formed a strategic partnership to produce pharmaceutical products in Abu Dhabi. The objective of this partnership is to improve the local manufacturing capabilities and facilitate the production of essential pharmaceuticals, thereby increasing the accessibility of healthcare in the region.
• In 2022, Helio Genomics, in collaboration with Fulgent Genetics, has obtained a new Category I CPT code from the AMA for HelioLiver, thereby facilitating the widespread implementation of advanced surveillance tests for liver cancer in the United States. This accomplishment broadens the company's market presence and product line.
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Segmentation of PARP Inhibitors Market-
By Product-
• Niraparib (Zejula)
• Olaparib (Lynparza)
• Rucaparib (Rubraca)
• Talazoparib (Talzenna)
• Veliparib
• Other Pipeline Drugs
By Indication-
• Ovarian Cancer
• Breast cancer
• Prostate and Pancreatic Cancer
By Region-
North America-
• The US
• Canada
• Mexico
Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe
Asia-Pacific-
• China
• Japan
• India
• South Korea
• South East Asia
• Rest of Asia Pacific
Latin America-
• Brazil
• Argentina
• Rest of Latin America
Middle East & Africa-
• GCC Countries
• South Africa
• Rest of Middle East and Africa
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InsightAce Analytic is a market research and consulting firm that enables clients to make strategic decisions. Our qualitative and quantitative market intelligence solutions inform the need for market and competitive intelligence to expand businesses. We help clients gain competitive advantage by identifying untapped markets, exploring new and competing technologies, segmenting potential markets and repositioning products. Our expertise is in providing syndicated and custom market intelligence reports with an in-depth analysis with key market insights in a timely and cost-effective manner.
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A PARP (poly ADP-ribose polymerase) inhibitor is a substance that blocks PARP enzyme in the cell. DNA damage occurs during cancer. Blocking of PARP helps the cancer cells in repairing their damaged part of DNA.
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