Anthrax Pipeline: 10+ Companies Advancing Cutting-Edge Vaccines and Therapeutics for Biodefense Preparedness | DelveInsight

The anthrax treatment market is evolving, with focused R&D efforts aimed at biodefense and preparedness for high-threat pathogens. Key players, including GC Pharma, Emergent BioSolutions, Blue Willow Biologics, Paratek Pharmaceuticals, Altimmune, and Greffex, are advancing next-generation antitoxins, immunotherapies, and vaccines. The current pipeline includes novel monoclonal antibodies, recombinant protective antigen vaccines, and adjunctive therapies to enhance post-exposure prophylaxis and treatment. The anthrax pipeline reflects a strong commitment to fortifying national health security while addressing gaps in rapid diagnosis and post-infection interventions.

DelveInsight's "Anthrax Pipeline Insight, 2025" comprehensively analyzes the current clinical landscape and growth prospects in the anthrax market. The report covers disease insights, treatment guidelines, and a detailed pipeline assessment from preclinical to marketed stages. It includes drug mechanisms, clinical studies, regulatory progress, and key developments such as collaborations, mergers, funding, and designations.

For emerging anthrax drugs, the anthrax pipeline analysis report provides a 360° view of the therapeutic landscape by development stage, product type, route of administration, molecule type, and mechanism of action (MOA). The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

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Key Takeaways from the Anthrax Pipeline Report
• DelveInsight's anthrax pipeline analysis depicts a strong space with 10+ active players working to develop 10+ pipeline drugs for anthrax treatment.
• The leading anthrax companies include GC Pharma, Emergent BioSolutions, BlueWillow Biologics, Paratek Pharmaceuticals, Altimmune, Greffex, Planet Biotechnology, Integrated BioTherapeutics, DEINOVE, Hawaii Biotech, VLP Biotech, Aphios Corporation, Enesi, and others are evaluating their lead assets to improve the anthrax treatment landscape.
• Key anthrax pipeline therapies in various stages of development include GC1109, AV7909, BW 1010, Omadacycline, rPA 102, NasoShield, Research programme: DNA vaccines, PBI 220, Ba ISTAb, DNV3837, and others.
• In April 2025, Elusys Therapeutics praised the introduction of H.R. 2707 - the Protecting American Families and Servicemembers from Anthrax Act - and called for its swift approval to strengthen national biodefense efforts.
• In July 2023, Emergent BioSolutions received FDA approval for CYFENDUSTM (formerly AV7909), an adjuvanted anthrax vaccine for post-exposure prophylaxis in adults aged 18-65, used alongside antibiotics. Approval was based on efficacy data from animal studies.

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Anthrax Overview
Anthrax is a rare but serious infectious disease caused by Bacillus anthracis, a gram-positive, spore-forming bacterium found naturally in soil. It primarily affects domestic and wild animals, but humans can become infected through direct or indirect contact with contaminated animals or animal products. While uncommon in regions like the United States, anthrax poses a significant public health threat due to its potential for severe illness and use as a biological weapon. The disease manifests in various forms-including cutaneous, inhalation, gastrointestinal, and injection anthrax-each with varying degrees of severity and risk.

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Anthrax Treatment Analysis: Drug Profile
GC1109: GC Pharma
GC1109 is a vaccine targeting the anthrax toxin, which acts as a receptor-binding antigen during infection. It is produced by culturing and purifying genetically engineered Bacillus brevis. In Phase I and II clinical trials, GC1109 demonstrated a strong safety profile and dose-dependent immunogenicity. The vaccine is currently in Phase II development.

AV7909: Emergent BioSolutions
AV7909 is being developed as a post-exposure prophylactic vaccine for Bacillus anthracis infection, to be used alongside standard antimicrobial therapy. It consists of Anthrax Vaccine Adsorbed (AVA) combined with an adjuvant to enhance immune response. The vaccine is currently in Phase III of clinical development.

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Anthrax Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Oral
• Parenteral
• Intravitreal
• Subretinal
• Topical

By Molecule Type
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy

Scope of the Anthrax Pipeline Report
• Coverage: Global
• Key Anthrax Companies: GC Pharma, Emergent BioSolutions, BlueWillow Biologics, Paratek Pharmaceuticals, Altimmune, Greffex, Planet Biotechnology, Integrated BioTherapeutics, DEINOVE, Hawaii Biotech, VLP Biotech, Aphios Corporation, Enesi, and others.
• Key Anthrax Pipeline Therapies: GC1109, AV7909, BW 1010, Omadacycline, rPA 102, NasoShield, Research programme: DNA vaccines, PBI 220, Ba ISTAb, DNV3837, and others.

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Table of Contents
1. Introduction
2. Executive Summary
3. Anthrax Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Anthrax Pipeline Therapeutics
6. Anthrax Pipeline: Late-Stage Products (Phase III)
7. Anthrax Pipeline: Mid-Stage Products (Phase II)
8. Anthrax Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

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Jatin Vimal
jvimal@delveinsight.com
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Healthcare Consulting
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About DelveInsight
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This release was published on openPR.