Hepatitis C Virus Infection Pipeline: 20+ Leading Companies Shaping the Future of Innovative Therapies and Drug Development | DelveInsight

The Hepatitis C Virus (HCV) infection market is experiencing robust pipeline advancements, led by companies such as Genecure Biotechnologies Preclinical, iQur, and Atea Pharmaceutical. With a diverse array of antiviral agents, combination therapies, and novel mechanisms of action in development, the focus is on achieving higher cure rates, addressing drug resistance, and simplifying treatment regimens. These innovations aim to expand pan-genotypic coverage, improve patient adherence, and reduce the global disease burden, ultimately transforming the long-term management of HCV infection and moving closer to the goal of eradicating the virus.

DelveInsight's "Hepatitis C Virus Infection Pipeline Insight, 2025" comprehensively analyzes the current clinical landscape and growth prospects in the hepatitis C virus infection market. The report covers disease insights, treatment guidelines, and a detailed pipeline assessment from preclinical to marketed stages. It includes drug mechanisms, clinical studies, regulatory progress, and key developments such as collaborations, mergers, funding, and designations.

For emerging hepatitis C virus infection drugs, the hepatitis C virus infection pipeline analysis report provides a 360° view of the therapeutic landscape by development stage, product type, route of administration, molecule type, and mechanism of action (MOA). The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

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Key Takeaways from the Hepatitis C Virus Infection Pipeline Report
• DelveInsight's hepatitis C virus infection pipeline analysis depicts a strong space with 20+ active players working to develop 20+ pipeline drugs for Hepatitis C Virus Infection treatment.
• The HCV infection treatment market is advancing with new antiviral agents, combination therapies, and novel approaches, aiming for higher cure rates, improved adherence, and global disease reduction.
• The leading hepatitis C virus infection companies include Sunshine Lake Pharma Co., Ltd., GeneCure Biotechnologies, Biotron, Cocrystal Pharma, Genecure Biotechnologies Preclinical, iQur, Atea Pharmaceutical, Dongguan HEC TaiGen Biopharmaceuticals, Nanjing Sanhome Pharmaceutical, and others are evaluating their lead assets to improve the hepatitis C virus infection treatment landscape.
• Key hepatitis C virus infection pipeline therapies in various stages of development include HEC74647PA+HEC110114, HCVax, BIT 225, CC-31244, Prophylactic HCV vaccine, iQur Research programme, Bemnifosbuvir + Ruzasvir, TG-2349, SH229, and others.
• In March 2025, following a successful End-of-Phase II meeting with the FDA in January 2025, Atea is launching its global Phase III program for hepatitis C, with patient enrollment set to begin in April 2025. In December 2024, Atea announced that its Phase 2 study of bemnifosbuvir and ruzasvir for treating hepatitis C virus (HCV) met its primary endpoints.
• In June 2024, Cepheid received FDA De Novo authorization and a CLIA Waiver for Xpert® HCV, the first U.S. molecular test to detect hepatitis C RNA from a fingerstick sample, performed on the GeneXpert Xpress System.

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Hepatitis C Virus Infection Overview
Hepatitis C is a liver infection caused by the hepatitis C virus (HCV), which spreads through contact with contaminated blood. It can range from a short-term mild illness to a chronic condition leading to serious complications like liver damage, cirrhosis, liver failure, or cancer. Transmission occurs primarily through injection drug use, unsafe medical practices, unscreened blood transfusions, and certain sexual activities involving blood exposure. The infection is categorized as acute (new) or chronic (long-term). Symptoms may include fatigue, fever, nausea, abdominal pain, jaundice, dark urine, and joint pain. Treatment includes direct-acting antivirals (DAAs), which help clear the virus and prevent liver damage.

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Hepatitis C Virus Infection Treatment Analysis: Drug Profile
TG-2349: Dongguan HEC TaiGen Biopharmaceuticals
TG-2349 (Furaprevir) from Dongguan HEC TaiGen Biopharmaceuticals is an HCV protease inhibitor designed for all-oral treatment of chronic hepatitis C. It has completed Phase III trials in combination with DAG181 and Ribavirin, tested for 12 weeks in patients with HCV Genotype I infection.

CC-31244: Cocrystal Pharma
CC-31244 from Cocrystal Pharma is a non-nucleoside polymerase inhibitor (NNI) targeting NS5B polymerase for hepatitis C treatment. It is a promising pan-genotypic inhibitor with potential for ultra-short duration all-oral therapy and is currently in Phase IIa trials.

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Hepatitis C Virus Infection Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Intravenous
• Subcutaneous
• Oral
• Intramuscular

By Molecule Type
• Monoclonal antibody
• Small molecule
• Peptide

Scope of the Hepatitis C Virus Infection Pipeline Report
• Coverage: Global
• Key Hepatitis C Virus Infection Companies: Sunshine Lake Pharma Co., Ltd., GeneCure Biotechnologies, Biotron, Cocrystal Pharma, Genecure Biotechnologies Preclinical, iQur, Atea Pharmaceutical, Dongguan HEC TaiGen Biopharmaceuticals, Nanjing Sanhome Pharmaceutical, and others.
• Key Hepatitis C Virus Infection Pipeline Therapies: HEC74647PA+HEC110114, HCVax, BIT 225, CC-31244, Prophylactic HCV vaccine, iQur Research programme, Bemnifosbuvir + Ruzasvir, TG-2349, SH229, and others.

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Table of Contents
1. Introduction
2. Executive Summary
3. Hepatitis C Virus Infection Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Hepatitis C Virus Infection Pipeline Therapeutics
6. Hepatitis C Virus Infection Pipeline: Late-Stage Products (Phase III)
7. Hepatitis C Virus Infection Pipeline: Mid-Stage Products (Phase II)
8. Hepatitis C Virus Infection Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix

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