Global Oligonucleotide Synthesis Market Analysis 2025-2030: Growth Drivers, Challenges, And Opportunities

The Oligonucleotide Synthesis Market Report by The Business Research Company delivers a detailed market assessment, covering size projections from 2025 to 2034. This report explores crucial market trends, major drivers and market segmentation by [key segment categories].

How Big Is the Oligonucleotide Synthesis Market Size Expected to Be by 2034?
The size of the oligonucleotide synthesis market has experienced swift expansion in the recent past. Its growth is projected to continue, increasing from $10.33 billion in 2024 to $11.94 billion in 2025, which is a compound annual growth rate (CAGR) of 15.6%. Factors such as advancements in biomedical research, therapeutic development, innovative steps in biotechnology, genomic studies, and the rise of novel DNA technologies have significantly contributed to the historical growth of this market.

Anticipations are high for a swift expansion in the market size of oligonucleotide synthesis in the coming years. Market value is projected to reach $22.29 billion by 2029, aided by a compound annual growth rate (CAGR) of 16.9%. The predicted surge during this forecast period is likely due to the rise of innovative diagnostic tools, RNA interference (RNAi) treatments, regenerative medicine applications, nanotechnology utilizations, and progress in gene editing. Prevailing trends expected for this period encompass targeted drug creation, novel delivery systems, automated synthesis, application of CRISPR-cas technology, and advancements in next-generation sequencing (NGS).

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What Are the Emerging Segments Within the Oligonucleotide Synthesis Market?
The oligonucleotide synthesis market covered in this report is segmented -

1) By Type: Custom Oligos, Predesigned Oligos
2) By Product Type: Oligonucleotides, Reagents, Equipment, Services, Purification, Modification
3) By Application: Therapeutic Applications, Research Applications, Diagnostic Applications

Subsegments:
1) By Custom Oligos: Long Oligonucleotides, Short Oligonucleotides, Modified Oligonucleotides
2) By Predesigned Oligos: Gene-Specific Oligos, Probe Oligos, Primers For PCR And RT-PCR

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What Long-Term Drivers Are Shaping Oligonucleotide Synthesis Market Trends?
The escalating occurrence of chronic diseases is predicted to boost the expansion of the oligonucleotide synthesis market in the future. Chronic diseases are conditions that persist for more than a year and necessitate ongoing medical attention, potentially worsening with time. Oligonucleotides influence gene expression that leads to chronic diseases through different methods. They can target mRNA, pre-mRNA, or non-coding RNA to manipulate splicing events, trigger degradation, or hinder protein translation. For example, in September 2022, the World Health Organization, a specialized agency of the United Nations based in Switzerland, reported 41 million deaths equating to 74% of the total deaths caused by non-communicable diseases (NCDs) or chronic diseases worldwide on an annual basis. Cardiovascular diseases accounted for 17.9 million deaths, cancer 9.3 million deaths, chronic respiratory diseases 4.1 million deaths, and diabetes 2.0 million deaths. Consequently, the growing incidence of chronic and rare diseases is fueling the development of the oligonucleotide synthesis market.

Who Are the Top Competitors in Key Oligonucleotide Synthesis Market Segments?
Major companies operating in the oligonucleotide synthesis market include Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, GE HealthCare Technologies Inc., Eurofins Scientific SE, Agilent Technologies Inc., Nitto Denko Avecia Inc., Alnylam Pharmaceuticals Inc., Maravai Life Sciences, LGC Limited, Ionis Pharmaceuticals Inc., GenScript Inc., Ajinomoto Bio-Pharma Services, Sarepta Therapeutics Inc., Integrated DNA Technologies Inc., Twist Bioscience Corporation, Eurogentec SA, Kaneka Eurogentec S.A., Biocomma Limited, Bio-Synthesis Inc., TriLink BioTechnologies Incorporated, Generi Biotech s.r.o., ATDBio Ltd., BioAutomation Corporation, Biolegio B.V., Dharmacon Research Inc.

What Oligonucleotide Synthesis Market Trends Are Gaining Traction Across Different Segments?
The increase of product innovation is a primary trend being observed in the oligonucleotide synthesis market. In order to maintain their market share, major companies are focusing on creating revolutionary products. For example, Ansa Biotechnologies, Inc., based in the US and specializing in the production of intricate DNA, introduced two new products in July 2024 - Ansa Clonal DNA and Ansa DNA Fragments. Ansa Clonal DNA offers clonal, faultless DNA up to 600 base pairs long, eradicating the necessity for assembly and ensuring unprecedented exactness for intricate synthetic biology endeavors. This product guarantees flawless, ready-to-use DNA sequences making it a trusted option for the research community. Ansa DNA Fragments provides sequence-validated linear double-stranded DNA sections, also up to 600 base pairs, designed to suit a variety of research needs. Thanks to its innovative enzymatic synthesis method, Ansa consistently creates intricate DNA constructs, including repeats and secondary structures, in a highly precise manner.

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Which Regions Are Becoming Hubs for Oligonucleotide Synthesis Market Innovation?
North America was the largest region in the oligonucleotide synthesis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the oligonucleotide synthesis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

Frequently Asked Questions:
1. What Is the Market Size and Growth Rate of the Oligonucleotide Synthesis Market?
2. What is the CAGR expected in the Oligonucleotide Synthesis Market?
3. What Are the Key Innovations Transforming the Oligonucleotide Synthesis Industry?
4. Which Region Is Leading the Oligonucleotide Synthesis Market?

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