Retinitis Pigmentosa Market Poised for Transformative Expansion by 2034 - DelveInsight | Key Players: Johnson & Johnson Innovative Medicine, MeiraGTx, Beacon Therapeutics, Nanoscope Therapeutics, Gensight Biologics

Retinitis Pigmentosa, a group of inherited retinal disorders, continues to impose a significant burden on patients and healthcare systems worldwide. Driven by an increasing prevalence and advancements in genetic research, the RP market is witnessing a paradigm shift from conventional therapies to next-generation gene therapies, retinal implants, and optogenetic approaches. With ongoing developments in retinitis pigmentosa gene therapy FDA approval, innovative treatments are emerging to address this debilitating condition.

DelveInsight's comprehensive report, "Retinitis Pigmentosa - Market Insight, Epidemiology, and Market Forecast - 2034," delivers a strategic analysis of the current and future RP market landscape. Covering major markets across the 7MM (the US, EU4, the UK, and Japan), the report delves into epidemiological segmentation, treatment trends, and pipeline innovations. With growing research into gene therapies, retinal implants, and optogenetic advancements, the RP space is poised for continued clinical and commercial expansion through 2034.

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Some of the key insights of the Retinitis Pigmentosa Market Report:
• In 2023, the retinitis pigmentosa treatment market across the 7MM was valued at approximately USD 500 million, with projections indicating substantial growth throughout the 2024-2034 forecast period.
• In 2023, the total retinitis pigmentosa prevalence across the 7MM was ~274K cases, with expected growth in the forecast period.
• The US accounted for ~113K cases, with nonsyndromic RP comprising 65% of total cases.
• X-linked RP had a prevalence of ~16K cases in the US.
• In January 2025, Beacon Therapeutics announced that the FDA granted Regenerative Medicine Advanced Therapy (RMAT) designation to laru-zova (laruparetigene zovaparvovec) for treating X-linked retinitis pigmentosa (XLRP), advancing its mission to restore vision for patients with blinding retinal diseases.
• In January 2025, PYC Therapeutics announced that its VP-001 drug program received Rare Pediatric Disease designation from the FDA, targeting PRPF31-associated vision loss. This designation supports the development of treatments for rare pediatric conditions, boosting PYC's market position and offering hope for patients with Retinitis Pigmentosa type 11.
• In January 2025, ViGeneron GmbH announced two milestones for VG901, its gene therapy for CNGA1-related retinitis pigmentosa. The FDA granted Rare Pediatric Disease Designation, and the Data Safety Monitoring Board approved dose escalation in the Phase 1b trial.
• Emerging therapies for retinitis pigmentosa include Botaretigene sparoparvovec, AGTC-501, MCO-010, GS030, 4D 125, CTx PDE6B, CTx PDE6B, OCU 400, BS01, jCell, EA-2353, Ultevursen, ADX 2191, and others.
• Key companies involved in the treatment of retinitis pigmentosa include Johnson & Johnson Innovative Medicine, MeiraGTx, Beacon Therapeutics, Nanoscope Therapeutics, Gensight Biologics, 4D Molecular Therapeutics, Coave Therapeutics, Ocugen, Bionic Sight, jCyte, Endogena Therapeutics, ProQR Therapeutics, Aldeyra Therapeutics, and others.

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Retinitis Pigmentosa Overview
Retinitis Pigmentosa is a group of inherited retinal disorders that lead to progressive retinal degeneration and vision loss. It primarily affects the rod and cone photoreceptors, causing night blindness, followed by a gradual loss of peripheral vision and later central vision decline due to cone dysfunction. Linked to genetic mutations, RP has over 44 identified genes contributing to its development.

RP can be inherited in recessive, dominant, or X-linked patterns, with nearly 50% of cases lacking a known genetic mutation. Clinically, it is categorized into syndromic, non-syndromic, and systemic RP, while its onset is classified as early-onset or late-onset RP. Common clinical signs include fundus abnormalities, vitreous deposits, white retinal dots, exudative vasculopathy resembling Coats-like disease, and sector RP.

Diagnosis is typically suspected in individuals with night vision impairment or family history of RP. It is confirmed through dark adaptation tests, electroretinograms (ERG), progressive photoreceptor dysfunction, bilateral involvement, and visual field loss, with visual acuity generally remaining intact until late-stage disease.

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Retinitis Pigmentosa Epidemiology
The epidemiology section offers an overview of historical, current, and projected trends in the seven major countries (7MM) from 2020 to 2034. It helps identify the factors influencing these trends by examining various studies and perspectives from key opinion leaders. Additionally, the section provides an in-depth analysis of the diagnosed patient population and future trends.
Retinitis Pigmentosa Epidemiology Segmentation:

The retinitis pigmentosa market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM, segmented into:
• Total Prevalent Cases of Retinitis Pigmentosa in the US
• Gender-specific Cases of Retinitis Pigmentosa in the US
• Type-specific Cases of Retinitis Pigmentosa in the US
• Sub-type Specific Cases of Syndromic and Systemic Retinitis Pigmentosa in the US
• Sub-type Specific Cases of Non-syndromic Retinitis Pigmentosa in the US

Retinitis Pigmentosa Drugs Uptake and Pipeline Development Activities
The drug uptake section examines the adoption rates of newly launched and upcoming retinitis pigmentosa drugs over the study period. It analyzes the uptake of these treatments, evaluating how patients adopt these therapies and the sales performance of each drug. This section provides a comprehensive overview of the factors that influence the acceptance and success of retinitis pigmentosa treatments on the market.

In addition, the therapeutics assessment section highlights the retinitis pigmentosa drugs that have experienced the fastest uptake. It delves into the key drivers behind their widespread use and provides a comparison of market share among these drugs. This section helps identify which therapies are gaining traction and the reasons behind their rapid adoption.

The report further explores the pipeline for retinitis pigmentosa, providing insights into therapeutic candidates at various stages of development. It identifies the key companies involved in developing targeted treatments for Retinitis Pigmentosa. The report also covers recent developments in the field, including collaborations, mergers, acquisitions, licensing agreements, and other significant updates on emerging therapies for Retinitis Pigmentosa.

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Retinitis Pigmentosa Market Outlook
The retinitis pigmentosa treatment market in the US was valued at approximately USD 260 million in 2023, with significant growth anticipated in the coming years. This expansion is expected to be driven by the launch of novel therapies, particularly gene therapies targeting specific mutations. Currently, LUXTURNA remains the only FDA-approved gene therapy, specifically addressing patients with the RPE65 mutation. However, multiple companies, including Beacon Therapeutics, MeiraGTx, and 4D Molecular Therapeutics, are actively developing new treatments that could expand therapeutic options for RP patients. With a growing focus on targetable genetic mutations, ophthalmologists and patients may soon have a wider range of advanced treatment options.

Beyond mutation-specific gene therapies, the supportive care segment presents an emerging market opportunity for patients who lack mutation-specific treatments. Since there is currently no standard therapy for RP patients without the RPE65 mutation, many rely on best supportive care methods, including vitamin supplements, sunlight protection, and visual aids. With increasing awareness and innovation, supportive treatments may evolve to enhance quality of life and slow disease progression, further expanding the RP market. As more clinical trials and research unfold, the landscape of Retinitis Pigmentosa treatments is poised for transformative advancements in the coming years.

Retinitis Pigmentosa Market Drivers
• Innovations like LUXTURNA expand treatment options, driving market growth.
• Improved screening leads to better clinical outcomes and a larger patient pool.

Retinitis Pigmentosa Market Barriers
• Expensive gene therapies restrict affordability and insurance coverage.
• Most RP patients rely on supportive care, as mutation-specific therapies remain scarce.

Scope of the Retinitis Pigmentosa Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
• Key Retinitis Pigmentosa Companies: Johnson & Johnson Innovative Medicine, MeiraGTx, Beacon Therapeutics, Nanoscope Therapeutics, Gensight Biologics, 4D Molecular Therapeutics, Coave Therapeutics, Ocugen, Bionic Sight, jCyte, Endogena Therapeutics, ProQR Therapeutics, Aldeyra Therapeutics, and others.
• Key Retinitis Pigmentosa Therapies: Botaretigene sparoparvovec, AGTC-501, MCO-010, GS030, 4D 125, CTx PDE6B, CTx PDE6B, OCU 400, BS01, jCell, EA-2353, Ultevursen, ADX 2191, and others.
• Retinitis Pigmentosa Therapeutic Assessment: Retinitis pigmentosa currently marketed, and Retinitis Pigmentosa emerging therapies
• Retinitis Pigmentosa Market Dynamics: Retinitis pigmentosa market drivers and Retinitis pigmentosa market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Retinitis Pigmentosa Unmet Needs, KOL's views, Analyst's views, Retinitis Pigmentosa Market Access and Reimbursement

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Table of Contents
1. Retinitis Pigmentosa Market Report Introduction
2. Executive Summary for Retinitis Pigmentosa
3. SWOT analysis of Retinitis Pigmentosa
4. Retinitis Pigmentosa Patient Share (%) Overview at a Glance
5. Retinitis Pigmentosa Market Overview at a Glance
6. Retinitis Pigmentosa Disease Background and Overview
7. Retinitis Pigmentosa Epidemiology and Patient Population
8. Country-Specific Patient Population of Retinitis Pigmentosa
9. Retinitis Pigmentosa Current Treatment and Medical Practices
10. Retinitis Pigmentosa Unmet Needs
11. Retinitis Pigmentosa Emerging Therapies
12. Retinitis Pigmentosa Market Outlook
13. Country-Wise Retinitis Pigmentosa Market Analysis (2020-2034)
14. Retinitis Pigmentosa Market Access and Reimbursement of Therapies
15. Retinitis Pigmentosa Market Drivers
16. Retinitis Pigmentosa Market Barriers
17. Retinitis Pigmentosa Appendix
18. Retinitis Pigmentosa Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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