Press release
Antisense Oligonucleotide Therapeutics Market Set for Exponential Growth with Breakthroughs in RNA Targeting Technologies
Antisense Oligonucleotide Therapeutics Market
Antisense oligonucleotides (ASOs) are short, single-stranded sequences of DNA or RNA designed to bind selectively to messenger RNA (mRNA) molecules within cells. By targeting mRNA prior to translation, ASOs inhibit the synthesis of disease-associated proteins without affecting proteins that have already been produced. This mechanism makes ASOs a valuable therapeutic tool in the treatment of a range of conditions, including diabetes, asthma, alopecia, inflammation, and central nervous system disorders.
In addition to their therapeutic applications, ASOs are widely used in genomic research to study gene function and regulation. Notable examples of approved antisense therapies include mipomersen, indicated for the management of high cholesterol, and fomivirsen, used in the treatment of cytomegalovirus (CMV) retinitis. The ability of ASOs to modulate gene expression at the mRNA level underscores their significance in modern medicine, particularly in the development of precision therapies targeting genetic disorders.
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The growth of the antisense oligonucleotide therapeutics market is driven by increasing consumer acceptance of antisense drugs, rising investments in research and development, the prevalence of neurological disorders, and an aging global population. Regulatory approvals from agencies such as the U.S. Food and Drug Administration (FDA) for novel antisense oligonucleotide therapies are expected to further bolster market expansion. Additionally, strategic mergers and acquisitions aimed at broadening product portfolios are anticipated to play a significant role in propelling the global antisense oligonucleotide market in the coming years.
However, the market's growth may be constrained by factors such as the high cost of antisense oligonucleotide therapies and the availability of synthetic alternatives. Moreover, evolving regulatory requirements pose additional challenges to market advancement. Despite these obstacles, continued investments by leading industry players are projected to create lucrative opportunities and drive revenue growth throughout the forecast period.
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Regionally, Europe is expected to be a key contributor to the antisense oligonucleotide therapeutics market, supported by increasing adoption of innovative antisense drugs. Prominent European companies are focusing on strategic mergers and acquisitions, alongside efforts to enhance their antisense oligonucleotide product portfolios, further strengthening the region's market position.
In addition, the North American Antisense Oligonucleotide Therapeutics market is expected to grow significantly during the forecast period. Several biotechnology firms have invested a lot of money in creating RNAi medicines. Giant pharmaceutical corporations have entered into partnerships or license agreements with several smaller businesses to benefit from the anticipated revenue growth in this market over the projection period.
Major market players operating in the Antisense Oligonucleotide Therapeutics market include Pharmaceuticals, Inc., Sarepta Therapeutics, Biogen, Alnylam Pharmaceuticals, Inc., Antisense Therapeutics Limited, Sarna Therapeutics GmbH, Arrowhead Pharmaceuticals, Inc., Atlantic Pharmaceuticals, Inc., GlaxoSmithKline plc, Gerona Corporation, Gradualist, ICO Therapeutics, Aptos Biosciences, Enzo Pharmaceuticals, Inc., Bio-Path Holdings, Inc., Gene Signal International SA, Marina Biotech, mirage Therapeutics, Inc., Synodic, Inc., Oncogene Pharmaceuticals Inc., Pharm axis Ltd, Regulus Therapeutics Inc., Reran Pharmaceuticals, Inc., and RI Pharmaceuticals, among others.
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Recent collaborations and agreements in the market:
• In January 2021, MilliporeSigma (US) acquired AmpTec, a well-known German business specializing in contract development and manufacturing mRNA (CDMO).
• In August 2019, Integrated DNA Technology released tools- oligo pools, a set of 350-nucleotide-long, high-quality DNA oligonucleotides (US).
Market Segments
Global Antisense Oligonucleotide Therapeutics Market, by Therapy, 2022-2030 (Value US$ Mn)
• Monotherapy
• Combination
Global Antisense Oligonucleotide Therapeutics Market, by Molecule Target Indication, 2022-2030 (Value US$ Mn)
• DNA Molecule
• RNA Molecule
Global Antisense Oligonucleotide Therapeutics Market, by Target Indication, 2022-2030 (Value US$ Mn)
• Duchenne Muscular Atrophy
• Spinal Muscular Atrophy
• Familial Chylomicronemia Syndrome
• Amyotrophic Lateral Sclerosis
• Familial Partial Lipodystrophy
• Hereditary Transthyretin-Mediated (hatter) Amyloidosis
• Huntington's Disease
• Others
Global Antisense Oligonucleotide Therapeutics Market, by Region, 2022-2030 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• U.S.
• Canada
Europe Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Antisense Oligonucleotide Therapeutics Market, by Country, 2022-2030 (Value US$ Mn)
• GCC Countries
• South Africa
o Rest of Middle East & Africa
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