Press release
Relapsed/Refractory Acute Myeloid Leukemia Pipeline Appears Robust With 50+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight
Discover the latest drugs and treatment options in the Relapsed/Refractory Acute Myeloid Leukemia Pipeline. Dive into DelveInsight's comprehensive report today! @ Relapsed/Refractory Acute Myeloid Leukemia Pipeline Outlook [https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr]
Key Takeaways from the Relapsed/Refractory Acute Myeloid Leukemia Pipeline Report
* In May 2025, ARCE Therapeutics Inc. announced a study is ARD103, a C-type lectin-like molecule-1 (CLL-1) autologous chimeric antigen receptor T-cells (CAR-T). CLL-1 is highly expressed on both myeloid blasts and leukemia stem cells (LSCs) but is absent on normal hematopoietic stem cells (HSCs), suggesting CLL-1 as an excellent therapeutic target for AML and hence other potential myeloid malignancies.
* In May 2025, Vor Biopharma announced a Phase 1/2 study of donor-derived anti-CD33 Chimeric Antigen Receptor (CAR) T cell therapy (VCAR33) in patients with relapsed or refractory Acute Myeloid Leukemia (AML) after human leukocyte antigen (HLA)-matched allogeneic hematopoietic cell transplant (alloHCT).
* In May 2025, Apollo Therapeutics Ltd conducted a phase 1/2 study to determine the safety, tolerability, and efficacy of APL-4098 alone and/or in combination with azacitidine for the treatment of relapsed or refractory (R/R) acute myeloid leukemia (AML), myelodysplastic syndrome (MDS)/AML and MDS-excess blasts (EB). Participants with the MDS-EB subtype will be eligible for the Phase 1 part of the study only.
* DelveInsight's Relapsed/Refractory Acute Myeloid Leukemia Pipeline report depicts a robust space with 50+ active players working to develop 75+ pipeline therapies for Relapsed/Refractory Acute Myeloid Leukemia treatment.
* The leading Relapsed/Refractory Acute Myeloid Leukemia Companies such as Ascentage Pharma, Cullinan Oncology, Kronos Bio, Maxinovel Pharmaceuticals, AB Science, CicloMed, Karyopharm Therapeutics, Antengene Corporation, GlycoMimetics, Servier, Novartis, ImmunoGen and others.
* Promising Relapsed/Refractory Acute Myeloid Leukemia Pipeline Therapies such as APG-2575, Cytarabine, Venetoclax, Tagraxofusp, Cladribine (CLAD), Venetoclax Oral Tablet, Selinexor, Idarubicin and others.
Stay ahead with the most recent pipeline outlook for Relapsed/Refractory Acute Myeloid Leukemia. Get insights into clinical trials, emerging therapies, and leading companies with DelveInsight @ Relapsed/Refractory Acute Myeloid Leukemia Treatment Drugs [https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr]
Relapsed/Refractory Acute Myeloid Leukemia Emerging Drugs Profile
* APG-2575: Ascentage Pharma
APG-2575 is a novel oral Bcl-2 selective small molecule inhibitor under development by Ascentage Pharma. It restores the programmed cell death mechanism (apoptosis) of tumor cells by selectively inhibiting Bcl-2 protein, thereby inducing tumor cell apoptosis. , to achieve the purpose of tumor treatment. APG-2575 is the first locally developed Bcl-2 selective inhibitor to enter clinical stage in China. APG-2575 has been granted orphan drug designation by the US FDA for five indications (Indications: refractory chronic lymphocytic leukemia CLL, multiple myeloma, Waldenstrom macroglobulinemia, acute myeloid leukemia, follicular lymphoma).
* CLN 049: Cullinan Oncology
CLN-049 (Florentine) is a humanized bispecific T cell engaging antibody being developed for the treatment of acute myeloid leukemia (AML). CLN-049 is designed to simultaneously bind to FLT3 on targeted leukemic cells and to CD3 on T cells, triggering the T cells to kill the selected cancer cells via their intrinsic cytolytic mechanisms. FLT3 is expressed frequently on AML cells and leukemic blasts but minimally on healthy blood cells, unlike other tumor surface antigens identified in AML, such as CD33 and CD123. CLN-049 can mediate potent and specific lysis of AML cells in vitro and promotes enhanced survival of mice bearing AML tumors. A phase I clinical trial with CLN-049 is currently ongoing for the treatment of patients with relapsed/refractory AML or MDS.
* Lanraplenib: Kronos Bio
Lanraplenib, is a next-generation SYK inhibitor that has previously been studied as a potential treatment for autoimmune diseases. In preclinical studies, Lanraplenib was shown to have anti-leukemic activity against NPM1-mutated and FLT3-mutated AML samples. Lanraplenib, is being developed for the treatment of patients with relapsed/refractory FLT3-mutated AML and patients newly diagnosed with NPM1-mutated and/orFLT3-mutated AML who are older than 75 years old or are not eligible for intensive induction chemotherapy.
The Relapsed/Refractory Acute Myeloid Leukemia Pipeline Report Provides Insights into
* The report provides detailed insights about companies that are developing therapies for the treatment of Relapsed/Refractory Acute Myeloid Leukemia with aggregate therapies developed by each company for the same.
* It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Relapsed/Refractory Acute Myeloid Leukemia Treatment.
* Relapsed/Refractory Acute Myeloid Leukemia Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
* Relapsed/Refractory Acute Myeloid Leukemia Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
* Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Relapsed/Refractory Acute Myeloid Leukemia market
Explore groundbreaking therapies and clinical trials in the Relapsed/Refractory Acute Myeloid Leukemia Pipeline. Access DelveInsight's detailed report now! @ New Relapsed/Refractory Acute Myeloid Leukemia Drugs [https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr]
Relapsed/Refractory Acute Myeloid Leukemia Companies
Ascentage Pharma, Cullinan Oncology, Kronos Bio, Maxinovel Pharmaceuticals, AB Science, CicloMed, Karyopharm Therapeutics, Antengene Corporation, GlycoMimetics, Servier, Novartis, ImmunoGen and others.
Relapsed/refractory acute myeloid leukemia (AML) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
* Intra-articular
* Intraocular
* Intrathecal
* Intravenous
* Ophthalmic
* Oral
* Parenteral
* Subcutaneous
* Topical
* Transdermal
Relapsed/Refractory Acute Myeloid Leukemia Products have been categorized under various Molecule types such as
* Oligonucleotide
* Peptide
* Small molecule
Unveil the future of Relapsed/Refractory Acute Myeloid Leukemia Treatment. Learn about new drugs, pipeline developments, and key companies with DelveInsight's expert analysis @ Relapsed/Refractory Acute Myeloid Leukemia Market Drivers and Barriers [https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr]
Scope of the Relapsed/Refractory Acute Myeloid Leukemia Pipeline Report
* Coverage- Global
* Relapsed/Refractory Acute Myeloid Leukemia Companies- Ascentage Pharma, Cullinan Oncology, Kronos Bio, Maxinovel Pharmaceuticals, AB Science, CicloMed, Karyopharm Therapeutics, Antengene Corporation, GlycoMimetics, Servier, Novartis, ImmunoGen and others.
* Relapsed/Refractory Acute Myeloid Leukemia Pipeline Therapies- APG-2575, Cytarabine, Venetoclax, Tagraxofusp, Cladribine (CLAD), Venetoclax Oral Tablet, Selinexor, Idarubicin and others.
* Relapsed/Refractory Acute Myeloid Leukemia Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* Relapsed/Refractory Acute Myeloid Leukemia Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
Get the latest on Relapsed/Refractory Acute Myeloid Leukemia Therapies and clinical trials. Download DelveInsight's in-depth pipeline report today! @ Relapsed/Refractory Acute Myeloid Leukemia Companies, Key Products and Unmet Needs [https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr]
Table of Contents
* Introduction
* Executive Summary
* Relapsed/refractory acute myeloid leukemia (AML): Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Relapsed/refractory acute myeloid leukemia (AML)- DelveInsight's Analytical Perspective
* Late Stage Products (Phase III)
* Drug name : Company name
* Drug profiles in the detailed report.....
* Mid Stage Products (Phase I/II)
* APG-2575: Ascentage Pharma
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I)
* CLN 049: Cullinan Oncology
* Drug profiles in the detailed report.....
* Preclinical and Discovery Stage Products
* Drug name : Company name
* Drug profiles in the detailed report.....
* Inactive Products
* Relapsed/refractory acute myeloid leukemia (AML) Key Companies
* Relapsed/refractory acute myeloid leukemia (AML) Key Products
* Relapsed/refractory acute myeloid leukemia (AML)- Unmet Needs
* Relapsed/refractory acute myeloid leukemia (AML)- Market Drivers and Barriers
* Relapsed/refractory acute myeloid leukemia (AML)- Future Perspectives and Conclusion
* Relapsed/refractory acute myeloid leukemia (AML) Analyst Views
* Relapsed/refractory acute myeloid leukemia (AML) Key Companies
* Appendix
About Us
DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.
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