Essential Tremor Pipeline: Advancing Neuromodulation and Targeted Therapies to Transform Essential Tremor Treatment | DelveInsight

The treatment landscape for Essential Tremor (ET), a prevalent neurological movement disorder characterized by involuntary rhythmic shaking, is undergoing a significant evolution. Historically managed with beta-blockers, anticonvulsants, or surgical interventions like deep brain stimulation (DBS), current research is moving toward more targeted, disease-modifying approaches. Biopharma companies are actively exploring novel mechanisms, including GABAergic modulation, T-type calcium channel blockers, and neurostimulation technologies to deliver more effective and personalized care.

DelveInsight's "Essential Tremor - Pipeline Insight, 2025" offers a comprehensive analysis of the global R&D landscape, spotlighting clinical and preclinical therapies that aim to address the root neurophysiological dysfunctions of ET. The report features promising candidates such as Ioflupane 123I, PRAX 114, and TD 567, as well as ongoing research programs targeting the thalamocortical circuitry and tremor pathophysiology.

It also examines advances in drug delivery systems, non-invasive neuromodulation devices, biomarker-guided treatment strategies, regulatory support, and strategic collaborations driving innovation. As unmet needs remain high in this underserved market, this report highlights the transformative pipeline developments shaping the future of essential tremor management.

Interested in learning more about the current treatment landscape and the key drivers shaping the essential tremor pipeline? Click here: https://www.delveinsight.com/report-store/essential-tremor-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Key Takeaways from the Essential Tremor Pipeline Report
• DelveInsight's essential tremor pipeline analysis depicts a strong space with 7+ active players working to develop 10+ pipeline drugs for essential tremor treatment.
• The leading essential tremor companies include Merz Pharma, SAGE Therapeutics, GE Healthcare, Praxis Precision Medicines, OB Pharmaceuticals, Novartis, Jazz Pharmaceuticals, and others are evaluating their lead assets to improve the essential tremor treatment landscape.
• Key essential tremor pipeline therapies in various stages of development include Botulinum toxin A, Zuranolone, Ioflupane 123I, PRAX 114, TD 567, Research programme: epilepsy and essential tremor therapeutics, SAGE 324, Rimtuzalcap, Suvecaltamide, and others.
• In February 2025, Praxis Precision Medicines shared an interim update from Study 1 of its Essential3 program evaluating ulixacaltamide for essential tremor, along with progress on other pipeline therapies and financials.
• In November 2024, Insightec received both FDA approval and CE Mark for its Exablate Prime system, now compatible with Philips MRIs, expanding access to non-invasive focused ultrasound treatment for ET and Parkinson's disease.
• In August 2024, Medtronic became the first company to gain FDA approval for performing deep brain stimulation (DBS) surgery for ET and Parkinson's disease while patients are asleep under general anesthesia.

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Essential Tremor Overview
Essential tremor is a chronic and progressive neurological disorder primarily characterized by a 4-12 Hz kinetic tremor, tremors that occur during voluntary actions such as eating or writing. While it most commonly affects the hands and arms, it can progressively extend to the head, voice, jaw, and other body parts. Due to its varied causes, clinical manifestations, treatment responses, and underlying pathology, growing evidence suggests that ET may represent a group of related disorders rather than a single condition. This has led to the emerging view that the term "essential tremors" may better capture its clinical complexity.

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Essential Tremor Treatment Analysis: Drug Profile
SAGE-324: Sage Therapeutics
SAGE-324, developed by Sage Therapeutics, is an oral investigational neuroactive steroid that acts as a positive allosteric modulator (PAM) of GABAA receptors. It targets both synaptic and extrasynaptic GABAA receptors to enhance GABAergic inhibitory signaling, crucial for regulating neuronal activity. Since GABA dysfunction is linked to the development of essential tremor (ET), SAGE-324 is being explored as a potential treatment and is currently in Phase II clinical development.

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Essential Tremor Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Intranasal
• Intrathecal
• Intravenous
• Oral
• Oral/Intravenous
• Parenteral
• Subcutaneous
• Subcutaneous/Intramuscular
• Transdermal

By Molecule Type
• Antisense oligonucleotide
• Gene therapy
• Hormones
• Neuropeptides
• Oligonucleotides
• Small Molecule
• Triglyceride

Scope of the Essential Tremor Pipeline Report
• Coverage: Global
• Key Essential Tremor Companies: Merz Pharma, SAGE Therapeutics, GE Healthcare, Praxis Precision Medicines, OB Pharmaceuticals, Novartis, Jazz Pharmaceuticals, and others.
• Key Essential Tremor Pipeline Therapies: Botulinum toxin A, Zuranolone, Ioflupane 123I, PRAX 114, TD 567, Research programme: epilepsy and essential tremor therapeutics, SAGE 324, Rimtuzalcap, Suvecaltamide, and others.

Dive deep into rich insights for drugs used for essential tremor treatment; visit @ https://www.delveinsight.com/report-store/essential-tremor-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr

Table of Contents
1. Introduction
2. Executive Summary
3. Essential Tremor Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Essential Tremor Pipeline Therapeutics
6. Essential Tremor Pipeline: Late-Stage Products (Phase III)
7. Essential Tremor Pipeline: Mid-Stage Products (Phase II)
8. Essential Tremor Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

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This release was published on openPR.