Press release
Next-Generation Complement Therapeutics Market Set for Remarkable Growth, Projected to Reach $12.9 Billion by 2034
Next Generation Complement Therapeutics Market
According to the latest research by InsightAce Analytic, the global next-generation complement therapeutics market is valued at US$ 5.0 Bn in 2024, and it is expected to reach US$ 12.9 Bn by 2034, with a CAGR of 10.0% during the forecast period of 2025-2034.
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The complement system recreates a crucial role in innate immunity and maintaining tissue homeostasis, and it protects against infection and flags apoptotic cells and debris for disposal. This complement system also contributes to the pathogenesis of inflammatory and autoimmune diseases and has driven industries and research institutes to develop novel 'next-generation' therapeutic drugs targeting different proteins and functions of the complement system.
Factors such as the high prevalence of immune system and infectious diseases, ongoing clinical trials related to complement-targeted therapeutics, growing clinical research activities for developing complement therapeutic drugs, fast adoption of next-generation technologies, availability of well-established healthcare infrastructures are projected to expand the growth of the market during the forecast years. Increasing clinical studies on complement-targeted therapeutics to treat diseases such as COVID-19, cardiac transplantation rejection, paroxysmal nocturnal hemoglobinuria and others are expected to enhance the growth opportunities in the global next-generation complement therapeutics market. On the other hand, an undiagnosed population with complement deficiency may restrain market adoption over the forecast period.
Regionally, North America is expected to lead the next-generation complement therapeutics market over the forecast period (2021-2034), owing to the fast adoption of next-generation technologies and increasing R&D investments to develop novel complement-targeted drug therapeutics. Apart from this, Europe holds the second position in this market regarding revenue share.
Key market players operating in the next-generation complement therapeutics market include Apellis Pharmaceuticals, Inc., AstraZeneca, ChemoCentryx/Amgen, Iveric Bio/Astellas Company, UCB, Regeneron, Novartis, Genentech/Roche, ImmunAbs Inc., and Other Prominent Players.
Key Developments In The Market:
• In Nov 2024, AstraZeneca achieved its goal of redefining cancer treatment by utilizing fresh data from its diversified and industry-leading hematology pipeline. Thirteen approved and possibly new medications from AstraZeneca's pipeline and portfolio in haematology will be included in 57 abstracts. These will include data from Alexion, the company's rare disease group, and key settings such as multiple myeloma (MM), chronic lymphocytic leukemia (CLL), paroxysmal nocturnal hemoglobinuria (PNH), and other hematologic diseases.
• In Nov 2023, AstraZeneca announced a collaboration and investment agreement with Cellectis, a clinical-stage biotechnology company, to accelerate the development of next-generation therapeutics in areas of high unmet need, including oncology, immunology, and rare diseases. Under the terms of the collaboration agreement, AstraZeneca will leverage Cellectis' proprietary gene editing technologies and manufacturing capabilities to design novel cell and gene therapy products.
• In Jun 2023, ImmunAbs started developing a next-generation complement 5 antibody with enhanced C5 inhibitory effectiveness and safety to treat complement-associated autoimmune diseases. The antibody treatment IM-101, the primary pipeline of ImmunAbs, targets and suppresses C5 in the complement system, a crucial gateway protein in autoimmune disorders. A different location is targeted and inhibited by IM-101 than by the currently approved medications.
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Market Dynamics:
The market for next-generation complement therapeutics has demonstrated significant growth, propelled by the approval of innovative agents that address indications with substantial unmet clinical needs. Recent studies highlight an increasingly competitive landscape wherein newer drugs offer notable advantages over established treatments. Specifically, C3 inhibitors and orally bioavailable therapies are gaining prominence. Furthermore, agents targeting niche indications and the anticipated absence of biosimilar competition for next-generation products before 2034 are key factors influencing market dynamics. On the other hand, a huge population suffering from complement deficiency remains undetected, limiting market growth during the anticipated timeframe.
Regional Analysis
Currently, North American next generation complement therapeutics is well established with portfolio of approved drugs, the US driving the regional market. The regional market is driven by its advanced healthcare system, high prevalence of target diseases (PNH, GA, gMG), and early adoption of innovative therapies, public healthcare support for rare diseases, and aging population. However, The Asia-Pacific region, specifically Japan and China, is emerging as a high-growth area, driven by recent drug approvals and enhanced healthcare accessibility. Japan's favorable policies for rare illnesses and China's healthcare reforms are facilitating the adoption of medicines for PNH and gMG, but the US and EU, despite their dominance, are experiencing slower growth due to market saturation and more stringent reimbursement standards.
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Market Segments
Global Next-Generation Complement Therapeutics Market, by Indication, 2021-2034 (Value US$ Mn)
• Paroxysmal Nocturnal Hemoglobinuria (PNH)
• Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD)
• Generalized Myasthenia Gravis (gMG)
• Atypical Hemolytic Uremic Syndrome (aHUS)
• Others
Global Next-Generation Complement Therapeutics Market, by Therapeutic Area, 2021-2034 (Value US$ Mn)
• Hematology
• Ophthalmology
• Neurology
• Immunology/Rheumatology
• Other
Global Next-Generation Complement Therapeutics Market, by Molecule Type, 2021-2034 (Value US$ Mn)
• Biologic
• Small Molecule
Global Next-Generation Complement Therapeutics Market, by Route of Administration, 2021-2034 (Value US$ Mn)
• Intravenous
• Oral
• Intravitreal
• Subcutaneous
Global Next-Generation Complement Therapeutics Market, by Complement Inhibition, 2021-2034 (Value US$ Mn)
• C5 Inhibitor
• C3 Inhibitor
• Other
Global Next-Generation Complement Therapeutics Market, by Type of Therapy, 2021-2034 (Value US$ Mn)
• Monotherapy
• Adjunctive Therapy
Global Next-Generation Complement Therapeutics Market, by Region, 2021-2034 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Next-Generation Complement Therapeutics Market, by Country, 2021-2034 (Value US$ Mn)
• U.S.
• Canada
Europe Next-Generation Complement Therapeutics Market, by Country, 2021-2034 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Next-Generation Complement Therapeutics Market, by Country, 2021-2034 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Next-Generation Complement Therapeutics Market, by Country, 2021-2034 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Next-Generation Complement Therapeutics Market, by Country, 2021-2034 (Value US$ Mn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa
Read Overview Report- https://www.insightaceanalytic.com/report/next-generation-complement-therapeutics-market/2269
About Us:
InsightAce Analytic is a market research and consulting firm that enables clients to make strategic decisions. Our qualitative and quantitative market intelligence solutions inform the need for market and competitive intelligence to expand businesses. We help clients gain a competitive advantage by identifying untapped markets, exploring new and competing technologies, segmenting potential markets, and repositioning products. Our expertise is in providing syndicated and custom market intelligence reports with an in-depth analysis with key market insights in a timely and cost-effective manner.
Contact us:
InsightAce Analytic Pvt. Ltd.
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