Lewy Body Disease Pipeline: 10+ Innovators Advancing Disease-Modifying and Symptomatic Therapies | DelveInsight

Lewy Body Disease (LBD), including dementia with Lewy bodies and Parkinson's disease dementia, is a complex neurodegenerative condition attracting the attention of over 10 key companies such as Cognition Therapeutics, Eli Lilly and Company, Athira Pharma, and NLS Pharmaceutics. The LBD pipeline features therapies targeting alpha-synuclein, neuroprotective agents, and symptomatic treatments that address cognition, motor symptoms, and neuropsychiatric complications. With no approved disease-modifying treatment, this pipeline represents a vital frontier in neurodegenerative drug development, aiming to slow progression and enhance patient outcomes.

DelveInsight's "Lewy Body Disease Pipeline Insight, 2025" comprehensively analyzes the current clinical landscape and growth prospects in the Lewy body disease market. The report covers disease insights, treatment guidelines, and a detailed pipeline assessment from preclinical to marketed stages. It includes drug mechanisms, clinical studies, regulatory progress, and key developments such as collaborations, mergers, funding, and designations.

For emerging Lewy body disease drugs, the Lewy body disease pipeline analysis report provides a 360° view of the therapeutic landscape by development stage, product type, route of administration, molecule type, and mechanism of action (MOA). The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

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Key Takeaways from the Lewy Body Disease Pipeline Report
• DelveInsight's Lewy body disease pipeline analysis depicts a strong space with 10+ active players working to develop 12+ pipeline drugs for Lewy body disease treatment.
• The leading Lewy body disease companies include Annovis Bio, CervoMed, Inc, Vaxxinity, Eisai Inc., Cognition Therapeutics, Eli Lilly and Company, Athira Pharma, NLS Pharmaceutics, and others are evaluating their lead assets to improve the Lewy body disease treatment landscape.
• Key Lewy body disease pipeline therapies in various stages of development include Buntanetap, Neflamapimod, UB 312, E2027, CT1812, LY3154207, ATH-1017, Oxafuramine, and others.
• In March 2025, CervoMed Inc. announced positive results from the first 16 weeks of the Phase 2b RewinD-LB study extension, evaluating neflamapimod for treating dementia with Lewy bodies (DLB).
• In January 2025, Cognition Therapeutics announced Dr. James E. Galvin presented topline results from the SHIMMER study of zervimesine (CT1812) in dementia with Lewy bodies at the International Lewy Body Dementia Conference in Amsterdam. Dr. Galvin, study director and principal investigator, led the research funded by the National Institute on Aging.

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Lewy Body Disease Overview
Lewy Body Disease, also known as Diffuse Lewy Body Disease or Lewy Body Dementia, is a progressive neurological disorder caused by the degeneration and death of brain nerve cells, marked by the presence of abnormal protein deposits called Lewy bodies. These spherical structures disrupt normal brain function and are only identifiable post-mortem through brain tissue examination. The exact cause and risk factors remain unknown, and there is no evidence it is hereditary. The disease presents with a gradual decline in cognitive abilities, movement difficulties, autonomic dysfunction, fluctuating attention, vivid hallucinations, depression, and sleep disturbances.

Diagnosis is based on clinical symptoms, ruling out other types of dementia, and may include neurological exams, brain imaging, blood tests, sleep studies, and heart tests. There is currently no cure, but symptoms can be managed through medications like cholinesterase inhibitors for cognitive issues, Parkinson's drugs for motor symptoms, and lifestyle adaptations. However, treatment is complex, as some medications for one set of symptoms may worsen others. Supportive strategies such as simplifying tasks, maintaining structured routines, reducing environmental stressors, and carefully monitoring responses to medications are essential for improving quality of life.

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Lewy Body Disease Treatment Analysis: Drug Profile
Buntanetap: Annovis Bio
Buntanetap (formerly ANVS401 or Posiphen) is a translational inhibitor of neurotoxic aggregating proteins (TINAPs). This orally available small molecule targets multiple neurotoxic proteins simultaneously, offering a transformative approach to treating neurodegenerative diseases. As research indicates that various neurotoxic proteins contribute to these conditions, Buntanetap's ability to address them collectively makes it a promising candidate for treating Alzheimer's, Parkinson's, and other neurodegenerative disorders, including Alzheimer's in Down syndrome. The drug is currently in Phase II development for Lewy body disease.

Neflamapimod: CervoMed, Inc
Neflamapimod is an investigational oral small molecule designed to penetrate the brain and inhibit the enzyme p38 MAP kinase alpha (p38α). This enzyme, which is activated in neurons during stress and disease, plays a significant role in inflammation-induced synaptic toxicity, impairing synaptic function. By targeting p38α, Neflamapimod aims to mitigate the inflammation and synaptic dysfunction driving neurological disease progression. The drug is currently in Phase II development for Lewy body disease.

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Lewy Body Disease Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

By Molecule Type
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Scope of the Lewy Body Disease Pipeline Report
• Coverage: Global
• Key Lewy Body Disease Companies: Annovis Bio, CervoMed, Inc, Vaxxinity, Eisai Inc., Cognition Therapeutics, Eli Lilly and Company, Athira Pharma, NLS Pharmaceutics, and others.
• Key Lewy Body Disease Pipeline Therapies: Buntanetap, Neflamapimod, UB 312, E2027, CT1812, LY3154207, ATH-1017, Oxafuramine, and others.

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Table of Contents
1. Introduction
2. Executive Summary
3. Lewy Body Disease Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Lewy Body Disease Pipeline Therapeutics
6. Lewy Body Disease Pipeline: Late-Stage Products (Phase III)
7. Lewy Body Disease Pipeline: Mid-Stage Products (Phase II)
8. Lewy Body Disease Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

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This release was published on openPR.